Scientific Publications Database

Article Title: Mixed-Genotype HCV Direct Acting Antiviral Outcomes: A CANUHC Analysis
Authors: Imsirovic, Haris; Macphail, Gisela; Conway, Brian; Fraser, Chris; Borgia, Sergio; Smyth, Daniel; Wong, Alexander; Vachon, Marie-Louise; Webster, Duncan; Liu, Hongqun; Feld, Jordan; Lee, Sam; Cooper, Curtis
Journal: JOURNAL OF VIRAL HEPATITIS Volume
Date of Publication:2024
Abstract:
The prevalence of mixed hepatitis C virus (HCV) genotype infection in a representative Canadian HCV cohort is reported and virological response with direct acting antiviral (DAA) treatment was evaluated. 3272 HCV-positive participants were enrolled, of which 2945 (90.0%) initiated DAA therapy. 0.8% were identified with mixed genotype infection. Overall sustained virological response (SVR) was 99.1% and did not differ based on mixed genotype status. Any historical disadvantage to achieving cure with HCV treatment in mixed genotype infection has been overcome by current DAA regimens.