Ottawa Hematology BioBank
History
Founded in 2009, The Ottawa Hospital’s Hematology BioBank stores tissue samples from patients seen in the Division of Hematology for a variety of conditions. Samples collected include: peripheral blood (buffy coat and plasma), buccal swab and bone marrow. The samples are processed, bar code-labeled (de-identified) and stored in vapour-phase liquid nitrogen at the Biorepository, Civic Campus, of The Ottawa Hospital.
Available Samples
All BioBank samples are available for purchase with the provision of an REB approved protocol (OHSN-REB). Samples are provided with a database including demographic, clinical and treatment details. Researchers within The Ottawa hospital have the option for fresh samples to be delivered to their lab for testing. Frozen samples can be shipped across Canada.
We encourage requests for sample types and conditions not currently stored to be made with the coordinator. Prospective sample collection is available to researchers year-round.
Fees:
Please contact the coordinator at: kgodard@ohri.ca for a detailed quote.
Sample Catalogue
A summary of the inventory as of January 2024 by donor and type.
| Total Donors |
3569 |
| Acute Lymphoblastic Leukemia (ALL) |
129 |
| Acute Myeloid Leukemia (AML) |
773 |
| Chronic lymphocytic leukemia (CLL) |
485 |
| Chronic myeloid leukemia (CML) |
95 |
| Leukemia NOS |
30 |
| Hodgkin’s Lymphoma |
90 |
| Non-Hodgkins Lymphoma |
510 |
| Aplastic Anemia |
35 |
| Myelodysplastic Syndrome (MDS) |
432 |
| Myeloma/MGUS |
284 |
| Myeloproliferative disorders |
78 |
| Non-malignant |
34 |
| Healthy Samples |
55 |
| Other |
530 |
| Total Samples |
36092 |
| Buccal |
3083 |
| BMA |
5766 |
| Plasma |
8862 |
| Buffy |
7457 |
| Serum |
6204 |
| Whole |
4720 |
Current projects
- Establishing the Infrastructure for Clinical Studies in Remote Areas in Ontario. Principle Investigators: Drs. Sabloff, Stanford, Ito and Nicholls, The Ottawa Hospital Research Institute. (funding OICR)
- Dissecting the Roles of the Polycomb Protein MTF2 in Leukemogenesis. Principle Investigators: Dr. Stanford (funding CIHR)
- Application of Optical Genome Mapping for Comprehensive Discovery and Characterization of Large Genomic Variants to Improve Treatment of Acute Leukemia (CHAMO), $104,924. Co-Investigator
- Development of a Diagnostic Biomarker Assay to Guide a Precision Medicine Approach Towards Acute Myeloid Leukemia. Principle Investigators: Drs. Sabloff, Stanford, Ito Nicholls and Ramsay, The Ottawa Hospital Research Institute. (funding OICR)
- Molecular Targeting of Human Acute Myeloid Leukemia and Bone Marrow Regeneration. Principle Investigators: Dr. Bhatia (funding CIHR)
Publications
- Maganti HB, Jrade H, Cafariello C, Manias Rothberg JL, Porter CJ, Yockell-Lelièvre J et al. Targeting the MTF2-MDM2 axis sensitizes refractory acute myeloid leukemia to chemotherapy. Cancer Discov 2018; : CD-17-0841.
- Boyd AL, Reid JC, Salci KR, Aslostovar L, Benoit YD, Shapovalova Z et al. Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche. Nat Cell Biol 2017; 19: 1336–1347.
- Chandran P, Le Y, Li Y, Sabloff M, Mehic J, Rosu-Myles M et al. Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors. Leuk Res 2015; 39: 486–493.
- Le Y, Fraineau S, Chandran P, Sabloff M, Brand M, Lavoie JR et al. Adipogenic Mesenchymal Stromal Cells from Bone Marrow and Their Hematopoietic Supportive Role: Towards Understanding the Permissive Marrow Microenvironment in Acute Myeloid Leukemia. Stem Cell Rev Reports 2016; 12: 235–244.
- Chmara J, Browning JWL, Atkins H, Sabloff M, McKay BC. Rapid Decrease in KRT14 and TP53 mRNA Expression in the Buccal Mucosa of Patients Receiving Total-Body Irradiation for Allogeneic Stem Cell Transplantation. Radiat Res 2018; 189: 213–218.
