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Analysis in CMAJ counters criticisms of pivotal BART trial
October 15, 2014
In a paper published by CMAJ, Drs.
Dean Fergusson
, Brian Hutton and colleagues refute three major criticisms of the BART trial, criticisms that were used as justification to bring aprotinin back on the market with revised warnings in Canada and in Europe. Aprotinin, used to control bleeding in cardiac surgery, was withdrawn worldwide in 2007 after the early termination of the Blood Conservation Using Antifibrinolytics in a Randomized Trial (BART), which showed an increased risk of death for cardiac patients on the drug, compared with available and less costly alternatives. The results of the BART trial were published in the New England Journal of Medicine in 2008. Read the
CMAJ release
.
About the Ottawa Hospital Research Institute
The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff conducting research to improve the understanding, prevention, diagnosis and treatment of human disease.
Media contact
Paddy Moore
Communications and Public Relations
Ottawa Hospital Research Institute
613-737-8899 x73687
613-323-5680 (cell)