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Researchers use rigorous approach to establish the strength of lab data to inform stem cell clinical trial
December 7, 2016
While many exciting discoveries are made in laboratories every year, few ever become successful human treatments. This may be because often the decision to start a human trial is based on a few laboratory studies instead of considering all the available evidence. Before launching the first human trial using
stem cells to treat septic shock
, Drs.
Manoj Lalu
,
Lauralyn McIntyre
, and colleagues performed a systematic review to evaluate all existing laboratory evidence of this treatment. Their review, published in
eLife,
found 18 publications that used these stem cells to treat animal models of septic shock and confirmed a consistent reduction in deaths with the treatment. These promising results supported their decision to proceed with their world-first clinical trial. They hope their method of considering all the laboratory evidence first can help researchers launch more successful human trials in the future.
Authors:
Manoj M. Lalu, Katrina J. Sullivan, Shirley H.J. Mei, David Moher, Alexander Straus, Dean A. Fergusson, Duncan J. Stewart, Mazen Jazi, Malcolm MacLeod, Brent Winston, John Marshall, Brian Hutton, Keith R. Walley, Lauralyn McIntyre, on behalf of the Canadian Critical Care Translational Biology Group.
Funders:
This research received no external funding, but all researchers at The Ottawa Hospital are supported by The Ottawa Hospital Foundation.
The Ottawa Hospital: Inspired by research. Driven by compassion
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care. See www.ohri.ca for more information about research at The Ottawa Hospital.
University of Ottawa
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
For further information, please contact
Amelia Buchanan
Senior Communication Specialist
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73687
Cell: 613-297-8315
ambuchanan@ohri.ca