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Female reproductive disorder may be linked to problems with hormone recycling
November 16, 2017
Polycystic ovarian syndrome (PCOS) is a leading cause of female infertility, affecting more than 10 million women worldwide. It is associated with abnormal levels of hormones such as androgens. New research led by Dr.
Benjamin Tsang
shows for the first time that PCOS may be associated with problems with how cells in the ovary recycle their androgen-sensing receptors. Old receptors are regularly degraded and replaced with new ones, but in a rat model of PCOS, the androgen receptor is degraded faster than it should be. This results in low androgen receptor levels and contributes to problems with egg production. This research, published in
Scientific Reports
, opens up a new avenue of research that could lead to new approaches to treat PCOS.
Authors:
Lim JJ, Lima PDA, Salehi R, Lee DR, Tsang BK.
Funders:
All research at The Ottawa Hospital is supported by generous donors to the hospital. This study was also supported by the Canadian Institutes of Health Research, the National Research Foundation of Korea and the Lalor Foundation.
The Ottawa Hospital: Inspired by research. Driven by compassion
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care. See www.ohri.ca for more information about research at The Ottawa Hospital.
University of Ottawa: —A crossroads of cultures and ideas
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
Media Contact
Jennifer Ganton
Director, Communications and Public Relations
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73325
Cell: 613-614-5253
jganton@ohri.ca