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$1.35M grant helps researchers investigate how to get disoriented muscle stem cells back on track
June 8, 2016
Dr.
Michael Rudnicki
has received $1.35M US from the National Institutes of Health to continue his research into the biological mechanisms behind Duchenne muscular dystrophy. His research team recently made the
surprising discovery
that the lethal muscle-wasting disease directly affects muscle stem cells. Patients with this disease lack the dystrophin protein, and without this protein muscle stem cells are unable to orient themselves relative to the muscle fibre. This means they cannot divide properly and generate enough precursor cells to properly repair the damaged muscle. The new grant will help the team delve into the molecular mechanisms behind this phenomenon. They will also investigate ways to restore proper cell division in these stem cells, which could potentially lead to new therapies. The disease affects approximately one in 3,600 boys, and leads to death by the second or third decade of life.
The Ottawa Hospital: Inspired by research. Driven by compassion
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care.
University of Ottawa
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
For further information, please contact
Amelia Buchanan
Senior Communication Specialist
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73687
Cell: 613-297-8315
ambuchanan@ohri.ca