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Researchers find compound that can protect mice from Ebola
July 27, 2016
Drs.
Michel Chrétien
(OHRI Emeritus Scientist),
Majambu Mbikay
and colleagues from the National Microbiology Laboratory in Winnipeg have found a compound that can protect mice from the Ebola virus, even when given as little as 30 minutes before infection. While the 2014-2015 West African epidemic that killed over 11,000 people is now under control, smaller Ebola outbreaks are frequent and continue to happen. In addition, the vaccines currently undergoing clinical trials are designed to fight the virus behind the West African outbreak, but are not being tested against the three other Ebola species that can cause disease in humans. Drs. Chrétien, Mbikay and colleagues found a compound called quercetin-3 β-O-D-glucoside that targets the early stages of infection, and was effective against two different Ebola virus species. This proof-of-concept study, published in
Antimicrobial Agents and Chemotherapy
, could potentially lead to a flexible preventative treatment against Ebola.
Authors:
Xiangguo Qiu, Andrea Kroeker, Shihua He, Robert Kozak, Jonathan Audet, Majambu Mbikay, Michel Chrétien
Funders:
Fondation Mérieux, France
The Ottawa Hospital: Inspired by research. Driven by compassion
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care.
University of Ottawa
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
For further information, please contact
Amelia Buchanan
Senior Communication Specialist
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73687
Cell: 613-297-8315
ambuchanan@ohri.ca
Tags:
Ebola
,
Infectious disease