David Grimes
Associate Scientist, Neuroscience
Ottawa Hospital Research Institute
Division Head, Neurology/Medicine
University of Ottawa
Associate Professor, Neurology/Medicine
University of Ottawa
Director, Parkinson's Disease and Movement Disorders Clinic
Ottawa Hospital
Co-Director, Parkinson Research Consortium
University of Ottawa
Research Interests
Clinical research in movement disorders with a focus on Parkinson's disease. Studies include both industry and investigator driven research exploring a wide variety of issues including clinical care models, biomarkers, observational studies, and the latest pharmacologic treatment options. Sponsors include CIHR, University of Ottawa Brain and Mind Research Institute, Michel J Fox Foundation, Parkinson Research Consortium, and Ontario Brain Institute.
Brief Biography
Dr. Grimes received his Doctorate in Medicine and completed his residency in Neurology at the University of Ottawa. He spent two years at the Toronto Hospital and the Centre for Research in Neurodegenerative Diseases as a research fellow in movement disorders and molecular genetics. He joined the Department of Medicine in Ottawa in 1999 and is the current Chair and Chief of the Division of Neurology, University of Ottawa. His major clinical interests are in the diagnosis and treatment of a wide variety of movement disorders with an emphasis on Parkinson's disease and dystonia. He has extensive experience with botulinum toxin injections for the treatment of focal dystonia and hemifacial spasm.
He received the Queen’s Diamond Jubilee
Medal (2012), nominated by the Parkinson Society Canada for leading the development
of the Canadian Guidelines on Parkinson’s disease
Selected Publications
Brodsky M, Swope D,
Grimes D. Factors that affect
the diffusion of botulinum toxins. Tremor Other Hyperkinet Mov (N Y). 2012;2.
pii: tre-02-85-417-1. Epub 2012 Aug 6 PMID:
23440162
Grimes
D, Gordon J, Snelgrove B, et al. Canadian Guidelines on Parkinson's
disease. Can J Neurol Sci. 2012;39:Suppl 4: S1-S30. PMID: 23126020
Kitada
T, Tomlinson JJ, Sio Ao H,
Grimes
DA, Schlossmacher MG. Considerations Regarding the Etiology and Future
Treatment of Autosomal Recessive Versus Idiopathic Parkinson Disease. Curr Treat
Options Neurol. 2012;14, (3):230-240, DOI: 10.1007/s11940-012-0175-8. PMID: 22547255
Tahar AH,
Chuang R, Steeves T, Jog M, Lang A,
Grimes
D. Efficacy and Safety of T2000 in
Older Patients with Essential Tremor.
Parkinsonism Relat
Disord. 2012 Dec 17. PMID: 23254160
Sinha N,
Grimes D, Rogaeva E, Tokuhiro S, Sato C, Woulfe J. Variant Alzheimer disease with spastic paraparesis and supranuclear
gaze palsy. Can J Neurol Sci. 2013
Mar;40(2):249-51. PMID:23419577
Grimes, David A. Parkinson's Disease Compendium of Therapeutic Choices for its
7th Edition (2014), Editor Barbara Jovaisas
Diseases, conditions and populations of interest
Research and clinical approaches
