Ran Klein
Clinician Investigator, Methodological & Implementation Research
Ottawa Hospital Research Institute
Imaging Physicist, Nuclear Medicine
The Ottawa Hospital
Assistant Professor, Department of Medicine
University of Ottawa
Cross appointed, Faculty of Engineering
University of Ottawa
Adjunct Professor, Department of Systems and Computer Engineering
Carleton University
Adjunct Professor, Department of Physics
Carleton University
Research Interests
Medical imaging with the a focus on:
- Image segmentation
- Automatic lesion detection
- PET lesion synthesis
- Image perception
- Quantification of physiologic function using dynamic imaging
- Motion detection and correction
- Quantitative SPECT
- Prediction of kidney failure
- Prediction of Tacrolimus dosing
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Now hiring Master's, Doctorate and Post-Doctorate trainees with experience and interest in medical imaging, machine learning, PET, software development and psychophysics. If interested please reach out by mail with a personalized statement of interest.
Specific opportunities:
- None |
Brief Biography
Ran Klein holds a PhD in Electrical Engineering and is Imaging Physicist at The Ottawa Hospital, Department of Nuclear Medicine and Molecular Imaging. He was previously a Research Associate at the University of Ottawa Heart Institute. He has nearly 20 years research experience in Nuclear Medicine that produced over 150 publications and abstracts. His greatest impact has been quantification of myocardial blood flow using rubidium-82 positron emission tomography which is applied clinically internationally. His research has resulted in software for myocardial blood flow quantification (FlowQuant, Quantify DCE) with components licensed to INVIA 4DM. Ran’s work on an automated rubidium-82 infusion system is commercialized by Jubilant-Radiopharma as Ruby-FillTM. His current interests extend beyond cardiac imaging, and include quantification of physiologic function, computer-aided diagnosis, artificial intelligence, and quality. He is an associate professor at the University of Ottawa, Department of Medicine with cross-appointment to the Faculty of Engineering, and is also an adjunct professor at Carleton University, Department of Systems and Computer Engineering and at the Department of Physics.
Selected Publications
- Ghassel S*, Jabbarpour A*, Lang J, Moulton E, Klein R, The effect of resizing on the natural appearance of scintigraphic images: an image similarity analysis, Frontiers in Nuclear Medicine, [Accepted].
- Amooei E*, Buh A, Klamrowski MM, Shorr R, McCudden CR, Green JR, Babak Rashidi B, Sood MM, Hoar S, Akbari A, Hundemer GL, Klein R, Analytical Modeling Techniques for Enhancing Tacrolimus Dosing in Solid Organ Transplantation: A Systematic Review Protocol, BMJ Open, 2024;14(1):e088775.
- Klamrowski MM*, Klein R, McCudden C, Green JR, Rashidi B, White CA, Oliver MJ, Molnar AO, Edwards C, Ramsay T, Akbari A, Hundemer GL, Derivation and Validation of a Machine Learning Model for the Prevention of Unplanned Dialysis, CJASN, 2024;19(9):1098-1108. [Online ahead of print]
- Klamrowski MM*, Klein R, McCudden C, Green JR, Ramsay T, Rashidi B, Akbari A, Hundemer GL, Short Timeframe Prediction of Kidney Failure among Patients with Advanced Chronic Kidney Disease, Clinical Chemistry, 2023;69(10):1163-73.
- Jabbarpour A*, Ghassel S*, Lang J; Leung E, Le Gal G, Klein R, Moulton, E, The past, present, and future role of artificial intelligence in ventilation/perfusion scintigraphy: A systematic review, Smin Nucl Med, 2023;53(6):752-65.
- Naik D*, Merai H, Klein R, Zeng W, Duration of Breastfeeding Interruption in Nuclear Medicine Procedures. J Nuc Med Tech, 2023;51(3):239-46.
- Klein R, Oliver M, La Russa D, Agapito J, Gaede S, Bisonnette JP, Rahmim A, Uribe C, COMP Report: CPQR technical quality control guidelines for use of Positron Emission Tomography - Computed Tomography (PET/CT) in Radiation Treatment Planning, J App Clin Med Phys, 2022;23(12):e13785.
- Su N, Wiefels C, Klein R, Zeng W, Abbaspour F, Intensity of hypermetabolic axillary lymph nodes in oncologic patients in relation to timeline following COVID-19 vaccination, J Med Img and Rad Sci. 2022;53(2):219-25.
- Naik D*, Ternan S, Degagne R; Zeng W, Klein R, Thyroid Uptake Exceeding 100%: Causes and Prevention, J Nuc Med Tech, 2022;50(2):153-60.
- Wallis J, Klein R, Bradshaw T, Catana C, Hatt M, Laforest R, Liu C, Mawlawi O, McCall K, Osborne D, Tang J, Wells RG, Ghesani M, PIDSC Remote Viewing Guidelines Document, J Nuc Med Technol, 2021;49(1):2-6.
- Klein R, deKemp RA, Selection of PET Camera and Implication on the Reliability and Accuracy of Absolute Myocardial Blood Flow Quantification, Curr Cardiol Reports, 2020;22(10):109.
- Manabe O; Yoshinaga K, Katoh C, Magota K, Klein R, deKemp RA, Naya M, Oyama-Manabe N, Tamaki N, Validation of regional myocardial blood flow quantification using 3D PET with rubidium-82 –repeatability and comparison with 2D PET data acquisition. Nuc Med Comm, 2020;41(8):768-75.
- Salman O*, Klein R, Anatomical Region Identification in Medical x-ray Computed Tomography (CT) Scans: Development and Comparison of Alternative Data-Analysis and Vision-Based Methods, Neural Computing and Applications 2020;32:17519-31.
- Klein R, Celiker-Guler E, Rotstein BH, deKemp RA, PET and SPECT Tracers for Myocardial Perfusion Imaging, Sem in Nucl Med, 2020;50(3):208-18.
- Gabrani-Juma H*, Zuckier LS, Klein R, Development and validation of the Lesion Synthesis Toolbox and the Perception Study Tool for quantifying observer limits-of-detection of lesions in positron emission tomography, J Med Imaging, 2020;7(2):022412.
- Manwell S*, Klein R, Xu To, deKemp RA, Clinical comparison of the Positron Emission Tracking (PeTrack) algorithm with the Real-Time Position Management System for respiratory gating in cardiac positron emission tomography, Med Phys, 2020;47(4):1713-26..
- Klein R, Razavi S*, Memon R*, Zuckier L, An electronic 99mTc-DTPA Glomerular Filtration Rate spreadsheet with novel embedded quality assurance features, Nuc Med Comm. 2019;40(1):30-40.
- Ocneanu A*, deKemp R, Renaud JM, Adler A, Beanlands RSB, Klein R, Optimally repeatable kinetic model variant for myocardial blood flow measurements with 82Rb PET. Computational and Mathematical Methods in Nuclear Medicine, 2017: 6810626, 11 pages.
- Klein R, Ocneanu A*, Renaud JM, Ziadi MC, Beanlands RSB, deKemp RA, Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification with 82Rb dynamic PET imaging, J Nucl Cardiol, [In press].
- Gabrani-Juma H*, Clarkin OJ, Pourmoghaddas A, Driscoll B, Wells RG, deKemp RA, Klein R, Validation of a multimodality flow phantom and its application for assessment of dynamic SPECT and PET technologies, IEEE-Trans Med Imag, 2017;36(1):132-41.
- Klein R, Hung G-U, Wu T-C, Li D, deKemp RA, Hsu B, Feasibility and Operator Variability of Myocardial Blood Flow and Reserve Measurements with 99mTc-Sestamibi Quantitative Dynamic SPECT-CT Imaging. J. Nucl. Cardiol., 2014;21(6):1075-88.
- Klein R, Beanlands RS, Wassenaar RW, Thorn S, Lamoureux M, DaSilva JN, Adler A, deKemp RA, Kinetic model based factor analysis of dynamic sequences of cardiac positron emission tomography. Med. Phys., 2010;37(8):3995-4010.
- Klein R, Adler A, Beanlands RS, deKemp RA, Precision-controlled elution of a 82Sr/82Rb generator for cardiac perfusion imaging with positron emission tomography. Phys. Med. Biol., 2007;52(3):659-673.
Diseases, conditions and populations of interest
Research and clinical approaches