What We Do
Treatment options for ovarian cancer are limited, and while tumours often respond to initial treatments, many recur and become resistant to therapy. We use experimental and computational approaches to understand why ovarian cancer treatment fails and explore new therapeutic strategies to manage the disease.
Selected Publications
- Cook, DP., Jensen, KB., Wise, K., Roach, MJ., Dezem, FS., Ryan, NK., Zamojski, M., Vlachos, IS., Knott, SRV., Butler, LM., Wrana, JL., Banovich, NE., Plummer, JT., Martelotto, LG. Benchmark analysis of imaging-based spatial transcriptomics platforms. Preprint on bioRxiv (2023). Link
- Cook, DP., Galpin, K., Rodriguez, G., Shakfa, N., Wilson-Sanchez, J., Pereira, M., Matuszewska, K., Haagsma, J., Murshed, H., Cudmore, AO., Macdonald, E., Tone, A., Shepherd, TG., Petrik, J., Koti, M., Vanderhyden, BC. Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancer. Communications Biology (2023). Link
- Cook, DP., Wrana, JL. A specialist-generalist framework for epithelial-mesenchymal plasticity in cancer. Trends in Cancer (2022). Link
- Cook, DP., Vanderhyden, BC. Transcriptional census of epithelial-mesenchymal plasticity in cancer. Science Advances (2022). Link
- Cook, DP., Vanderhyden, BC., Context specificity of the EMT transcriptional response. Nature Communications (2020). Link
Meet the Cook Lab
