Duane Hickling
Clinician Investigator, Acute Care Research
Ottawa Hospital Research Institute
Greta and John Hansen Chair in Men's Health and Basic Science Research, Division of Urology, Department of Surgery
Ottawa Hospital Research Institute
Assistant Professor, Divison of Urology, Department of Surgery
University of Ottawa
Research Interests
Research Interests:
1. Host
Defense Mechanisms in Urinary Tract Infection
The overall goal of our research is to better
understand UTI pathogenesis as it relates to the host. Specifically, we are interested in studying
constitutive and inducible expression of antimicrobial peptides/host defense
proteins in the lower urinary tract. At
the present time, our program integrates in vitro, in vivo and clinical
approaches to better understand the roles of LL-37 in UTI pathogenesis. This important work will lay the foundation
for future translational projects pertaining to the UTI and catheter biofilm
prevention.
2. Recurrent
Urinary Tract Infections
This research program is focused primarily on
uncovering those clinical factors that make some individuals prone to recurrent
UTI. By studying patient demographics
and select biomarkers we hope to gain a better understanding of susceptibility
to UTI in certain at risk populations and in those who are otherwise seemingly
healthy.
Brief Biography
Dr.
Duane Hickling has recently joined the Ottawa Hospital Research Institute as an
Associate Scientist in the Chronic Disease Program. His research focuses on
urinary tract infections and understanding how the body defends against these
at the molecular level. Dr. Hickling is also a urologist at The Ottawa Hospital
and Assistant Professor in the Division of Urology, Department of Surgery,
Faculty of Medicine at the University of Ottawa. After obtaining his MD at Western
University, he completed his residency training at The Ottawa
Hospital/University of Ottawa and then went on to do a three-year combined
clinical and research fellowship at New York University. There he trained in
female pelvic medicine and reconstructive surgery, receiving a Master’s degree
in Clinical Investigation – Translational Research.
Selected Publications
1. Predictors
of sling revision after mid-urethral sling procedures: a case-control study.
Clancy AA, Gauthier I,
Ramirez FD, Hickling D, Pascali D.
BJOG. 2018 Sep 16. doi: 10.1111/1471-0528.15470. [Epub ahead of print]
2. A
pilot randomized-controlled trial of the urodynamic efficacy of mirabegron for patients
with neurogenic lower urinary tract dysfunction.
Welk B, Hickling D, McKibbon
M, Radomski S, Ethans K.
Neurourol Urodyn. 2018 Aug 31. doi:
10.1002/nau.23774. [Epub ahead of print]
3.
Editorial
Comment.
Hickling DR.
J Urol. 2018 Oct;200(4):813-814. doi: 10.1016/j.juro.2018.03.170. Epub
2018 Jul 9. No abstract available.
4.
Do
Urodynamic Findings Other Than Outlet Obstruction Influence the Decision to
Perform a Transurethral Resection of Prostate?
Welk B, McGarry P,
Baverstock R, Carlson K, Hickling D.
Urology. 2018 Jul;117:120-125. doi:
10.1016/j.urology.2018.04.010. Epub 2018 Apr 25.
5.
Complications
after minimally invasive sacrocolpopexy with and without concomitant
incontinence surgery: A National Surgical Quality Improvement Program (NSQIP)
database study.
Clancy AA, Mallick R, Breau
RH, Khalil H, Hickling DR.
Neurourol Urodyn. 2018 Sep;37(7):2234-2241. doi:
10.1002/nau.23574. Epub 2018 Apr 10.
6.
Urinary
function following radical cystectomy and orthotopic neobladder urinary
reconstruction.
Nayak AL, Cagiannos I,
Lavallée LT, Morash C, Hickling D, Mallick R, Breau RH.
Can Urol Assoc J. 2018 Jun;12(6):181-186. doi:
10.5489/cuaj.4877. Epub 2018 Feb 23.
7. Thermal
Bladder Injury at Laparoscopic Hysterectomy.
Clancy AA, Hickling D.
J Minim Invasive Gynecol. 2018 May - Jun;25(4):562-564.
doi: 10.1016/j.jmig.2017.08.010. Epub 2017 Aug 10. No abstract available.
8. Patient-targeted
websites on overactive bladder: What are our patients reading?
Clancy AA, Hickling D,
Didomizio L, Sanaee M, Shehata F, Zee R, Khalil H.
Neurourol Urodyn. 2018 Feb;37(2):832-841. doi:
10.1002/nau.23359. Epub 2017 Aug 1.
