The Gray lab has studied the loss of protein homeostasis in aging and age-related diseases such as neurodegeneration and cancer.  Our specific focus has been on the role of deubiquitinating enzymes, their evolutionary history and functional redundancy.
Dr. Gray retired in September 2022.

Vlasschaert, C., Cook, D., Xia, X., and Gray, D.A. (2017) The Evolution and Functional Diversification of the Deubiquitinating Enzyme Superfamily.  Genome Biology and Evolution 9(3):558–573
Vlasschaert, C., Xia, X., and Gray, D.A. (2016) Selection preserves Ubiquitin Specific Protease 4 alternative exon skipping in therian mammals.  Scientific Reports 6, 20039.
Vlasschaert, C., Xia, X., Coulombe, J., and Gray, D.A. (2015) Evolution of the highly networked deubiquitinating enzymes USP4, USP15 and USP11. BMC Evolutionary Biology, 15:230
Coulombe, J., Gamage., P., Gray, M., Iqbal., M., Zhang, M., Tang., M.Y., Woulfe, J., Saffrey, J., and Gray, D.A. (2014) Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system. Frontiers in Aging Neuroscience. | doi: 10.3389/fnagi.2014.00129
Gray, D.A., and Woulfe., J. (2013) Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease. Frontiers in Genetics. 4:149. doi: 10.3389/fgene.2013.00149
Tang, M.Y., Proctor, C.J., Woulfe, J., and Gray, D.A. (2010) Experimental and Computational Analysis of Polyglutamine-Mediated Cytotoxicity. PLoS Computational Biology 6(9): e1000944.