John Woulfe
Associate Scientist, Neuroscience
Ottawa Hospital Research Institute
Attending Staff Neuropathologist, Department of Laboratory Medicine
Ottawa Hospital, Civic Campus
Assistant Professor, Department of Pathology
University of Ottawa
Research Interests
Dr. Woulfe's research interests center on the role of alpha-synuclein aggregation in the pathophysiology of Parkinson's disease. In collaboration with Dr. Doug Gray, he is creating a novel mouse model which will allow the direct visualization of alpha-synuclein aggregation in Vivo. This tool will be used to explore environmental triggers that might initiate Parkinson's disease.
Brief Biography
Dr. Woulfe is Staff Neuropathologist at the Ottawa Hospital, Associate Professor at the University of Ottawa, and Associate Scientist at the OHRI in the Center for Cancer Therapeutics.
Selected Publications
Gray M, Munoz DG, Schlossmacher M, Gray DA, Woulfe J. α-synuclein in the appendiceal mucosal plexus and macrophages of neurologically healthy subjects: implications for Parkinson’s disease initiation. Movement Disorders 2014;29(8):991-998. *Winner of Best Paper of the Year Award from Movement Disorders for 2014.
Dos Santos MP;Martin J;Woulfe J;Lim SP;Chakraborty S;, (2014 Jan), Autopsy-proven Acute Hemorrhagic Leukoencephalitis in an Elderly Patient, Can J Neurol Sci , Vol.41, Issue 1, 99-102
Shankar JJ;Woulfe J;Silva VD;Nguyen TB;, (2013 May), Evaluation of perfusion CT in grading and prognostication of high-grade gliomas at diagnosis: a pilot study, AJR Am J Roentgenol, Vol.200, Issue 5, W504-W509
McDonell LM;Mirzaa GM;Alcantara D;Schwartzentruber J;Carter MT;Lee LJ;Clericuzio CL;Graham JM;Morris-Rosendahl DJ;Polster T;Acsadi G;Townshend S;Williams S;Halbert A;Isidor B;David A;Smyser CD;Paciorkowski AR;Willing M;Woulfe J;Das S;Beaulieu CL;Marcadier, (2013 May), Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome, Nat Genet, Vol.45, Issue 5, 556-562
Sinha N;Grimes D;Tokuhiro S;Sato C;Rogaeva E;Woulfe J;, (2013 Mar), Variant Alzheimer's disease with spastic paraparesis and supranuclear gaze palsy, Can J Neurol Sci, Vol.40, Issue 2, 249-251
Milman P;Woulfe J;, (2013 Jun 8), A novel variant of neuronal intranuclear rodlet immunoreactive for 40 kDa huntingtin associated protein and ubiquitin in the mouse brain, J Comp Neurol, Vol.521, Issue 16, 3832-3846
Diseases, conditions and populations of interest
Research and clinical approaches
