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Ottawa team pioneers new approach for cancer clinical trials
September 28, 2016
What is the most efficient way to answer the most important questions to improve care for cancer patients? Drs.
John Hilton
,
Mark Clemons
and
Dean Fergusson
got a group of Ottawa researchers together to answer this question and came up eight key principles, which form the basis for their Rethinking Clinical Trials (REaCT) Program. As described in the
Journal of Oncology Practice
, REaCT involves comparing different approved treatment strategies rather than developing new ones. It also involves a streamlined process for obtaining oral (rather than written) patient consent, immediate randomization into treatment groups using a mobile device and simplified data collection. Their first trial, which compares two strategies to prevent chemotherapy-related infections in breast cancer patients, has recruited nearly 150 patients in just over 18 months, at a small fraction of the cost of most cancer clinical trials. Nine other REaCT cancer trials are currently underway (with support from the Ottawa Methods Centre) and the hope is to expand to other areas as well.
Authors:
John Hilton, Sasha Mazzarello, Dean Fergusson, Anil A. Joy, Andrew Robinson, Angel Arnaout, Brian Hutton, Lisa Vandermeer, Mark Clemons.
Funders:
The Ottawa Hospital Foundation, The Ottawa Hospital / University of Ottawa Department of Medicine and Division of Medical Oncology, Canadian Institutes of Health Research
Update:
This research was featured in the
Ottawa Citizen
story
New approach to clinical trials could revolutionize cancer care
.
The Ottawa Hospital: Inspired by research. Driven by compassion
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care. See www.ohri.ca for more information about research at The Ottawa Hospital.
University of Ottawa
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
For further information, please contact
Jennifer Ganton
Director, Communications and Public Relations
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73325
Cell: 613-614-5253
jganton@ohri.ca
Tags:
Breast cancer
,
Clinical trials
,
Pragmatic trials