Publications

Full Systematic Reviews

• A systematic review on the efficacy and safety of low molecular weight heparin as an anticancer therapeutic in preclinical animal models. PMID 32683148
• The efficacy and safety of low molecular weight heparin administration to improve survival of cancer patients: a systematic review and meta-analysis. PMID 32369854
• Neuroprotection by remote ischemic conditioning in rodent models of focal ischemia: a systematic review and meta-analysis. PMID 33405011
• The effects of resistant starches on inflammatory bowel disease in preclinical and clinical settings: a systematic review and meta-analysis. PMID 33167889
• An analysis of mesenchymal stem cell-derived extracellular vesicles for preclinical use. PMID 32697573
• From the lab to patients: a systematic review and meta-analysis of mesenchymal stem cell therapy for stroke. PMID: 31654281
• Post-operative shared-care for patients undergoing non-cardiac surgery: a systematic review and meta-analysis. PMID 31290119
• Risks and benefits of chimeric antigen receptor t-cell (CAR-T) therapy in cancer: a systematic review and meta-analysis. PMID 30948292
• Identifying stroke therapeutics from preclinical models: a protocol for a novel application of network meta-analysis. PMID 30906535
• Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review. PMID 30841915
• A systematic review of the impact of surgical special care units on patient outcomes and health care resource utilization. PMID 30676348
• Safety and efficacy of adult stem cell therapy for acute myocardial infarction and ischemic heart failure (SafeCell Heart): a systematic review and meta-analysis. PMID 30255989
• MSC-derived extracellular vesicles in preclinical animal models of bone injury: a systematic review and meta-analysis. PMID 34313927
• Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta-analysis. PMID 34596349
• A preclinical systematic review and meta-analysis assessing the effect of biological sex in lipopolysaccharide-induced acute lung injury. PMID 38349120
• Effectiveness of dexmedetomidine during surgery under general anesthesia on patient-centered outcomes: a systematic review and Bayesian meta-analysis protocol. PMID 38307526
• Safety and efficacy of adeno-associated viral gene therapy in patients with retinal degeneration: a systematic review and meta-analysis. PMID 37982768
• Recognizing patient partner contributions to health research: a systematic review of reported practices. PMID 37689741

Systematic Review Protocols

• Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol. PMID 31831057
• Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in patients with haematological and solid malignancies: protocol for a systematic review and meta-analysis. PMID 29288188
• Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol. PMID: 29116020
• Mesenchymal stromal cells as a therapeutic intervention for COVID-19: a living systematic review and meta-analysis protocol. PMID 34526123
• Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol. PMID 34127055
• Identifying effect modifiers of CAR-T cell therapeutic efficacy: a systematic review and individual patient data meta-analysis protocol. PMID 36653879

Addressing Rigour and Reproducibility in Preclinical (Lab Based) Research

• Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol. PMID 33123348
• Assessing the completeness of reporting in preclinical oncolytic virus therapy studies. PMID 31276026
• Reporting preclinical anesthesia study (REPEAT): evaluating the quality of reporting in the preclinical anesthesiology literature. PMID 31120888
• Surrogate humane endpoints in small animal models of acute lung injury: a modified Delphi consensus study of researchers and laboratory veterinarians. PMID 33332817
• Epidemiology and reporting characteristics of preclinical systematic reviews. PMID 33951050
• A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies. PMID 36892457
• Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies. PMID 36603053
• A call to implement preclinical study registration in animal ethics review. PMID 37796782

Qualitative Research

• What are potential barriers and enablers to patient and physician participation in Canadian cell therapy trials for stroke? A stakeholder interview study. PMID 32198301
• So you want to give stem cells to babies? Neonatologists and parent's views to optimize clinical trials. PMID 31005276
• Navigating choice in the face of uncertainty: using a theory informed qualitative approach to identifying potential patient barriers and enablers to participating in an early phase chimeric antigen receptor T (CAR-T) cell therapy trial. PMID 33741670
• Understanding potential barriers and enablers to a perioperative early phase cell therapy trial. PMID 35396169
• Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies. PMID 36603053

Cohort Studies

• Building Canadian capacity for CAR-T cells in relapsed/refractory acute lymphoblastic leukemia: a retrospective cohort study. PMID 32688454
• Risk factors for failure to rescue in myocardial infarction after noncardiac surgery: a cohort study. PMID 32349069
• Association between frailty and patient outcomes after cancer surgery: a population-based cohort study. PMID 35034792

Patient Engagement

• Partnering with patients to get better outcomes with chimeric antigen receptor T-cell therapy: towards engagement of patients in early phase trials. PMID 33072399
• Patient engagement in preclinical laboratory research: A scoping review. PMID 34280783
• Making Patient Partnerships a Reality in Very Early Phase Clinical TriaLs (MARVEL)
• Recognizing patient partner contributions to health research: a mixed methods research protocol. PMID 35668479
• Building a platform for meaningful patient partnership to accelerate "bench-to-bedside" translations of promising new therapies. PMID 35467515
• Intraoperative pharmacologic opioid minimization strategies and patient-centred outcomes after surgery: a scoping review protocol. PMID 36858477
• Engaging patients in anesthesiology research: a rewarding frontier. PMID 36959493
• Protocol for co-producing a framework and integrated resource platform for engaging patients in laboratory-based research. PMID 38347658
• What guidance exists to support patient partner compensation practices? A scoping review of available policies and guidelines. PMID 38865184

Miscellaneous

• Systematic review and narrative review lead experts to different cancer trial predictions: a randomized trial. PMID 33346013
• Sex and gender-dependent differences in clinical and preclinical sepsis. PMID 33399356
• Biodistribution of mesenchymal stromal cell-derived extracellular vesicles administered during acute lung injury. PMID 37705086