Deborah Siegal profile picture

Contact Information

Deborah Siegal, MD MSc FRCPC
613-737-8899 x78804
dsiegal@toh.ca



ORCID logo https://orcid.org/0000-0003-3806-3245

Publications

Selected Publications

Little DHW, Cerasuolo J, Perez R, Douketis J, Holbrook A, Sutradhar R, Paterson M, Gomes T, Siegal DM. Resumption of Anticoagulant Therapy After Anticoagulant-Related Bleeding: A Population-Based Cohort Study. CMAJ. 2021 Mar 1;193(9):E304-E309.2.

Little DHW, Pinto T, Xenodemetropoulos T, Douketis J, Dionne J, Holbrook A, Siegal DM. Management of Antithrombotic Therapy After Gastrointestinal Bleeding: A Mixed Methods Study of Healthcare Providers. J Thromb Haemost. 2021 Jan;19(1):153-160.

Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, Mathur VS, Castillo J, Bronson MD, Leeds JM, Mar FA, Gold A, Crowther MA. Andexanet for Reversal of Factor Xa Inhibitor Activity. N Engl J Med. 2015 Dec 17;373(25):2413-24.

Connolly SJ, Crowther M, Eikelboom JW, Gibson CM, Curnutte JT, Lawrence JH, Yue P, BronsonMD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen AT, Beyer-Westendorf J,Albaladejo P, Lopez-Sendon J, Demchuk AM, Pallin DJ, Concha M, Goodman S, Leeds J, Souza S,Siegal DM, Zotova E, Meeks B, Ahmad S, Nakamya J, Milling TJ Jr; ANNEXA-4 Investigators. Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors. N Engl J Med.2019 Apr 4;380(14):1326-1335.

Siegal D, Yudin J, Kaatz, Douketis JD, Lim W, Spyropoulos AC. Periprocedural heparin bridging inpatients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding andthromboembolic rates. Circulation. 2012 Sep 25;126(13):1630-9.

All Other Publications

Peer-Reviewed Publications (out of total 123)

  1. Lun R, Siegal DM, Dowlatshahi D. Effect Modification of Age and Hypertension on Cancer & Prevalence of Self-Reported Stroke – A Cross Sectional Study (in press, Cancer Medicine)
  2. Siegal DM, Belley-Cote EP, Lee SF, Robertson T, Hill S, Benoit P, Meeks B, Owen J, Roglich T, Zotova E, Connolly SJ. Small-Volume Tubes to Reduce Anemia and Transfusion (STRATUS): A Pilot Study (in press, Can J Anesth)
  3. Eikelboom R, Siegal DM, Whitlock R, Belley-Cote E. Direct oral anticoagulants versus vitamin K antagonists in the first 3 months after bioprosthetic valve replacement: a systematic review and meta-analysis (in press European Journal of Cardio-Thoracic Surgery)
  4. Wang TY, Whed AS, Morrison A, Baumann Kreuzinger L, Quigley JG, Lamas GA, Weissman AJ, Lopez-Sendon J, Knudson M, Siegal DM et al. Effect of Thromboprophylaxis on Clinical Outcomes after COVID-19 Hospitalization: The ACTIV-4C Randomized Trial (in press Annals Int Med)
  5. Eikelboom R, Whitlock RP, Lopes RD, Siegal D, Jaffer IH, Drakos P, Schulman S, Belley-Côté EP. How Did We Get Here? Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Review. Thromb Haemost. 2023 Jan;123(1):6-15.
  6. Aziz J, Wang TF, Siegal D, Douketis J, Le Gal G, Carrier M, Shaw JR. Thrombotic and bleeding outcomes following the perioperative interruption of anticoagulation among patients with nonvalvular atrial fibrillation and active cancer. J Thromb Haemost. 2022 Dec 27:S1538-7836(22)18255-3.
  7. Caiano LM, Drury T, Zahrai A, Wang TF, Siegal DM, Rodger MA, Fournier K, Delluc A. Role of statins in the prevention of post-thrombotic syndrome after a deep vein thrombosis event: a systematic review and meta-analysis. J dsThromb Haemost. 2022 Dec 22:S1538-7836(22)18246-2. 
  8. Schenker C, Marx EC, Kraajpoel N, Le Gal G, Siegal DM, Klok FA, Aujesky D, Tritschler T. Definitions of fatal bleeding in clinical studies evaluating anticoagulant treatment for venous thromboembolism (in press J Thromb Haemost)
  9. Wang M, Swinton M, Troyan S, Ho J, S scoping reviiegal DM, Mbuagbaw L, Thabane L, M Holbrook A. Perceptions of patients and healthcare providers on patient education to improve oral anticoagulant management. J Eval Clin Pract. 2022 Dec;28(6):1027-1036.
  10. Lun R, Siegal DM, Ramsay T, Dowlatshahi D. Cancer and Stroke; What do we know and where do we go? Thrombosis Res. Thromb Res. 2022 Nov;219:133-140.
  11. Lun R, Roy DC, Hao Y, Deka R, Huang WK, Navi BB, Siegal DM, Ramsay T, Fergusson D, Shorr R, Dowlatshahi D. Incidence of Stroke in the First Year After Diagnosis of Cancer – A Systematic Review and Meta-Analysis. Front Neurol. 2022 Sep 20;13:966190.
  12. Chornenki N*, Tritschler T, Stucki F, Khan F, Ly V, Siegal DM. All-cause mortality after major gastrointestinal bleeding among patients receiving direct oral anticoagulants: a protocol for a systematic review and meta-analysis. Syst Rev. 2022 Dec 13;11(1):269. 
  13. Shaw JR, Castellucci L, Siegal DM, Carrier M. DOAC-Associated Bleeding, Hemostatic Strategies and Thrombin Generation Assays – A Review of the Literature. . J Thromb Haemost. 2022 Dec 22:S1538-7836(22)07643-7.
  14. Siegal DM, Freedman D, Ansell J. Urgent Procedures or Surgeries in Patients Receiving Oral Anticoagulants A Systematic Literature Review. J Thromb Thrombolysis. 2022 Dec 3.
  15. Wang M, Paterson M, Thabane L, Siegal D, Mbuagbaw L, Targownik K, Holbrook A. Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study. BMJ Open. 2022 Jun 13;12(6):e057991.
  16. Siegal DM, Leong DP. Evaluating Anticoagulant Strategies for Atrial Fibrillation in Patients with Cancer: Challenges and Opportunities. JACC CardioOncol. 2022 Sep 20;4(3):351-353.
  17. Ariëns RA, Hunt BJ, Agbani EO, Siegal DM, et al. Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress. Research and Practice in Thrombosis and Haemostasis. 2022 Jul 6;6(5):e127476.
  18. Holbrook AM, Vidug K, Yoo L, Troyan S, Schulman S, Douketis J, Thabane L, Giilck S, Koubaesh Y, Hyland S, Keshavjee K, Ho J, Tarride JE, Ahmed A, Talman M, Leonard B, Ahmed K, Refaei M, Siegal DM. Coordination of Oral Anticoagulant Care at Hospital Discharge (COACHeD): protocol for a pilot randomised controlled trial. Pilot Feasibility Stud. 2022 Aug 2;8(1):166.
  19. Morin J, Alayche M, Ghossein J, Delluc C, Siegal D, Wang TF, Delluc A. Source of upper gastrointestinal bleeding in cancer patients: A cross-sectional study. Thromb Res. 2022;217:9-11.
  20. Wang M, Paterson M, Thabane L, Siegal D, Mbuagbaw L, Targownik K, Holbrook A. Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study. BMJ Open. 2022 Jun 13;12(6):e057991.
  21. Bikdeli B, Tajrishi FZ, Sadeghipour P, Talasaz AH, Fanikos J, Lippi G, Siegal DM, Eikelboom JW, Monreal M, Jimenez D, Connors JM, Ageno W, Barnes GD, Piazza G, Angiolillo DJ, Parikh SA, Kirtane AJ, Lopes RD, Bhatt DL, Weitz JI, Mehran R, Krumholz, Goldhaber SZ, Lip GYH. Efficacy and Safety ConsiderationsWith Dose-Reduced Direct Oral Anticoagulants. JAMA Cardiol. 2022 Jul 1;7(7):747-759. doi: 10.1001/jamacardio.2022.1292.
  22. Akl E, Siegal DM et al,. A framework for the development of living practice guidelines in healthcare. Ann Intern Med. 2022 Aug;175(8):1154-1160. doi: 10.7326/M22-0514. 
  23. Nicholson M, Goubran H, Chan N, Siegal DM. No Apparent Association Between mRNA COVID-19 Vaccination and Venous Thromboembolism. Blood Rev. 2022 May 11;100970. doi: 10.1016/j.blre.2022.10097012.
  24. Den Exter P, Woller SC, Robert-Ebadi H, Masias C, Morange PE, Castelli D, Hasnsen JB, Geersing GJ, Siegal DM, de Wit K, Klok FA. Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease. J Thromb Haemost. 2022 Aug;20(8):1910-1919. doi: 10.1111/jth.1577613.
  25. Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, DeSancho MT, Diuguid DL, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo K, Siegal DM, et al. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients. Blood Adv. Blood Adv (2022) 6 (17): 4915–4923.
  26. Wang M, Swinton M, Troyan S, Ho J, Siegal D, Mbuagbaw L, Thabane L, M Holbrook A. Perceptions of patients and healthcare providers on patient education to improve oral anticoagulant management. J Eval Clin Pract. 2022 Feb 9. doi: 10.1111/jep.13665.
  27. Chornenki NLJ*, Siegal DM, Qamar K, Woolgar S, Rangarajan S, Karampatos S, Leong DP, Hillis CM. Characterizing Frailty In Myeloproliferative Neoplasms: results from the ORCHID study. Leuk Res. 2022 Jan 11;113:106788. doi: 10.1016/j.leukres.2022.106788.
  28. Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, Davila J, DeSancho MT, Diuguid DL, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo K, Siegal DM, et al. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on post-discharge thromboprophylaxis. Blood Adv. 2022 Jan 25;6(2):664-671. doi:10.1182.
  29. Lun R, Roy DC, Ramsay T, Siegal D, Shorr R, Fergusson D, Dowlatshahi D. Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis. PLoS One. 2021 Sep 1;16(9):e0256825.
  30. Holbrook A, Wang M, Swinton M, Troyan S, Ho JMW, Siegal DM. Barriers and facilitators for optimizing oral anticoagulant management: Perspectives of patients, caregivers, and providers. PLoS One. 2021 Sep 29;16(9):e0257798. doi: 10.1371/journal.pone.0257798.
  31. Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, Davila J, DeSancho MT, Diuguid DL, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo K, Siegal DM, et al. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate intensity anticoagulation in critically ill patients. Blood Adv. Blood Adv (2021) 5 (20): 3951–3959.
  32. Tran A, Fernando SM, Carrier M, Siegal DM, Inaba K, Vogt K, Engels PT, English SW, Kanji S, Kyeremanteng K, Lampron J, Kim D, Rochwerg B. Efficacy and Safety of Low Molecular Weight Heparin versus Unfractionated Heparin for Prevention of Venous Thromboembolism in Trauma Patients – A Systematic Review and Meta-Analysis. Ann Surg. 2021 Aug 13. doi: 10.1097/SLA.0000000000005157.
  33. Tran A, Fernando SM, Rochwerg B, Cook DJ, Crowther MA, Fowler RA, Alhazzani W, Siegal DM, Castellucci LA, Zarychanski R, English SW, Kyeremanteng K. Prognostic Factors Associated with Development of Venous Thromboembolism in Critically Ill Patients – A Systematic Review and Meta-Analysis. Crit Care Med. 2022 Apr 1;50(4):e370-e381. doi: 10.1097/CCM.0000000000005382.
  34. Wang TF, Carrier M, Fournier K, Siegal DM, Le Gal G, Delluc A. Oral anticoagulant use in patients with morbid obesity: A systematic review and meta-analysis. Thromb Haemost. 2021 Aug 16. doi: 10.1055/a-1588-9155. Online ahead of print.
  35. Fernando SM, Mathew R, Munshi L, Siegal DM, Carrier M, Wells PS, Brodie D. Media Portrayals of Pulmonary Embolism. Thromb Res. 2021 Aug 11;206:52-54. doi: 10.1016/j.thromres.2021.08.006. Online ahead of print.
  36. Lawler et al on behalf of The ATTACC, ACTIV-4a, and REMAP-CAP Investigators. Therapeutic Anticoagulation in Non-Critically Ill Patients with Covid-19. In press, NEJM.
  37. Goligher et al on behalf of the ATTACC, ACTIV-4a and REMAP-CAP Investigators. Therapeutic Anticoagulation in Critically Ill Patients with Covid-19. In press, NEJM. doi: 10.1101/2021.03.10.21252749.
  38. Xu Y*, Siegal DM. Anticoagulant-associated gastrointestinal bleeding: Framework for decisions about whether, when and how to resume anticoagulants. J Thromb Haemost. 2021 Oct;19(10):2383-2393. doi: 10.1111/jth.15466.
  39. Chornenki NLJ*, Poorzargar K, Shanjer M, Mbuagbaw L, Delluc A, Crowther M, Siegal DM. Detection of right ventricular dysfunction in acute pulmonary embolism by computed tomography or echocardiography: A systematic review and meta-analysis. J Thromb Haemost. 2021 Oct;19(10):2504-2513. doi: 10.1111/jth.15453.
  40. Ikesaka R, Siegal DM, Wang TF, Webb C, Witham D, Malik R, Carrier. M. Thromboprophylaxis with Rivaroxaban In Patients with Malignancy and Central Venous Lines (TRIM-line): A Two-centre Open-Label Pilot Randomized Controlled Trial. Res Pract Thromb Haemost. 2021 May 5;5(4):e12517. doi: 10.1002/rth2.12517.
  41. Siegal DM, Anand S. Considerations for use of direct oral anticoagulants in arterial disease. Res Pract Thromb Haemost. 2021 May 28;5(4):10.1002/rth2.12502. 
  42. Milling TJ, King B, Yue P, Middeldorp S, Beyer-Westendorf J, Eikelboom JW, Crowther M, Xu L, Vehamme P, Siegal D, Connolly SJ. Restart of anticoagulant therapy and risk of thrombosis, rebleeding and death after factor Xa inhibitor reversal in major bleeding patients. Thromb Haemost. 2021 Aug;121(8):1097-1106. 
  43. Wang M, Chen Z, Wong M, Thabane L, Mbuagbaw L, Siegal DM, Le Gal G, Holbrook A. Are the correct outcomes being measured in studies of oral anticoagulants? A systematic survey. Thromb Res. 2021 Feb 18;201:30-49.
  44. Leong D, Aghel N, Hillis C, Siegal D, Karampatos S, Rangarajan S, Pond G, Seow H. Tyrosine kinase inhibitors in chronic myeloid leukaemia and emergent cardiovascular disease. Heart. 2021 Apr;107(8):667-673.
  45. Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dube KD, Davila J, DeSancho MT, Diuguid D, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Pai M, Righini M, Sanfilippo K, Siegal D, et al. American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19. Blood Adv. 2021 Feb 9;5(3):872-888.
  46. Little DHW*, Cerasuolo J, Perez R, Douketis J, Holbrook A, Sutradhar R, Paterson M, Gomes T, Siegal DM. Resumption of Anticoagulant Therapy After Anticoagulant-Related Bleeding: A Population-Based Cohort Study. CMAJ. 2021 Mar 1;193(9):E304-E309.
  47. Little DHW*, Pinto T, Xenodemetropoulos T, Douketis J, Dionne J, Holbrook A, Siegal DM. Management of Antithrombotic Therapy After Gastrointestinal Bleeding: A Mixed Methods Study of Healthcare Providers. J Thromb Haemost. 2021 Jan;19(1):153-160.
  48. Siegal DM. Ciraparantag: The Next Anticoagulant Airbag? Blood. 2021 Jan 7;137(1):10-11.
  49. Xu Y*, Siegal DM, Anand S. Ethnoracial variations in venous thrombosis: implications for management, and a call to action. J Thromb Haemost. 2021 Jan;19(1):30-40.
  50. Siegal DM, Eikelboom JW, Lee SF, Rangarajan S, Bosch J, Zhu J, Yusuf S; Venous Thromboembolism Collaboration. Variations in incidence of venous thromboembolism in low-, middle-, and high-income countries. Cardiovasc Res. 2021 Jan 21;117(2):576-584.
  51. Roshanov PS, Guyatt GH, Tandon V, Borges FK, Lamy A, Whitlock R, Biccard BM, Szczeklik W, Panju M, Spence J, Garg AX, McGillion M, Eikelboom JW, Sessler DI, Kearon C, Crowther M, VanHelder T, Kavsak PA, de Beer J, Winemaker M, Le Manach Y, Sheth T, Pinthus JH, Siegal D, Thabane L, Simunovic MRI, Mizera R, Ribas S, Devereaux PJ. Preoperative prediction of Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS): an international prospective cohort study. Br J Anaesth. 2021 Jan;126(1):172-180.
  52. Roshanov P, Guyatt GH, Tandon V, Kessler Borges F, Lamy A, Whitlock R, Biccard BM, Szczeklik W, Panju M, Spence J, Garg AX, McGillion M, Eikelboom JW, Sessler DI, Kearon C, Crowther MA, VanHelder T, Kavsak PA, de Beer J, Winemaker M, Le Manach Y, Sheth T, Pinthus JH, Siegal D, et al. Bleeding independently associated with mortality after noncardiac surgery (BIMS): An international prospective cohort study establishing diagnostic criteria and prognostic importance. Br J Anaesth. 2021 Jan;126(1):163-171.
  53. Siegal DM, Manning N*, Chornenki NLJ*, Heddle N, Hillis CM. Devices to reduce the volume of blood taken for laboratory testing in ICU patients: a systematic review J Intensive Care Med. 2020 Oct;35(10):1074-1079.
  54. Siegal DM, Barnes GD, Langlois NJ, Lee A, Middeldorp S, Skeith L, Wood WA, Le Gal G. Toolkit for the Collection of Thrombosis-Related Data Elements in COVID-19 Clinical Studies. Blood Adv. 2020 Dec 22;4(24):6259-6273.
  55. Tomaselli GF, Mahaffey KW, Cuker A, Dobesh PP, Doherty JU, Eikelboom JW, Florido R, Gluckman T, Hucker W, Mehran R, Messe SR, Perino A, Rodriguez F, Sarode R, Siegal D, Wiggins BS. 2020 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants. A Report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways. J Am Coll Cardiol 2020 Aug 4;76(5):594-622.
  56. Siegal DM, Gross P. Narrowing in on the true rate of venous thromboembolism in hospitalized patients with COVID-19 disease. Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):1958-1960.
  57. Gowanlock Z*, Lezhanska A, Conroy M, Tiboni M, Mbuagmaw L, Siegal DM. Iron deficiency following bariatric surgery: a retrospective cohort study. Blood Adv. 2020;4(15):3639-3647.
  58. Montrief T, Haas M, Alvarez A, Gottlieb M, Siegal D, Chan T. Thinking outside the Inbox: Use of Slack in clinical groups as a collaborative team communication platform. AEM Education and Training. 2020 Jul 28;5(1):121-129. doi: 10.1002/aet2.10497. eCollection 2021 Jan.
  59. Shaw JR*, Siegal DM. Prothrombin Complex Concentrates for DOAC-Associated Bleeding, Global Coagulation Essays and Assessments of Clinical Hemostasis: How to Gauge the Impact? Res Pract Thromb Haemost. 2020;4(5):677-679.
  60. den Exter PL, Kroft LJM, Gonsalves C, Le Gal G, Schaefer-Prokop CM, Carrier M, Huisman MV, Klok FA, Meijboom L, Beenen LF, de Roos A, Hartmann I, Dennie C, Revel MP, Haramati L, van Beek E, Screaton N, Ferretti G, Ghaye B, Das M, White C, Pena Fernandez E, Paul N, Vlahos I, Renapurkar RD, Ravenel J, Kanne J, Abbara S, Rémy-Jardin M, Geurts B, Frauenfelder T, Sverzellati N, Prosch H, Goo JM, Vogel-Claussen J, MacMahon PJ, Bhalla S, Kahn S, Shivakumar S, Wells P, Rodger M, Castellucci L, Duffett L, Delluc A, Siegal D et al. Establishing diagnostic criteria and treatment of subsegmental pulmonary embolism: A Delphi analysis of experts. Res Pract Thromb Haemost 2020 Oct 1;4(8):1251-1261.
  61. Gupta S, Panchal P, Gilotra K, Wilfred AM, Hou W, Siegal D, Whitlock RP, Belley-Cote EP. Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: a systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2020 Aug 1;31(2):141-151.
  62. Siegal DM, Healey JS. Shared Decision-Making for Stroke Prevention in Atrial Fibrillation: Do Physicians Really Listen? Can J Cardiol. 2020 Apr;36(4):459-461.
  63. Chornenki NJ*, James T, Barty R, Liu Y, Rochwerg B, Heddle N, Siegal DM. Blood loss from laboratory testing, anemia and red blood cell transfusion in the intensive care unit: a retrospective study. Transfusion. 2020 Feb;60(2):256-261.
  64. Verbrugge FJ, Martin AC, Siegal DM, Pieper K, Illingworth L, Camm JA, Fox KAA. Impact of Oral Anticoagulation in Atrial Fibrillation Patients at Very Low Thromboembolic Risk.  Heart. 2020 Jun;106(11):845-851.
  65. Abdulrehman J*, Eikelboom JW, Siegal DM. Andexanet alfa for reversal of factor Xa inhibitors: a critical review of the evidence. Future Cardiol. 2019 Nov;15(6):395-404.
  66. Spyropoulos A, Brohi K, Caprini J, Samama M, Siegal DM, Tafur A, Verhamme P, Douketis J. Scientific and Standardization Committee Communication: Guidance document on the periprocedural management of patients on chronic oral anticoagulant therapy: recommendations for standardized reporting of patient-specific thromboembolic risk and procedural/surgical bleed risk. J Thromb Haemost. 2019 Nov;17(11):1966-1972.
  67. Siegal DM. What Have We Learned About DOAC Reversal? Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):198-203.
  68. Kimpton M*, Siegal DM. Mortality and thrombosis in patients receiving PCC or andexanet for direct factor Xa inhibitor-associated major bleeding. Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):204-208.
  69. Behnood B, Jimenez D, Garcia-Tsao G, Barba R, Font C, del Carmen Diaz-Pedroche M, Mazzolai, Little D, Tufano A, Tafur A, Siegal DM, Lip GYH, Monreal M for the RIETE Investigators. Venous thromboembolism in patients with liver cirrhosis: findings from the RIETE Registry Semin Thromb Hemost. 2019 Nov;45(8):793-801.
  70. Mrkobrada M, Chan MTV, Cowan D, Campbell D, Wang CY, Torres D, Malaga G, Sanders RD, Sharma M, Brown C, Sigamani A, Szczeklik W, Sharma M, Guyatt G, Smith EE, Agid R, Dmytriw AA, Spence J, Adunuri NR, Borges FK, Short TG, Hill MD, Saad F, Copland I, Pettit S, Ibrahim Q, Bangdiwala SI, Yusuf S, Tsai S, Sahlas DJ, Mensinkai A, Sposato LA, Hussain S, Yang S, Siegal D, et al. Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. Lancet. 2019 Sep 21;394(10203):1022-1029.
  71. Chornenki NLJ*, Um KJ*, Mendoza PA*, Samienezhad A, Swarup V, Chai-Adisaksopha C, Siegal DM. Risk of venous and arterial thrombosis in non-surgical patients receiving systemic tranexamic acid: A systematic review and meta-analysis. Thromb Res. 2019 May 5;179:81-86.
  72. Nham T*, Saleh C*, Chu D, Vakaljan SL, Ohayon JA, Siegal DM. Refractory urticaria and the importance of diagnosing Schnitzler’s syndrome. BMJ Case Rep. 2019 Apr 29;12(4).
  73. Little D*, Siegal DM. Resumption of anticoagulant therapy after anticoagulant-related gastrointestinal bleeding. Thromb Res. 2019; 180: 86.
  74. Little D*, Chai-Adisaksopha C, Hillis C, Witt D, Monreal M, Crowther M, Siegal DM. Resumption of Anticoagulant Therapy after Anticoagulant-Related Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis. Thromb Res. 2019 Mar;175:102-109.
  75. Connolly SJ, Crowther M, Eikelboom JW, Gibson CM, Curnutte JT, Lawrence JH, Yue P, Bronson MD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen AT, Beyer-Westendorf J, Albaladejo P, Lopez-Sendon J, Demchuk AM, Pallin DJ, Concha M, Goodman S, Leeds J, Souza S, Siegal DM, Zotova E, Meeks B, Ahmad S, Nakamya J, Milling TJ Jr; ANNEXA-4 Investigators. Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors. N Engl J Med. 2019 Apr 4;380(14):1326-1335.
  76. Siegal DM, Connolly SJ. Idarucizumab for GI Bleeds on Dabigatran. Circulation. 2019 Feb 5;139(6):757-759.
  77. De Caterina R, Ageno W, Agnelli G, Chan N, Diener H-C, Hylek E, Raskob G, Siegal D, Verheugt F, Lip G, Weitz J. The non-vitamin K antagonist oral anticoagulants in heart disease: special situations. Thromb Haemost. 2019 Jan;119(1):14-38.

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