Kwame Twumasi-Boateng, Jessica L. Pettigrew, Y. Y. Eunice Kwok,
John C. Bell & Brad H. Nelson. Oncolytic viruses as engineering platforms for combination immunotherapy.
Nature Reviews Cancer. Published online: 25 April 2018. doi:10.1038/s41568-018-0009-4.
Free full text.
Bourgeois-Daigneault MC, Roy DG, Aitken AS, El Sayes N, Martin NT, Varette O, Falls T, St-Germain LE, Pelin A, Lichty BD, Stojdl DF, Ungerechts G, Diallo JS and
Bell JC. Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy.
Sci Transl Med. 2018 Jan 3;10(422). Free full text.
Rozanne Arulanandam, Cory Batenchuk, Fernando A. Angarita, Kathryn Ottolino-Perry, Sophie Cousineau, Amelia Mottashed, Emma Burgess, Theresa J. Falls, Naomi De Silva, Jovian Tsang, Grant A. Howe, Marie-Claude Bourgeois-Daigneault, David P. Conrad, Manijeh Daneshmand, Caroline J. Breitbach, David H. Kirn, Leda Raptis, Subash Sad, Harold Atkins, Michael S. Huh, Jean-Simon Diallo, Brian Lichty, Carolina S. Ilkow, Fabrice Le Boeuf, Christina L. Addison, J. Andrea Mc Cart and
John C. Bell. VEGF-mediated induction of PRD1-BF1/Blimp1 expression sensitizes tumour vasculature to oncolytic virus infection.
Cancer Cell. 2015 Aug 10;28(2):210-24.
Carolina S. Ilkow, Monique Marguerie, Cory Batenchuk, Justin Mayer, Daniela Ben Neriah, Sophie Cousineau, Theresa Falls, Victoria Jennings, Meaghan Boileau, David Bellamy1, Donald Bastin1, Christiano Tanese de Souza1, Almohanad Alkayyal1, Jiging Zhang, Fabrice LeBoeuf1, Rozanne Arulanandam, Lawton Stubbert, Padma Sampath, Steve Thorne4, Piriya Paramanthan5, Avijit Chatterjee5, Robert M. Strieter, Marie Burdick, Christina Addison David F. Stojdl, Harold L. Atkins, Rebecca Auer, , Jean-Simon Diallo, Brian Lichty, and
John C. Bell. Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.
Nat Med. 2015 May;21(5):530-6.
Brian D. Lichty, Caroline J. Breitbach, David F. Stojdl, &
John C. Bell. Going viral with cancer immunotherapy.
Nature Reviews Cancer. 2014 03 July.
Fabrice Le Bœuf*, Cory Batenchuk*, Markus Vähä-Koskela, Sophie Breton, Dominic Roy, Chantal Lemay, Julie Cox, Hesham Abdelbary, Theresa Falls, Girija Waghray, Harold Atkins, David Stojdl, Jean-Simon Diallo, Mads Kaern,
John Bell. Model-based Rational Design of an Oncolytic Virus with Improved Therapeutics Potential.
Nature Communications 2013 Jun 14;4:1974.
Heo, J.,Reid, T., Ruo, L., Breitbach, C.,Rose, S., Bloomston, M., Cho, M., Lim, H.Y., Chung, H.C., Kim, C.W., Burke, J.,Lencioni, R., Hickman, T., Moon, A., Lee, Y.S., Kim, M.K., Daneshmand, M., Dubois, K., Longpre, L., Ngo, M., Rooney, C.,
Bell, J.C.,Rhee,B-G., Patt, R., Hwang, T-H., Kirn, D.H., (2013) Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX 594 in liver cancer.
Nat Med. 2013 Mar;19(3):329-36.
All Other Publications
Marie-Eve Wedge*, Victoria A. Jennings*, Mathieu Crupi*, Joanna Poutou*, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, Dave Mansfield, Elaine Rose, Emily E.F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher,
John C. Bell and Carolina S. Ilkow. “Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy”.
Nature Communications 2022 Apr 7;13(1):1898.
Stephen Boulton*, Joanna Poutou*, Nikolas T. Martin*, Taha Azad*, Ragunath Singaravelu*, Mathieu J.F. Crupi*, Taylor Jamieson*, Xiaohong He, Ricardo Marius, Julia Petryk, Christiano Tanese de Souza, Bradley Austin, Zaid Taha, Jack Whelan, Sarwat T. Khan, Adrian Pelin, Reza Rezaei, Abera Surendran, Sarah Tucker, Emily E. F. Brown, Jaahnavi Dave, Jean-Simon Diallo, Rebecca Auer, Jonathan B. Angel, D. William Cameron, Jean-Francois Cailhier, Réjean Lapointe, Kyle Potts, Douglas J. Mahoney,
John C. Bell, Carolina S. Ilkow. Single dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection.
Mol Ther. 2022 May 4;30(5):1885-1896.
Taha Z, Arulanandam R, Maznyi G, Godbout E, Carter-Timofte ME, Kurmasheva N, Reinert LS, Chen A, Crupi MJF, Boulton S, Laroche G, Phan A, Rezaei R, Alluqmani N, Jirovec A, Acal A, Brown EEF, Singaravelu R, Petryk J, Idorn M, Potts KG, Todesco H, John C, Mahoney DJ, Ilkow CS, Giguère P, Alain T, Côté M, Paludan SR, Olagnier D,
Bell JC, Azad T, Diallo JS. Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen.
Mol Ther. 2022 Sep 7;30(9):2998-3016.
Jack T Whelan*,, Ragunath Singaravelu*, Fuan Wang*, Adrian Pelin*,, Levi A Tamming,, Giuseppe Pugliese,, Nikolas T Martin,, Mathieu JF Crupi,, Julia Petryk,, Bradley Austin,, Xiaohong He,, Ricardo Marius,, Jessie Duong,, Carter Jones,, Emily EF Fekete, Nouf Alluqmani, Andrew Chen,, Stephen Boulton,, Michael Huh,, Matt Tang,, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D Lichty, Carolina S Ilkow,
John C Bell. CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX.
Front Immunol. 2023 Jan 13;13:1050250.
Crupi MJF, Taha Z, Janssen TJA, Petryk J, Boulton S, Alluqmani N, Jirovec A, Kassas O, Khan ST, Vallati S, Lee E, Huang BZ, Huh M, Pikor L, He X, Marius R, Austin B, Duong J, Pelin A, Neault S, Azad T, Breitbach CJ, Stojdl DF, Burgess MF, McComb S, Auer R, Diallo JS, Ilkow CS,
Bell JC. Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer.
Front Immunol. 2022 Nov 3;13:1029269.
Boulton S, Crupi MJF, Singh S, Carter-Timofte ME, Azad T, Organ BC, He X, Gill R, Neault S, Jamieson T, Dave J, Kurmasheva N, Austin B, Petryk J, Singaravelu R, Huang BZ, Franco N, Babu K, Parks RJ, Ilkow CS, Olagnier D,
Bell JC. Inhibition of Exchange Proteins Directly Activated by cAMP (EPAC) as a Strategy for Broad-spectrum Antiviral Development.
J Biol Chem. 2023 Apr 24:104749.
Nikolas T Martin*, Mathieu JF Crupi*, Zaid Taha, Joanna Poutou, Jack T Whelan, Sydney Vallati, Julia Petryk, Ricardo Marius, Bradley Austin, Taha Azad, Mason Boulanger, Tamara Burgess, Ilson Sanders, Camille Victoor, Bryan C Dickinson, Jean-Simon Diallo, Carolina S Ilkow,
John C Bell. Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy.
Pharmaceuticals 2023 May;16 (5), 709.
Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu JF Crupi, Huy-Dung Hoang, Abolfazl Nik-Akhtar, Mahsa Ahmadi, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C Dickinson, Lee-Hwa Tai, Carolina S Ilkow,
John C Bell. Synthetic virology approaches to improve the safety and efficacy of Oncolytic virus therapies.
Nature Communications, (2023)14 (1),3035.
