Our research focuses on manufacturing enabling activities, such as process and assay development, for therapeutic viruses.

Process Development

We have capacity and experience with a variety of both upstream and downstream approaches to optimize virus growth and purification including:

• Adherent bioreactors (static culture and fixed bed bioreactors like iCELLis)
• Suspension bioreactors (1-200L)
• Tangential flow filtration (TFF)
• Chromatography

As part of our process development approach, we also implement cost and time-saving strategies such as Design of Experiment (DoE), a multi-factorial, statistical approach that rationally tests combinations of factors most likely to impact process parameters using as few experiments as possible. All of our process development equipment is purposefully scaled to what is used in our GMP production suites to ensure seamless technology transfer for projects destined for manufacture.

Assay Development

We specialize in the development of product-specific assays such as potency and identity for the therapeutic viruses we manufacture using the following approaches:

• Western Blot
• ELISA
• PCR
• Titer by plaque assay
• Functional titer by transduction and qPCR