Since
2000, I have pursued work as a physician-scientist focusing on Parkinson
disease (PD), Lewy body dementia (DLB) and multiple system atrophy (MSA). Since opening my new laboratory at the OHRI in
2007, my team has focused on: (i) to investigate the pathogenesis of different forms of parkinsonism, such as late- vs. young-onset PD and delineate disease mechanisms; in this effort, we are led by autopsy findings. (ii) to build new animal models that restage aspects of neuropathology that are linked to mutations in one of four PD-associated genes. (iii) to develop a simple-to-impute formula for PD risk (PREDIGT Score) that is based on five risk categories and could enable an early diagnosis, even independent of a neurologist.
Li J, Mestre TA, Mollenhauer B, Frasier M, Tomlinson JJ, Trenkwalder C, Ramsay T, Manuel D, Schlossmacher MG. Evaluation of the PREDIGT score's performance in identifying newly diagnosed Parkinson's patients without motor examination. NPJ Parkinsons Dis. 2022 Jul 29;8(1):94. doi: 10.1038/s41531-022-00360-5. PMID: 35906250; PMCID: PMC9338052.
Schlossmacher MG, Graybiel A. Conversations with Dr. Oleh Hornykiewicz, Founding Father of the Dopamine Era in Parkinson’s: How Do You Wish to be Remembered? Mov Disord. 2020 Nov;35(11):1922-1932. doi: 10.1002/mds.28316. Epub 2020 Oct 14. PMID: 33053225; PMCID: PMC7756664.
Tokarew, Jacqueline M., et al. "Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites." Acta neuropathologica 141.5. 2021; 725-754.
Oliveira, Luis, et al. "Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease." npj Parkinson's Disease 7.1. 2021; 1-23.
Sircar, Esha, et al. "Neurodegeneration: Impact of S-nitrosylated Parkin, DJ-1 and PINK1 on the pathogenesis of Parkinson's disease." Archives of Biochemistry and Biophysics 704. 2021; 108869.
Sanyal, Anwesha, et al. "Lysosome and inflammatory defects in GBA1-mutant astrocytes are normalized by LRRK2 inhibition." Movement Disorders 35.5 2020; 760-773.
Shutinoski B, et al. Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner. Sci Transl Med. 2019 Sep 25;11(511). pii: eaas9292. doi: 10.1126/scitranslmed.aas9292.
Tomlinson JJ et al. Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects. J Neural Transm 2017; 124(6): 721-738
Schlossmacher MG et al. Modelling idiopathic Parkinson disease as a
complex illness can inform incidence rate in healthy adults : the PREDIGT
score. Eur J Neuroci. 2017;
45(1) :175-191
Cullen V* et al. Acid beta-glucosidase mutations linked to Gaucher disease, Parkinson's and Lewy body dementia dysregulate alpha-synuclein in vivo. Ann Neurol 2011;69:940-53
*This paper was awarded the editor's ‘Annals of Neurology Prize' in 2012
Hakimi M et al. Parkinson's-linked
LRRK2 is expressed in immune cells and upregulated after the recognition of
microbial structures. J Neural
Transm 2011;118:795-808
Mollenhauer B* et al. Cerebrospinal fluid values of alpha-synuclein and tau in patients
presenting with parkinsonism. Lancet Neurol
2011;10:230-40 and Lancet Neurol 2011;10:681-3;
*See also the opinion piece published
in: Lancet Neurol 2011;10(3):203-5
The Schlossmacher team unites a group of trainees, research staff and collaborators from diverse scientific interests and backgrounds - including neuroscience, biochemistry, immunology, virology, animal studies and pathology. This reflects our different approaches to studying and modelling Parkinson disease variants and related dementias.
Potential trainees, please send inquiries to: jtomlinson@ohri.ca
