Dr. Sorisky's research interest is cell-surface receptor signal transduction in the context of adipose cell responses, such as differentiation, proliferation, survival, and adipokine production. His research group uses primary human adipose cells from patients and established cell lines to understand how disturbances in adipose cell signal transduction networks, regulated by cell-surface tyrosine kinase or G protein-coupled receptors, result in metabolic malfunction such as insulin resistance and inflammation. Through this line of inquiry, he aims to understand the molecular processes that link adipose tissue dysfunction with cardiovascular disease and type 2 diabetes