Tumour engineering could provide a powerful new approach to make more cancer patients eligible for targeted immunotherapies
September 26, 2024 - There are many highly-effective immunotherapies available in the clinic, but few cancer patients are eligible for these treatments because their tumours must have specific targetable proteins. A new tumour engineering approach could help. |
Beyond the spike: novel COVID vaccine candidate targets 7 viral proteins for strong immune response
November 2, 2023 - Despite the widespread availability of COVID-19 vaccines in many countries, SARS-CoV-2 continues to spread and make people sick and new variants remain a significant threat.
Researchers at The Ottawa Hospital and the University of Ottawa believe ... |
Next-generation cancer-fighting viruses could be fine-tuned with a pill
June 2, 2023 - Cancer-fighting (oncolytic) viruses can infect and kill cancer cells without harming normal tissues, while also delivering therapeutic / toxic genes to tumours and stimulating an anti-cancer immune response. |
Bringing cellular immunotherapy to solid tumours: made-in-Canada approach to be pioneered in biliary tract cancers thanks to $7.4M grant
April 13, 2023 - Canadians with biliary tract cancer (cholangiocarcinoma and gallbladder) will have the first chance to benefit from a new made-in-Canada approach to personalized cellular immunotherapy, thanks to a $7.4 million grant from the Canadian Cancer ... |
From a project to a platform: A new and less expensive way to deliver immunotherapy
April 5, 2023 - Exosomes are a promising vehicle for delivering immunotherapies for many reasons. They can target specific cells or tissues, their contents are protected from degradation, there is no danger of rejection by the host, and as vehicles for cell ... |
Potential colorectal cancer treatment combines immunotherapy and viral therapy in a powerful new way
February 16, 2023 - Immunotherapy is revolutionizing the treatment of many kinds of cancer, but for colorectal cancer, success has been limited to patients with rare genetic mutations. To tackle this challenge, researchers at The Ottawa Hospital engineered a new ... |
Anti-fungal drug shows promise against COVID-19 in lab studies
August 18, 2022 - Researchers at The Ottawa Hospital have discovered that a common anti-fungal drug can protect against COVID-19 in laboratory models. The drug, called bifonazole, blocks the interaction between the viral spike protein and its cell-surface receptor ... |
Researchers at The Ottawa Hospital awarded 19 CIHR grants worth more than $12 million
July 20, 2022 - These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, ... |
Cancer-fighting viruses soften up their victims before attacking
April 7, 2022 - A research team based at The Ottawa Hospital and the University of Ottawa has developed a virus that infects and kills cancer cells without harming normal cells, while also sending out signals to prepare nearby uninfected cancer cells for viral ... |
Made-in-Ottawa vaccine could help in global fight against COVID-19, including new variants
December 13, 2021 - As the COVID-19 virus continues to spread around the world, a vaccine developed and manufactured at The Ottawa Hospital could provide a unique approach to help control the pandemic. Unlike the COVID-19 vaccines currently approved by the World ... |
Biotherapeutics: the future of medicine
May 25, 2021 - World-class biotherapeutics facility at The Ottawa Hospital uses cells, genes and viruses to create unique life-saving treatments |
Vaccines and viral immunotherapies: unique Canadian program provides training to manufacture biotherapeutics
November 21, 2020 - As COVID-19 highlights the urgent need to increase vaccine manufacturing around the world, a unique training program is bolstering Canada’s capacity to manufacture vaccines, as well as viral immunotherapies for cancer and other emerging ... |
$1M grant to support manufacturing of COVID-19 treatments and vaccines at The Ottawa Hospital and uOttawa
November 6, 2020 - Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $1,050,000 from the Canada Foundation for Innovation to support facilities for manufacturing innovative treatments and vaccines for COVID-19. |
From “what if” to “what is”
October 9, 2020 - What if you could deliver just one product, in this case one cancer-killing (or oncolytic) virus, to any kind of cancer and have that virus turn into something customized to kill one particular cancer –your own. |
Harnessing cancer-fighting viruses to develop a COVID-19 vaccine
June 25, 2020 - Drs. Carolina Ilkow, John Bell and colleagues are harnessing their expertise in making oncolytic (cancer-fighting) viruses to develop a vaccine against COVID-19, in partnership with scientists and clinicians in Canada and around the world. |
The Ottawa Hospital awarded $4.7 million for COVID-19 research from the Canadian Institutes of Health Research
June 25, 2020 - Researchers at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded $4.7 million from the Canadian Institutes of Health Research (CIHR) for four research projects that could transform our understanding of COVID-19 and ... |
Cancer-killing viruses provide inspiration for COVID-19 vaccine
April 28, 2020 - While physical distancing has slowed the spread of COVID-19, the vast majority of people around the world remain susceptible to the virus. That’s why most experts believe we won’t be able to fully find a new normal until a vaccine is developed. ... |
Researchers join the fight against COVID-19
April 2, 2020 - As hospitals and communities band together to fight COVID-19, researchers at The Ottawa Hospital are harnessing their unique expertise and resources to help. |
Researchers uncover possible new mechanism to enhance cancer-killing viruses
July 11, 2018 - Cancer-killing (oncolytic) viruses have shown promise in the lab and the clinic, but they don’t always work. New research led by Dr. Carolina Ilkow could help change this. While normal cells often lose their first line of antiviral defenses when ... |
Top Research Papers from The Ottawa Hospital 2015-2017
June 7, 2018 - Did you know that researchers at The Ottawa Hospital publish an average of four new scientific papers every single day? Our research is advancing science and improving health on a massive scale – both at home and around the world. The list below ... |
MS drug makes cancer-fighting viruses more effective in lab models
February 7, 2018 - A drug used to treat multiple sclerosis and psoriasis can dramatically enhance the spread of cancer-fighting viruses in human tumour samples and animal models, according to a study published in Science Translational Medicine. A team led by Dr. Jean |
The Ottawa Hospital awarded 18 research grants from the Canadian Institutes of Health Research, worth $10.7 million
May 19, 2017 - Eighteen research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded nearly $11 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). This represents a suc |
Pancreatic cancer loses viral defences when talking with supporting cells
April 20, 2015 - Ottawa researchers have unlocked a way to make pancreatic cancer cells more vulnerable to cancer-killing viruses, known as oncolytic viruses. Outlined in a paper published today by Nature Medicine, the scientists have discovered how they can exploit |
