Lab study provides new hope for people with rare muscle disease
August 29, 2024 - Researchers from The Ottawa Hospital and uOttawa played a key role in a study that could lead to a new understanding of facioscapulohumeral muscular dystrophy (FSHD). |
When the hangman isn't hanging: how cell death proteins might protect against ALS
August 18, 2023 - For more than 30 years, caspases have been known as tiny cellular executioners, just waiting for a signal to chop up a cell’s proteins and initiate what is known as “programmed cell death.” |
Cancer cells break their own DNA to buy time to repair radiation damage
April 28, 2022 - A research team from Europe and Canada has discovered that cancer cells break their own DNA in a controlled, reversible way to buy time to repair the massive DNA damage that occurs during radiation treatment. Their research, published in top ... |
Researchers at The Ottawa Hospital awarded 17 CIHR grants worth $7.5 million
March 10, 2021 - Researchers at The Ottawa Hospital are playing a lead role in 17 new projects funded by the Canadian Institutes of Health Research (CIHR). |
The Ottawa Hospital awarded nine grants worth $5.6 million from Canadian Institutes of Health Research
February 3, 2020 - How can we treat depression when nothing else is working? How can heart growth be both good and bad? How can we increase patient participation in clinical trials? These are just a few of the big questions that researchers at The Ottawa Hospital ... |
Research shows how good heart growth turns bad
January 30, 2019 - More than 17 percent of Canadians have been diagnosed with high blood pressure, a condition that makes it more difficult for the heart to pump blood around the body. At first, heart muscle grows to meet the challenge, but eventually this growth ... |
Top Research Papers from The Ottawa Hospital 2015-2017
June 7, 2018 - Did you know that researchers at The Ottawa Hospital publish an average of four new scientific papers every single day? Our research is advancing science and improving health on a massive scale – both at home and around the world. The list below ... |
Patent brings possible new heart failure treatment closer to reality
May 30, 2018 - Drs. Lynn Megeney, Duncan Stewart, Colin Suen, and Mohammad Abdul-Ghani have been granted a U.S. patent for an experimental approach to treat heart failure using a protein called cardiotrophin 1 (CT1). Heart failure is a leading cause of death ... |
The Ottawa Hospital awarded $12.7M for research, double the national CIHR success rate
January 30, 2018 - Sixteen research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded $12.7 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). This represents a success r |
How to trick your heart into thinking you exercise: cardiotrophin improves heart health and repairs damage in lab models
August 4, 2017 - Researchers have discovered that a protein called cardiotrophin 1 (CT1) can trick the heart into growing in a healthy way and pumping more blood, just as it does in response to exercise and pregnancy. They show that this good kind of heart growth i |
$270,000 grant to help researchers discover if a heart-growth protein can halt some heart disease
July 6, 2016 - Dr. Lynn Megeney, in collaboration with Dr. Duncan Stewart, has been awarded $270,000 from the Heart and Stroke Foundation of Canada to investigate how a protein can trigger beneficial growth in heart muscle. The heart can temporarily grow in siz |
Ottawa researchers identify the Mike Holmes of muscle stem cells
January 27, 2016 - Over the last several years, Dr. Lynn Megeney and his team have discovered that muscle stem cells have a strange way of giving rise to new muscle fibres. They turn on scissor-like proteins that cut up other proteins and strands of DNA. Usually this |
Major advance in understanding muscle regeneration: Caspase 3 tackles Pax7 in a cellular game of Pac-Man
October 14, 2015 - Stem cells control the growth and regeneration of skeletal muscle. In healthy muscle, stem cells can multiply or mature into new muscle fibres, but in diseases like Duchenne Muscular Dystrophy, stem cells become stuck and muscles deteriorate.
Now |
New research sheds light on abnormal heart muscle thickening and potential treatment
October 7, 2013 - While most people would consider a big heart to be a good thing, for heart disease experts, it is often a sign of serious disease. Now, Dr. Lynn Megeney of the Ottawa Hospital Research Institute and the University of Ottawa (uOttawa) has made the sur |
