Exercise Training for People with Advanced Multiple Sclerosis: A Feasibility Study to Inform Intervention Development
Co-Investigator
Principal Investigator: L. Pilutti
Other Co-Investigators: G. Bose, T. Edwards, A. Chaves, A. Fakolade
Sponsor: MS Canada: $49,986 (2025-2027)

Exercise Training in Women with Heart Disease – Brain Heart Interconnectome
Co-Investigator
Principal Investigator: JL Reed
Co-Principal Investigator: N Jaworska
Patient Partner, Co-Principal Investigator: A-M Julien
Other Co-Investigators: Paterson, J Edwards, K Rayner
Sponsor: Brain-Heart Interconnectome Exploration Program: $100,000 (2025-2027)

PREDIGT3.0 - Early Parkinson's Detection Through Multi-Modal Screening
Co-Investigator
Principal Investigator: Michael Schlossmacher
Co-Investigators: Juan Li, Jane Batten, Andrew Seely, Robert Dekemp, Douglas Manuel, Pat Evans, Anne Harley, Kevin Boczar, Jason Berard, Tim Ramsay, Joseph Saade, Julianna Tomlinson
Sponsor: Brain-Heart Interconnectome Exploration Program: $100,000 (2025-2027)

Fellowship for Optimizing Rehabilitation in Multiple Sclerosis (FOR-MS Fellowship) (July, 2025-June, 2030)
Co-Principal Investigator
Co-Principal Investigators: Dr. Lara Pilutti and Dr. Sara Tremblay
Sponsor: National MS Society (MB-2407-43610): $478,657USD (~$650,000Cdn)

Self-directed internet-based cognitive behaviour therapy with mindfulness: A self-management solution for depression in people living with multiple sclerosis (submitted)
Collaborator
Principal Investigator: Ruth Ann Marrie, Shay-Lee Bolton
Funding request submitted to National MS Society

Multisite Randomized Clinical Trial: Mindfulness-Based Intervention for Mild Traumatic Brain Injury (MBI-4-mTBI) (2025-2029)
Co-Investigator
Principal Investigator: Andree-Anne Ledoux
Co-Investigators: Zemek, R, Smith, A, Goldfield, G, Jaworska, N, Sicard, V, Osmond, M, Gray, C, Goulet, K, Reed, N, Anderson, P, Cairncross, M, Silverberg, N
Collaborators: Saab, B, Barrowman, N
Sponsor: CIHR: $1,308,150

Novel Pairing of Brain Priming and Rehabilitation to Restore Motor and Cognitive Abilities in Progressive Multiple Sclerosis (January 2024 – March 2025)
Co-Investigator
Principal Investigator: Lara Pilutti
Additional Co-Investigators: Sarah Donkers, Katherine Knox, Marcia Finlayson, Nancy Mayo, Michelle Ploughman
Sponsor: International Progressive MS Alliance: €99,635 (~$146,900 Cdn)

Neurocognitive Testing Service – BHI Transformational Research Platform (November 2023 – March 2026)
Principal Investigator
Co-Investigator: Jason Berard
Sponsor: uOttawa Brain-Heart Interconnectome (BHI) initiative through Canada First Research Excellence Fund (CFREF): $371,875

App-Based Mindfulness Training for Individuals with Multiple Sclerosis: Feasibility and Impacts on Perceived Stress
Principal Investigator
Co-Investigator: Jordan Pumphrey, Jason Berard
Sponsor: self-funded

Treating Brain-Heart Interconnectome by Prescribed Exercise Following Adult Concussion – A Randomized Control Trial (November 2023 - March 2026)
Co-Investigator
Principal Investigator: Roger Zemek & Sharon Johnston
Additional Co-Investigators: Andree-Anne Ledoux, Richard Webster, Jennifer Reed, Andra Smith, Veronik Sicard, Rebecca Robillard
Collaborators: John Leddy, Nick Reed, Kim Connelly, Rebekah Mannix, Christina Master, Steven Hicks
Patient Partner: Erin Fox
Sponsor: uOttawa Brain-Heart Interconnectome (BHI) initiative through Canada First Research Excellence Fund (CFREF): $397,601

Assessing Strategic Planning Processes When Reaching in a Novel Visuomotor Environment in People with Multiple Sclerosis
Co-Investigator
Principal Investigator: Erin Cressman
Additional Co-Investigators: Lara Pilutti
Partial funding obtained through uOBMRI TRIMS (2022) Award and endMS Studentship (2019-2023)
Student Project (Darrin Wijeyaratnam) Cognitive-motor assessment in people with multiple sclerosis

Development of a Behavioural Intervention for Cognitive Fatigability in Multiple Sclerosis (DABC-MS)
Principal Investigator
Co-Investigators: L. Pilutti, J. Berard, M. Finlayson & S. Morrow
Collaborator: M. Freedman
Internal funding

Development of a Neurocognitive Testing Service: Expanding uOBMRI Capacity for Incorporating Innovative and Cross-theme Research Using Cognitive and Patient Reported Outcomes (2022-2023)
Principal Investigator
Co-Investigators: Berard, J., Beaudry, S., Ismail, N., Smith, A., Dowlatshahi, D., Freedman, M., Warman, J., Schlossmacher, M., Marshall, S., Knoefel, F., Hsu, A.
Sponsored by the University of Ottawa Brain and Mind Research Institute and partners: $100,000

Mindfulness-Based Intervention of Mild Traumatic Brain Injury + MRI: A Pilot Study (MBI-4-mTBI) (2022-2023)
Co-Investigator
Principal Investigator: Andree-Anne Ledoux
Co-Investigators: Zemek, R, Smith, A, Goldfield, G, Jaworska, N, Sicard, V, Osmond, M, Gray, C, Goulet, K, Reed, N, Anderson, P, Cairncross, M, Silverberg, N
Collaborators: Saab, B, Barrowman, N
Sponsored by the University of Ottawa Brain and Mind Research Institute and partners: $50,000

Monoacylglycerol lipase (Mgll) expression as a biomarker to guide metformin-responsive treatment in MS patients with cognitive deficits (2021-2022)
Co-Investigator
Principal Investigator: J. Wang
Co-Investigators: M. Freedman
Sponsor: University of Ottawa Brain and Mind Research Institute – Multiple Sclerosis Research Group: $50,000

Mindfulness-Based Intervention of Mild Traumatic Brain Injury with MRI (MBI-4-mTBI) (2021-2022)
Co-Investigator
Principal Investigator: Andree-Anne Ledoux
Co-Investigators: Zemek, Smith, Jaworska, Osmond, Gray, Goulet, Reed, Anderson, Cairncross, Silverberg
Collaborators: Saab, Barrowman and Leeder
Sponsored by the University of Ottawa Brain and Mind Research Institute and partners: $75,000

Addressing Research-to-Practice Gaps in Multiple Sclerosis Care: Implementation of a Screening Program for Mental Health, Cognitive and Psychosocial Concerns (2019-2020)
Principal Investigator
Co-Investigators: M.S. Freedman, M. Bowman, L.Cannata, H. MacLean, C. Rush, V. Doyle, S. Hatcher
Sponsored by the University of Ottawa Brain and Mind Institute: $20,000

Characterizing the Acute Response to Adapted Exercise in Non-ambulatory People with Multiple Sclerosis (2019-2020)
Co-Investigator
Principal Investigator: Lara Pilutti
Additional Co-Investigator: Thomas Edwards
Sponsored by the National Multiple Sclerosis Society: $58,267.30

Cognitive Symptom Management and Rehabilitation Therapy for People Living with Multiple Sclerosis (CogSMART for MS) (2017-ongoing)
Principal Investigator
Co-Investigator: Mike Van Adel, Jo-Anne Lefevre
Funding from proceeds of clinical service delivery at Ricci and Associates

Functional Electrical Stimulation Cycling for Managing Mobility Disability in People with Multiple Sclerosis (2018-2020)
Collaborator
Principal Investigator: Lara Pilutti
Additional Collaborator: Mark Freedman
Sponsored by MS Society of Canada: $294,450

Mesenchymal Stem Cell Therapy for Canadian MS Patients (MESCAMS) (2014-2019)
Co- Investigator
Principal Investigator: Mark Freedman, M.D.; Winnipeg site PI: James Marriott
Co-Investigators: David Courtman, Heather MacLean, Carolina Rush, Mohammad Abdoli, Roxana Cruce, Harold Atkins, David Allan, Carlos Torres, Santanu Chakraborty, Fiona Costello, Francois Tremblay, Daniel Lelli, Ruth Ann Marrie, David Szwajcer, Donna Wall.
Sponsored by the Research Foundation of the Multiple Sclerosis Society of Canada: $4.2 million

Using Computers to Assess Cognition in MS: Improving tried and tested indices to capture real world challenges (SUNSCREEN-m) (2014-2016)
Co-Principal Investigator
Co-Principal Investigator: Anthony Feinstein, M.D., Ph.D. (Sunnybrook Health Sciences Centre)
Sponsored by the Multiple Sclerosis Society of Canada: $185,294

Ottawa Mindfulness in Multiple Sclerosis – Pilot Study (OMIMS Pilot) (2014)
Co-Principal Investigator
Co-Principal Investigator: Heather MacLean, M.D.; Co-Investigators: Andra Smith, Ph.D., Patricia Poulin, Ph.D.
Self-funded

Default Network as a Marker of Cognitive Fatigue in Multiple Sclerosis (DefNeMS) (2013-2018)
Co-investigator
Principle Investigator: Mark Freedman, M.D.
Additional Co-Investigators: Andra Smith, Ph.D., Roxana Cruce, M.D., Ian Cameron, M.D., Greg Cron, Ph.D., Santanu Chakraborty, M.D.
Sponsored by surplus funds: $66,820

Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS): Canadian contribution to the international validation project. (2013-2015)
Principal Investigator
Co-investigators: Laura Rees, Ph.D., Mark Freedman, M.D., Denis Cousineau, Ph.D., Heather MacLean, M.D.
Sponsored by University of Ottawa Brain and Mind Research Institute: $40,000

Cognition and Neuroimaging in CIS: Effect of Interferon in Very Early MS (CONCEIVE). (2010-2013)
Co-investigator
Principal Investigator: Mark Freedman, M.D.; Co-investigator: Andra Smith, Ph.D., Santanu Chakraborty, M.D.
Sponsored by Bayer HealthCare: Pharmaceuticals Division: $329,838

A New Clinical Test for Measuring Information Processing in MS Patients: The Computerized Tests of Information Processing (CTIP) (IPSIMS). (2008-2011)
Principal Investigator
Co-investigators: Laura Rees, Ph.D., Mark Freedman, M.D.
Sponsored by the Multiple Sclerosis Society of Canada: $69,289

Long Term Outcomes Following Immunoablative Therapy and Autologous Stem Cell Transplant for Poor Prognosis Multiple Sclerosis. (2007-2012)
Co-investigator
Principal Investigators: Harold Atkins, M.D., Mark Freedman, M.D.
Sponsored by the MS Society Scientific Research Foundation: $2,419,701

High Dose Chemotherapy Induced Changes in the Brain of Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT). (2008-indefinite)
Co-investigator
Principal Investigators: Harold Atkins, M.D., Mark Freedman, M.D.
Additional Co-investigators: David Allan, M.D., Doug Arnold, M.D., Isabelle Bence-Bruckler, M.D., Jacqueline Chen, Ph.D., Lothar Huebsch, M.D., Mitchell Sabloff, M.D.
Sponsored by the MS Society Scientific Research Foundation: $48,866.20

Granulocyte-Colony Stimulating Factor in Ischemic Stroke Trial (GIST). A Pilot Study. (2006-2012)
Co-investigator
Principal investigator: Harold Atkins, M.D.
Sponsored by the Heart and Stroke Foundation Centre for Stroke Recovery $75,000

Description and course of cognitive dysfunction in patients with multiple sclerosis who lack neurological disability. A pilot study on neuropsychological evaluation and MRI abnormalities (CAIMS). (2004-2006)
Co-investigator
Principal investigator: Mark Freedman, M.D.
Sponsored by Serono Canada, Inc. $102,063

Detecting Cognitive Impairments Using the Computerized Tests of Information Processing (2005-2006)
Co-investigator
Principal Investigator: Tom Tombaugh, Ph.D.
Sponsored by the Multiple Sclerosis Society of Canada $13,600

Neuropsychological Database for Patients with Multiple Sclerosis. (terminated 2008)
Principal investigator

Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ) for use in detecting cognitive impairment. (terminated 2008)
Co-investigator
Principal investigator: Paul Mendella, Ph.D.

Secondary Prevention of Small Subcortical Stroke (SPS3). (terminated)
Neuropsychology Consultant
Principal investigator at TOH: Dr. Michael Sharma
NIH funded