Publications
Selected Publications
Berard, J.A. & Walker, L.A.S. (2022). Validity and sensitivity of Canadian normative data for the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery. Multiple Sclerosis and Related Disorders. (published on-line 10 May 2022). https://doi.org/10.1016/j.msard.2022.103865
Berard, J.A., Freedman, M.S., Marrie, R.A., Marriott, J.J., Atkins, H.L., Szwajcer, D., Courtman, D.W., Thebault, S. & Walker, L.A.S. (2022). The impact of mesenchymal stem cell therapy on cognition in individuals with multiple sclerosis. Multiple Sclerosis and Related Disorders, 61, 1-8, 103779 (published on-line 27 March 2022). https://doi.org/10.1016/j.msard.2022.103779
Berard, J.A. & Walker, L.A.S. (2021). Increasing the clinical utility of the Paced Auditory Serial Addition Test: Normative data for standard performance, dyad and cognitive fatigability scoring. Cognitive and Behavioral Neurology, 34(2), 107-116. https://doi:10.1097/WNN.0000000000000268. PMID: 34074865
Walker, L.A.S., Lindsay-Brown, A.P. & Berard, J.A. (2019). Cognitive fatigability interventions in neurological conditions: A systematic review. Neurology and Therapy, 8(2), 251-271. (published on-line 4 October 2019). http://link.springer.com/article/10.1007/s40120-019-00158-3. PMID: 31586303
Atkins, H.L., Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar-Or, A., Bence-Bruckler, I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin, L., Heubsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin, L., McDiarmid, S., O’Connor, P., Ramsay, T., Sabloff, M., Walker, L.A.S. & Freedman, M.S. (2016; 6-12 Aug). Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet, 388 (10044), 576-585, (online 9 June 2016) http://dx.doi.org/10.1016/S0140-6736(16)30169-6 PMID: 27291994
All Other Publications
1. Hamwi, M.*, Thebault, S.*, Melkus, G., Auriat, A., Pham, A., Carrington, A., Thornhill, R., Walker, L.A.S., Chakraborty, S., Torres, C., Zhang, L., Atkins, H., Freedman, M. & Aviv, R. (2023). MRI graph parameters are longitudinal markers of neuronal integrity in multiple sclerosis. Multiple Sclerosis and Related Disorders. (published on-line 11 October 2023) (* denotes co-first authors) https://doi.org/10.1016/j.msard.2023.105066
2. Walker, L.A.S., Berard, J.A., Islam, T., Pilutti, L.A., Morrow, S.A. & Finlayson, M. (2022). Development of a behavioural intervention for cognitive fatigability in multiple sclerosis: Protocol for a pilot and feasibility study. Frontiers in Rehabilitation Sciences, 3:999266. (published on-line 16 November 2022). https://www.frontiersin.org/articles/10.3389/fresc.2022.999266/full
3. MacAdam, E., Berard, J.A. & Walker, L.A.S. (2022). Cognition and cognitive fatigability: Predicting employment status in multiple sclerosis. Canadian Journal of Neurological Sciences, 1-6. https://doi.org/10.1017/cjn.2022.309
4. Berrigan, L.I., LeFevre, J., Rees, L.M., Berard, J.A., Francis, A., Freedman, M.S. & Walker, L.A.S. (2022). The Symbol Digit Modalities Test and the Paced Auditory Serial Addition Test involve more than processing speed for persons with multiple sclerosis and controls. Multiple Sclerosis and Related Disorders, 104229, 1-6. (published on-line 7 October 2022). https://doi.org/10.1016/j.msard.2022.104229.
5. Berard, J.A. & Walker,
L.A.S. (2022). Validity and sensitivity of Canadian normative data for the Minimal Assessment of
Cognitive Function in Multiple Sclerosis (MACFIMS) battery. Multiple Sclerosis and Related
Disorders. (published on-line 10 May 2022). https://doi.org/10.1016/j.msard.2022.103865
6. Berard, J.A., Freedman, M.S.,
Marrie, R.A., Marriott, J.J., Atkins, H.L., Szwajcer, D., Courtman, D.W.,
Thebault, S. & Walker, L.A.S. (2022). The impact of mesenchymal stem cell therapy
on cognition in individuals with multiple sclerosis. Multiple Sclerosis and Related
Disorders, 61, 1-8, 103779 (published on-line 27 March 2022). https://doi.org/10.1016/j.msard.2022.103779
7. Walker, C. S., Berard,
J.A. & Walker, L.A.S. (2021).
Validation of discrete and regression-based performance and cognitive
fatigability normative data for the Paced Auditory Serial Addition Test in
multiple sclerosis. Frontiers in
Neuroscience, 15:730817. (published on-line 15 November 2021). https://doi.org/10.3389/fnins.2021.730817.
8. Agyemang, C., Berard, J.A. & Walker, L.A.S. (2021). Cognitive fatigability in multiple sclerosis:
How does performance decline over time on the Paced Auditory Serial Addition
Test? Multiple Sclerosis and Related Disorders, 54: 103130. (published on-line
10 July 2021). https://doi.org/10.1016/j.msard.2021.103130 PMID: 34273611
9. Berard, J.A. & Walker, L.A.S. (2021). Increasing
the clinical utility of the Paced Auditory Serial Addition Test: Normative
data for standard performance, dyad and cognitive fatigability
scoring. Cognitive and Behavioral Neurology, 34(2), 107-116. https://doi:10.1097/WNN.0000000000000268. PMID: 34074865
10. Ramani, S., Berard, J.A. &
Walker, L.A.S. (2020). The
relationship between neurofilament light chains and cognition in neurological
disorders: A scoping review. Journal of the Neurological Sciences.
(published on-line 24 November 2020).
https://doi:10.1016/j.jns.2020.117229
. PMID: 33243431
11. Thebault, S., Lee, H., Bose,
G., Tessier, D., Abdoli, M., Bowman, M., Berard, J.A. Walker, L.A.S., Rush, C., MacLean, H., Booth, R. Narayanan, S.,
Arnold, D., Tabard-Cossa, V., Atkins, H., Bar-Or, A. & Freedman, M.S. (2020).
Neurotoxicity after haematopoietic
stem cell transplant for multiple sclerosis. Annals
of Clinical and Translational Neurology. (published on-line 18 April
2020). https://doi: 10.1002/acn3.51045. PMID: 32304358
12. Berard, J.A., Fang, Z., Walker, L.A.S., Lindsay-Brown, A.,
Osman, L., Cameron, I., Cruce, R., Cron, G.O., Freedman, M.S. & Smith,
A.M. (2020). Imaging cognitive fatigue
in multiple sclerosis: Objective quantification of cerebral blood flow
during a task of sustained attention using ASL perfusion fMRI. Brain
Imaging and Behavior, 14, 2417–2428 (published on-line 29 August 2019). doi: 10.1007/s11682-019-00192-7. PMID:
31468375.
13. Walker, L.A.S., Lindsay-Brown, A.P. & Berard, J.A.
(2019). Cognitive fatigability
interventions in neurological conditions: A systematic review. Neurology
and Therapy, 8(2), 251-271. (published on-line 4 October 2019). http://link.springer.com/article/10.1007/s40120-019-00158-3.
PMID: 31586303
14. Berard, J.A., Smith, A.M.
& Walker, L.A.S. (2019). Predictive models of cognitive fatigue
in multiple sclerosis. Archives of Clinical Neuropsychology,
34 (1), 31-38. (published on-line 17 February 2018). https://doi.org/10.1093/arclin/acy014.
PMID: 29471423
15. Walker, L.A.S., Gardner, C., Freedman, M.S., MacLean, H., Rush,
C. & Bowman, M. (2019).
Research-to-practice gaps in multiple sclerosis care in one Canadian
centre for those with subjective cognitive, mental health and psychosocial
concerns. International Journal of MS Care, 21, 243-248. (published on-line
Dec. 4, 2018). https://doi.org/10.7224/1537-2073.2017-090. PMID: 31889928
16. Darlington, P.J., Stopnicki,
B., Touil, T., Doucet, J-S., Fawaz, L., Roberts, M.E., Boivin, M-N., Arbour,
N., Freedman, M.S., Atkins, H.L., Bar-Or, A. for the Canadian MS/BMT Study
Group (L.Walker - member of study group) (2018). Natural killer cells regulate Th17 cells
after autologous hematopoietic stem cell transplantation for relapsing remitting
multiple sclerosis. Frontiers in
Immunology, 9, article 834.
(published on-line 07 May 2018). Doi: 10.3389/fimmu.2018.00834. PMID: 29867923
17. Barbu, R.M., Berard, J.A.,
Gresham, L.M. & Walker, L.A.S.
(2018). Longitudinal stability of
cognition in early phase relapsing-remitting multiple sclerosis: Does cognitive
reserve play a role? International Journal of MS Care,
20(4): 173-179 (published on-line Sept 11, 2017). https://doi.org/10.7224/1537-2073.2016-073.
PMID: 30150901
18. Mioduszewski. O., MacLean,
H., Poulin, P.A., Smith, A.M. & Walker,
L.A.S. (2018). Trait mindfulness
and wellness in multiple sclerosis.
Canadian Journal of Neurological
Sciences, 45(5), 580-582. (published on-line 12 July 2018). https://doi.org/10.1017/cjn.2018.51.
PMID: 30234464
19. Patel,
V.P., Walker, L.A.S. & Feinstein,
A. (2018). Revisiting cognitive
reserve and cognition in multiple sclerosis: a closer look at the role of depression. Multiple
Sclerosis Journal, 24(2), 186-195 (published on-line 13 February 2017).
http://journals.sagepub.com/doi/pdf/10.1177/1352458517692887 PMID: 28273771
20. Berard, J.A., Smith, A.M.
& Walker, L.A.S. (2018). A longitudinal evaluation of cognitive
fatigue in multiple sclerosis using the Paced Auditory Serial Addition Test
(PASAT). International Journal of MS Care, 20, 55-61 (first published
on-line Jul 13, 2017). https://doi.org/10.7224/1537-2073.2016-106. PMID: 29670491
21. Walker, L.A.S., Marino, D., Berard,
J.A., Feinstein, A., Morrow, S.A., Cousineau, D. (2017). Canadian normative data for Minimal Assessment
of Cognitive Function in Multiple Sclerosis. Canadian
Journal of Neurological Sciences, 44, 547-555 (first published on-line
Jul 7, 2017). https://doi.org/10.1017/cjn.2017.199 PMID: 28683843 (Corrigendum – Canadian Journal of Neurological Sciences, 45(5), 604. https://doi.org/10.1017/cjn.2018.308)
22. Patel, V.P., Walker, L.A.S. & Feinstein, A.
(2017). Deconstructing the Symbol Digit
Modalities Test in multiple sclerosis: The role of memory. Multiple
Sclerosis and Related Disorders, 17, 184-189. http://dx.doi.org/10.1016/j.msard.2017.08.006.
PMID: 29055455
23. Walker, L.A.S., Bourque, P., Smith, A.M. & Warman Chardon,
J. (2017). Autosomal dominant cerebellar
ataxia, deafness and narcolepsy (ADCA-DN) associated with progressive
cognitive and behavioral deterioration.
Neuropsychology, 31(3), 292-303
(first published on-line Nov 21, 2016). http://dx.doi.org/10.1037/neu0000322.
PMID: 27869457
24. Patel, V.P., Walker, L.A.S. & Feinstein, A.
(2017). Processing speed and distractibility
in multiple sclerosis: the role of sleep.
Multiple Sclerosis and Related
Disorders, 11, 40-42. http://dx.doi.org/10.1016/j.msard.2016.11.012
PMID: 28104254
25. Stamenova,
V., Jennings, J.M., Cook, S.P., Gao, F. Walker, L.A.S., Smith, A.M., Davidson, P.S.R. (2017). Repetition-Lag Memory Training is
Feasible in Patients with Chronic Stroke Patients, Including Those with Memory
Problems. Brain Injury, 31(1),
57-67. (on-line 23 November 2016). http://www.tandfonline.com/doi/full/10.1080/02699052.2016.1222081 PMID: 27880059
26. Patel, V.P., Zambrana, A.,
Walker, L.A.S., Herrmann, H. &
Feinstein, A. (2017). Distraction
adds to the cognitive burden in multiple sclerosis. Multiple
Sclerosis Journal, 23(1), 106-113.
(online 24 March 2016) DOI:
10.1177/1352458516641208 PMID: 27012660
27. Atkins, H.L.,
Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar-Or, A., Bence-Bruckler,
I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin,
L., Heubsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin,
L., McDiarmid, S., O’Connor, P., Ramsay, T., Sabloff, M., Walker, L.A.S. & Freedman, M.S.
(2016; 6-12 Aug). Immunoablation
and autologous haemopoietic stem-cell transplantation for aggressive
multiple sclerosis: a multicentre single-group phase 2 trial. The
Lancet, 388 (10044), 576-585, (online 9 June 2016) http://dx.doi.org/10.1016/S0140-6736(16)30169-6 PMID: 27291994
28. Walker, L.A.S., Berard, J.A., Bowman, M., Atkins, H.L., Lee, H., Arnold,
D. & Freedman, M.S. (2016). Longitudinal change in PASAT performance
following immunoablative therapy and haematopoietic stem cell transplant
in multiple sclerosis. Multiple Sclerosis and Demyelinating
Disorders, 1:12, DOI:10.1186/s40893-016-0014-y
29. Patel, V.P., Zambrana, A.,
Walker, L.A.S., Herrmann, N., Swartz,
R. & Feinstein, A. (2016). Distractibility
in multiple sclerosis: the role of depression. Multiple
Sclerosis Journal: Experimental, Translational and Clinical, 2, 1-5. DOI: 10.1177/2055217316653150 PMID: 28607730
30. Walker, L.A.S., Osman, L., Berard, J.A., Rees, L.M, Freedman,
M.S., MacLean, H. & Cousineau, D. (2016). Brief International Cognitive Assessment
for MS (BICAMS): Canadian contribution to the international validation project.
Journal
of the Neurological Sciences, 362, 147-152. doi:10.1016/j.jns.2016.01.040 PMID: 26944137
31. Stamenova, V., Jennings, J.M.,
Cook, S.P., Walker, L.A.S., Smith,
A.M. & Davidson, P.S.R. (2014).
Training Recollection in Healthy Older Adults: Clear Improvements on
the Training Task, but Little Evidence of Transfer. Frontiers
in Psychology, 8, 1-13. doi:
10.3389/fnhum.2014.00898 PMID: 25477801
(Corrigendum doi:10.3389/fnhum.2015.00658
PMID: 26648862)
32. Berard, J.A., Walker, L.A.S., Smith, A.M. &
Freedman, M.S. (2014). Longitudinal
comparison of desktop and fMRI scanner versions of the Computerized Test
of Information Processing in Multiple Sclerosis: A pilot study. Journal
of Multiple Sclerosis, 2(2). http://dx.doi.org/10.4172/jmso.1000121
33. Berrigan, L.I.,
Fisk, J.D., Walker, L.A.S., Wojtowicz,
M., Rees, L.M., Freedman, M.S. & Marrie, R-A. (2014). Reliability
of Regression-Based Normative Data for the Oral Symbol Digit Modalities
Test: An Evaluation of Demographic Influences, Construct Validity,
and Impairment Classification Rates
in Multiple Sclerosis Samples. The
Clinical Neuropsychologist, 28(2), 281-99. http://dx.doi.org/10.1080/13854046.2013.871337 PMID: 24438521
34. Berard, J.A., Bowman, M.,
Atkins, H.L., Freedman, M.S. & Walker,
L.A.S. (2014). Cognitive fatigue in individuals with multiple
sclerosis undergoing immunoablative therapy and haematopoietic stem cell
transplantation. Journal of the
Neurological Sciences, 336, 132-137. http://dx.doi.org/10.1016/j.jns.2013.10.023 PMID: 24189209
35. Walker, L.A.S., Berard, J.A., Atkins, H.L., Bowman, M., Lee,
H. & Freedman, M.S. (2014). Cognitive change and neuroimaging following
immunoablative therapy and hematopoietic stem cell transplantation in multiple
sclerosis: A pilot study. Multiple Sclerosis and Related Disorders,
3, 129-135. http://dx.doi.org/10.1016/j.msard.2013.05.001
PMID: 25877984
36. Berrigan, L.I., LeFevre, J.,
Rees, L.M., Walker, L.A.S.,
Berard, J. & Freedman, M.S. (2013).
Cognition in early relapsing-remitting
multiple sclerosis: Consequences may be relative to working memory. Journal
of the International Neuropsychological Society, 19(8), 938-949.
http://dx.doi.org/10.1017/S1355617713000696 PMID: 23866100
37. Walker, L.A.S., Berard, J., Berrigan, L.I.,
Rees, L.M. & Freedman, M.S. (2012). Detecting cognitive fatigue in
multiple sclerosis: Method matters. Journal
of the Neurological Sciences, 316, 86-92. doi:10.1016/j.jns.2012.01.021.
PMID: 22336698
38. Walker, L.A.S., Cheng, A., Berard, J.,
Berrigan, L.I., Rees, L.M. & Freedman, M.S. (2012). Tests of information processing speed:
What do people with multiple sclerosis think about them? International
Journal of MS Care, 14, 92-99. (article
won Herndon Award for Outstanding
International Journal of MS Care Article for best article published in
2012) doi: 10.7224/1537-2073-14.2.92. PMID: 24453739
39. Smith, A.M., Walker, L.A.S., Freedman, M.S.,
Berrigan, L.I., St. Pierre, J., Hogan, M. & Cameron, I. (2012). Activation Patterns in Multiple Sclerosis on the Computerized Tests
of Information Processing: Speed and Task Matter. Journal
of the Neurological Sciences, 312, 131-137. doi: 10.1016/j.jns.2011.08.003 PMID: 21862036
40. Walker, L.A.S., Mendella, P.D., Stewart, A., Freedman, M.S.
& Smith, A.M (2011). Meaningful
change in cognition in MS: Method matters.
Canadian Journal of Neurological
Sciences, 38, 282-288. DOI: 10.1017/s0317167100011471 PMID: 21320834
41. Tombaugh, T. N., Berrigan,
L. I., Walker, L.A.S. & Freedman, M. S. (2010). The Computerized Tests of Information Processing
(CTIP) Offers an Alternative to the PASAT for Assessing Cognitive Processing
Speed in Individuals with Multiple Sclerosis. Cognitive
and Behavioral Neurology, 23(3), 192-198. DOI: 10.1097/WNN.0b013e3181cc8bd4 PMID: 20829669
42. Smith, A.M., Walker, L.A.S., Freedman, M.S.,
DeMeulemeester, C., & Hogan, M. (2009). fMRI investigation of disinhibition in cognitively
impaired patients with multiple sclerosis. Journal
of the Neurological Sciences, 281, 58-63. Published on-line (doi:10.1016/j.jns.2009.02.366). PMID: 19344919
43. Walker, L. & DeMeulemeester, C. (2008). Spontaneous intracranial hypotension masquerading
as frontotemporal dementia. The Clinical Neuropsychologist, 22,
1035-1053. doi: 10.1080/13854040701874386 PMID: 18609334
44. Reicker, L. I., Tombaugh, T. N., Walker, L., Freedman, M. S. (2007).
Reaction Time: An alternative method
for assessing the effects of multiple sclerosis on information
processing speed. Archives of Clinical Neuropsychology, 22, 655-664. https://doi.org/10.1016/j.acn.2007.04.008 PMID: 17532182PubMed Listings