Publications
Selected Publications
Donkers, S. J. & Walker, L.A.S. (2025). An interdisciplinary approach is necessary in the treatment of cognitive decline in MS – Yes. Multiple Sclerosis Journal, 31(3): 257-259. https://doi.org/10.1177/13524585251315344
Walker, L.A.S., Berard, J.A., Islam, T., Pilutti, L.A., Morrow, S.A. & Finlayson, M. (2022). Development of a behavioural intervention for cognitive fatigability in multiple sclerosis: Protocol for a pilot and feasibility study. Frontiers in Rehabilitation Sciences, 3:999266. (published on-line 16 November 2022). https://www.frontiersin.org/articles/10.3389/fresc.2022.999266/full
Berard, J.A. & Walker, L.A.S. (2022). Validity and Sensitivity of Canadian Normative Data for the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) Battery. Multiple Sclerosis and Related Disorders, 63, 103865. (published on-line 10 May 2022). https://doi.org/10.1016/j.msard.2022.103865
Berard, J.A., Freedman, M.S., Marrie, R.A., Marriott, J.J., Atkins, H.L., Szwajcer, D., Courtman, D.W., Thebault, S. & Walker, L.A.S. (2022). The impact of mesenchymal stem cell therapy on cognition in individuals with multiple sclerosis. Multiple Sclerosis and Related Disorders, 61, 1-8, 103779 (published on-line 27 March 2022). https://doi.org/10.1016/j.msard.2022.103779
Berard, J.A. & Walker, L.A.S. (2021). Increasing the clinical utility of the Paced Auditory Serial Addition Test: Normative data for standard performance, dyad and cognitive fatigability scoring. Cognitive and Behavioral Neurology, 34(2), 107-116. https://doi:10.1097/WNN.0000000000000268. PMID: 34074865
Atkins, H.L., Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar-Or, A., Bence-Bruckler, I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin, L., Heubsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin, L., McDiarmid, S., O’Connor, P., Ramsay, T., Sabloff, M., Walker, L.A.S. & Freedman, M.S. (2016; 6-12 Aug). Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet, 388 (10044), 576-585, (online 9 June 2016) http://dx.doi.org/10.1016/S0140-6736(16)30169-6 PMID: 27291994
All Other Publications
1. Edwards T, Chaves AR, Awadia Z, Ludgate J, Peters A, Walker LAS, Pilutti LA. (accepted). Feasibility of Aerobic Exercise in People with Advanced Multiple Sclerosis: Characterizing Acute Responses to Inform Exercise Prescription. International Journal of Multiple Sclerosis Care.
2. Islam, T., Pumphrey, J.D., Bowman, M., Berard, J.A., Bearnes, R., Pham, T. & Walker, L.A.S. (accepted). Implementation of Cognition, Fatigue, and Mental Health Screening at a Canadian Multiple Sclerosis Centre: A Quality Improvement Initiative. International Journal of Multiple Sclerosis Care.
3. Donkers, S. J. & Walker, L.A.S. (2025). An interdisciplinary approach is necessary in the treatment of cognitive decline in MS – Yes. Multiple Sclerosis Journal, 31(3): 257-259. https://doi.org/10.1177/13524585251315344
4. Chaves, A.R., Edwards, T., Awadia, Z., Morin, V., Walker, L.A.S., Reed, J.L. & Pilutti, L.A. (2024). Physiological fitness in people with advanced multiple sclerosis. Multiple Sclerosis and Related Disorders, 91, 105854. https://www.msard-journal.com/article/S2211-0348(24)00431-0/fulltext
5. Pumphrey, J.D., Ramani, S., Islam, T., Berard, J.A., Seegobin, M., Lymer, J.M., Freedman, M.S., Wang, J. & Walker, L.A.S. (2024). Assessing multimodal emotion recognition in multiple sclerosis with a clinically accessible measure. Multiple Sclerosis and Related Disorders, 86, 105603. https://doi.org/10.1016/j.msard.2024.105603
6. Ledoux, A-A., Zemek, R., Cairncross, M., Silverberg, N.D., Sicard, V., Barrowman, N., Goldfield, G., Gray, C., Harris, A.D., Jaworska, N., Reed, N., Saab, B., Smith, A. & Walker, L.A.S. (2024). Smartphone-App delivered Mindfulness-Based Intervention for Mild Traumatic Brain Injury (MBI-4-mTBI): A Feasibility Randomized Control Trial in Adolescents. Journal of Medical Internet Research, 13, e57226. https://www.researchprotocols.org/2024/1/e57226/
7. Fabiano, N., Dholakia, S., Walker, L. & Smith, A. (2024). Chronic dimenhydrinate use contributing to early multifactorial cognitive impairment. BMJ Case Reports, 17, e258493. DOI: 10.1136/bcr-2023-258493. https://casereports.bmj.com/content/17/3/e258493
8. Hamwi, M.*, Thebault, S.*, Melkus, G., Auriat, A., Pham, A., Carrington, A., Thornhill, R., Walker, L.A.S., Chakraborty, S., Torres, C., Zhang, L., Atkins, H., Freedman, M. & Aviv, R. (2023). MRI graph parameters are longitudinal markers of neuronal integrity in multiple sclerosis. Multiple Sclerosis and Related Disorders, 80, 105066. (published on-line 11 October 2023) (* denotes co-first authors) https://doi.org/10.1016/j.msard.2023.105066
9. Walker, L.A.S., Berard, J.A., Islam, T., Pilutti, L.A., Morrow, S.A. & Finlayson, M. (2022). Development of a behavioural intervention for cognitive fatigability in multiple sclerosis: Protocol for a pilot and feasibility study. Frontiers in Rehabilitation Sciences, 3:999266. (published on-line 16 November 2022). https://www.frontiersin.org/articles/10.3389/fresc.2022.999266/full
10. MacAdam, E., Berard, J.A. & Walker, L.A.S. (2022). Cognition and cognitive fatigability: Predicting employment status in multiple sclerosis. Canadian Journal of Neurological Sciences, 50(6), 1-6. https://doi.org/10.1017/cjn.2022.309
11. Berrigan, L.I., LeFevre, J., Rees, L.M., Berard, J.A., Francis, A., Freedman, M.S. & Walker, L.A.S. (2022). The Symbol Digit Modalities Test and the Paced Auditory Serial Addition Test involve more than processing speed for persons with multiple sclerosis and controls. Multiple Sclerosis and Related Disorders, 68, 1-6, 104229. (published on-line 7 October 2022). https://doi.org/10.1016/j.msard.2022.104229.
12. Berard, J.A. & Walker, L.A.S. (2022). Validity and Sensitivity of Canadian Normative Data for the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) Battery. Multiple Sclerosis and Related Disorders, 63, 103865. (published on-line 10 May 2022). https://doi.org/10.1016/j.msard.2022.103865
13. Berard, J.A., Freedman, M.S., Marrie, R.A., Marriott, J.J., Atkins, H.L., Szwajcer, D., Courtman, D.W., Thebault, S. & Walker, L.A.S. (2022). The impact of mesenchymal stem cell therapy on cognition in individuals with multiple sclerosis. Multiple Sclerosis and Related Disorders, 61, 1-8, 103779 (published on-line 27 March 2022). https://doi.org/10.1016/j.msard.2022.103779
14. Walker, C. S., Berard, J.A. & Walker, L.A.S. (2021). Validation of discrete and regression-based performance and cognitive fatigability normative data for the Paced Auditory Serial Addition Test in multiple sclerosis. Frontiers in Neuroscience, 15:730817. (published on-line 15 November 2021). https://doi.org/10.3389/fnins.2021.730817.
15. Agyemang, C., Berard, J.A. & Walker, L.A.S. (2021). Cognitive fatigability in multiple sclerosis: How does performance decline over time on the Paced Auditory Serial Addition Test? Multiple Sclerosis and Related Disorders, 54: 103130. (published on-line 10 July 2021). https://doi.org/10.1016/j.msard.2021.103130 PMID: 34273611
16. Berard, J.A. & Walker, L.A.S. (2021). Increasing the clinical utility of the Paced Auditory Serial Addition Test: Normative data for standard performance, dyad and cognitive fatigability scoring. Cognitive and Behavioral Neurology, 34(2), 107-116. https://doi:10.1097/WNN.0000000000000268. PMID: 34074865
17. Ramani, S., Berard, J.A. & Walker, L.A.S. (2021). The relationship between neurofilament light chains and cognition in neurological disorders: A scoping review. Journal of the Neurological Sciences. 420, 117229 (published on-line 24 November 2020). https://doi:10.1016/j.jns.2020.117229 . PMID: 33243431
18. Thebault, S., Lee, H., Bose, G., Tessier, D., Abdoli, M., Bowman, M., Berard, J.A. Walker, L.A.S., Rush, C., MacLean, H., Booth, R. Narayanan, S., Arnold, D., Tabard-Cossa, V., Atkins, H., Bar-Or, A. & Freedman, M.S. (2020). Neurotoxicity after haematopoietic stem cell transplant for multiple sclerosis. Annals of Clinical and Translational Neurology. (published on-line 18 April 2020). https://doi: 10.1002/acn3.51045. PMID: 32304358
19. Berard, J.A., Fang, Z., Walker, L.A.S., Lindsay-Brown, A., Osman, L., Cameron, I., Cruce, R., Cron, G.O., Freedman, M.S. & Smith, A.M. (2020). Imaging cognitive fatigue in multiple sclerosis: Objective quantification of cerebral blood flow during a task of sustained attention using ASL perfusion fMRI. Brain Imaging and Behavior, 14, 2417–2428 (published on-line 29 August 2019). doi: 10.1007/s11682-019-00192-7. PMID: 31468375.
20. Walker, L.A.S., Lindsay-Brown, A.P. & Berard, J.A. (2019). Cognitive fatigability interventions in neurological conditions: A systematic review. Neurology and Therapy, 8(2), 251-271. (published on-line 4 October 2019). http://link.springer.com/article/10.1007/s40120-019-00158-3. PMID: 31586303
21. Berard, J.A., Smith, A.M. & Walker, L.A.S. (2019). Predictive models of cognitive fatigue in multiple sclerosis. Archives of Clinical Neuropsychology, 34 (1), 31-38. (published on-line 17 February 2018). https://doi.org/10.1093/arclin/acy014. PMID: 29471423
22. Walker, L.A.S., Gardner, C., Freedman, M.S., MacLean, H., Rush, C. & Bowman, M. (2019). Research-to-practice gaps in multiple sclerosis care in one Canadian centre for those with subjective cognitive, mental health and psychosocial concerns. International Journal of MS Care, 21, 243-248. (published on-line Dec. 4, 2018). https://doi.org/10.7224/1537-2073.2017-090. PMID: 31889928
23. Darlington, P.J., Stopnicki, B., Touil, T., Doucet, J-S., Fawaz, L., Roberts, M.E., Boivin, M-N., Arbour, N., Freedman, M.S., Atkins, H.L., Bar-Or, A. for the Canadian MS/BMT Study Group (L.Walker - member of study group) (2018). Natural killer cells regulate Th17 cells after autologous hematopoietic stem cell transplantation for relapsing remitting multiple sclerosis. Frontiers in Immunology, 9, article 834. (published on-line 07 May 2018). Doi: 10.3389/fimmu.2018.00834. PMID: 29867923
24. Barbu, R.M., Berard, J.A., Gresham, L.M. & Walker, L.A.S. (2018). Longitudinal stability of cognition in early phase relapsing-remitting multiple sclerosis: Does cognitive reserve play a role? International Journal of MS Care, 20(4): 173-179 (published on-line Sept 11, 2017). https://doi.org/10.7224/1537-2073.2016-073. PMID: 30150901
25. Mioduszewski. O., MacLean, H., Poulin, P.A., Smith, A.M. & Walker, L.A.S. (2018). Trait mindfulness and wellness in multiple sclerosis. Canadian Journal of Neurological Sciences, 45(5), 580-582. (published on-line 12 July 2018). https://doi.org/10.1017/cjn.2018.51. PMID: 30234464
26. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2018). Revisiting cognitive reserve and cognition in multiple sclerosis: a closer look at the role of depression. Multiple Sclerosis Journal, 24(2), 186-195 (published on-line 13 February 2017). http://journals.sagepub.com/doi/pdf/10.1177/1352458517692887 PMID: 28273771
27. Berard, J.A., Smith, A.M. & Walker, L.A.S. (2018). A longitudinal evaluation of cognitive fatigue in multiple sclerosis using the Paced Auditory Serial Addition Test (PASAT). International Journal of MS Care, 20, 55-61 (first published on-line Jul 13, 2017). https://doi.org/10.7224/1537-2073.2016-106. PMID: 29670491
28. Walker, L.A.S., Marino, D., Berard, J.A., Feinstein, A., Morrow, S.A., Cousineau, D. (2017). Canadian normative data for Minimal Assessment of Cognitive Function in Multiple Sclerosis. Canadian Journal of Neurological Sciences, 44, 547-555 (first published on-line Jul 7, 2017). https://doi.org/10.1017/cjn.2017.199 PMID: 28683843 (Corrigendum – Canadian Journal of Neurological Sciences, 45(5), 604. https://doi.org/10.1017/cjn.2018.308)
29. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2017). Deconstructing the Symbol Digit Modalities Test in multiple sclerosis: The role of memory. Multiple Sclerosis and Related Disorders, 17, 184-189. http://dx.doi.org/10.1016/j.msard.2017.08.006. PMID: 29055455
30. Walker, L.A.S., Bourque, P., Smith, A.M. & Warman Chardon, J. (2017). Autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration. Neuropsychology, 31(3), 292-303 (first published on-line Nov 21, 2016). http://dx.doi.org/10.1037/neu0000322. PMID: 27869457
31. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2017). Processing speed and distractibility in multiple sclerosis: the role of sleep. Multiple Sclerosis and Related Disorders, 11, 40-42. http://dx.doi.org/10.1016/j.msard.2016.11.012 PMID: 28104254
32. Stamenova, V., Jennings, J.M., Cook, S.P., Gao, F. Walker, L.A.S., Smith, A.M., Davidson, P.S.R. (2017). Repetition-Lag Memory Training is Feasible in Patients with Chronic Stroke Patients, Including Those with Memory Problems. Brain Injury, 31(1), 57-67. (on-line 23 November 2016). http://www.tandfonline.com/doi/full/10.1080/02699052.2016.1222081 PMID: 27880059
33. Patel, V.P., Zambrana, A., Walker, L.A.S., Herrmann, H. & Feinstein, A. (2017). Distraction adds to the cognitive burden in multiple sclerosis. Multiple Sclerosis Journal, 23(1), 106-113. (online 24 March 2016) DOI: 10.1177/1352458516641208 PMID: 27012660
34. Atkins, H.L., Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar-Or, A., Bence-Bruckler, I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin, L., Heubsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin, L., McDiarmid, S., O’Connor, P., Ramsay, T., Sabloff, M., Walker, L.A.S. & Freedman, M.S. (2016; 6-12 Aug). Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet, 388 (10044), 576-585, (online 9 June 2016) http://dx.doi.org/10.1016/S0140-6736(16)30169-6 PMID: 27291994
35. Walker, L.A.S., Berard, J.A., Bowman, M., Atkins, H.L., Lee, H., Arnold, D. & Freedman, M.S. (2016). Longitudinal change in PASAT performance following immunoablative therapy and haematopoietic stem cell transplant in multiple sclerosis. Multiple Sclerosis and Demyelinating Disorders, 1:12, DOI:10.1186/s40893-016-0014-y
36. Patel, V.P., Zambrana, A., Walker, L.A.S., Herrmann, N., Swartz, R. & Feinstein, A. (2016). Distractibility in multiple sclerosis: the role of depression. Multiple Sclerosis Journal: Experimental, Translational and Clinical, 2, 1-5. DOI: 10.1177/2055217316653150 PMID: 28607730
37. Walker, L.A.S., Osman, L., Berard, J.A., Rees, L.M, Freedman, M.S., MacLean, H. & Cousineau, D. (2016). Brief International Cognitive Assessment for MS (BICAMS): Canadian contribution to the international validation project. Journal of the Neurological Sciences, 362, 147-152. doi:10.1016/j.jns.2016.01.040 PMID: 26944137
38. Stamenova, V., Jennings, J.M., Cook, S.P., Walker, L.A.S., Smith, A.M. & Davidson, P.S.R. (2014). Training Recollection in Healthy Older Adults: Clear Improvements on the Training Task, but Little Evidence of Transfer. Frontiers in Psychology, 8, 1-13. doi: 10.3389/fnhum.2014.00898 PMID: 25477801 (Corrigendum doi:10.3389/fnhum.2015.00658 PMID: 26648862)
39. Berard, J.A., Walker, L.A.S., Smith, A.M. & Freedman, M.S. (2014). Longitudinal comparison of desktop and fMRI scanner versions of the Computerized Test of Information Processing in Multiple Sclerosis: A pilot study. Journal of Multiple Sclerosis, 2(2). http://dx.doi.org/10.4172/jmso.1000121
40. Berrigan, L.I., Fisk, J.D., Walker, L.A.S., Wojtowicz, M., Rees, L.M., Freedman, M.S. & Marrie, R-A. (2014). Reliability of Regression-Based Normative Data for the Oral Symbol Digit Modalities Test: An Evaluation of Demographic Influences, Construct Validity, and Impairment Classification Rates in Multiple Sclerosis Samples. The Clinical Neuropsychologist, 28(2), 281-99. http://dx.doi.org/10.1080/13854046.2013.871337 PMID: 24438521
41. Berard, J.A., Bowman, M., Atkins, H.L., Freedman, M.S. & Walker, L.A.S. (2014). Cognitive fatigue in individuals with multiple sclerosis undergoing immunoablative therapy and haematopoietic stem cell transplantation. Journal of the Neurological Sciences, 336, 132-137. http://dx.doi.org/10.1016/j.jns.2013.10.023 PMID: 24189209
42. Walker, L.A.S., Berard, J.A., Atkins, H.L., Bowman, M., Lee, H. & Freedman, M.S. (2014). Cognitive change and neuroimaging following immunoablative therapy and hematopoietic stem cell transplantation in multiple sclerosis: A pilot study. Multiple Sclerosis and Related Disorders, 3, 129-135. http://dx.doi.org/10.1016/j.msard.2013.05.001 PMID: 25877984
43. Berrigan, L.I., LeFevre, J., Rees, L.M., Walker, L.A.S., Berard, J. & Freedman, M.S. (2013). Cognition in early relapsing-remitting multiple sclerosis: Consequences may be relative to working memory. Journal of the International Neuropsychological Society, 19(8), 938-949. http://dx.doi.org/10.1017/S1355617713000696 PMID: 23866100
44. Walker, L.A.S., Berard, J., Berrigan, L.I., Rees, L.M. & Freedman, M.S. (2012). Detecting cognitive fatigue in multiple sclerosis: Method matters. Journal of the Neurological Sciences, 316, 86-92. doi:10.1016/j.jns.2012.01.021. PMID: 22336698
45. Walker, L.A.S., Cheng, A., Berard, J., Berrigan, L.I., Rees, L.M. & Freedman, M.S. (2012). Tests of information processing speed: What do people with multiple sclerosis think about them? International Journal of MS Care, 14, 92-99. (article won Herndon Award for Outstanding International Journal of MS Care Article for best article published in 2012) doi: 10.7224/1537-2073-14.2.92. PMID: 24453739
46. Smith, A.M., Walker, L.A.S., Freedman, M.S., Berrigan, L.I., St. Pierre, J., Hogan, M. & Cameron, I. (2012). Activation Patterns in Multiple Sclerosis on the Computerized Tests of Information Processing: Speed and Task Matter. Journal of the Neurological Sciences, 312, 131-137. doi: 10.1016/j.jns.2011.08.003 PMID: 21862036
47. Walker, L.A.S., Mendella, P.D., Stewart, A., Freedman, M.S. & Smith, A.M (2011). Meaningful change in cognition in MS: Method matters. Canadian Journal of Neurological Sciences, 38, 282-288. DOI: 10.1017/s0317167100011471 PMID: 21320834
48. Tombaugh, T. N., Berrigan, L. I., Walker, L.A.S. & Freedman, M. S. (2010). The Computerized Tests of Information Processing (CTIP) Offers an Alternative to the PASAT for Assessing Cognitive Processing Speed in Individuals with Multiple Sclerosis. Cognitive and Behavioral Neurology, 23(3), 192-198. DOI: 10.1097/WNN.0b013e3181cc8bd4 PMID: 20829669
49. Smith, A.M., Walker, L.A.S., Freedman, M.S., DeMeulemeester, C., & Hogan, M. (2009). fMRI investigation of disinhibition in cognitively impaired patients with multiple sclerosis. Journal of the Neurological Sciences, 281, 58-63. Published on-line (doi:10.1016/j.jns.2009.02.366). PMID: 19344919
50. Walker, L. & DeMeulemeester, C. (2008). Spontaneous intracranial hypotension masquerading as frontotemporal dementia. The Clinical Neuropsychologist, 22, 1035-1053. doi: 10.1080/13854040701874386 PMID: 18609334
51. Reicker, L. I., Tombaugh, T. N., Walker, L., Freedman, M. S. (2007). Reaction Time: An alternative method for assessing the effects of multiple sclerosis on information processing speed. Archives of Clinical Neuropsychology, 22, 655-664. https://doi.org/10.1016/j.acn.2007.04.008 PMID: 17532182
PubMed Listings
