Ottawa Hospital Research Institute

Research News

	Blood removal before major liver surgery cuts transfusions in half December 9, 2024 - Removing 10 per cent of a patient’s blood before major liver surgery and giving it back afterwards reduced transfusions by half, according to a large clinical trial published in The Lancet Gastroenterology & Hepatology.
	Researchers at The Ottawa Hospital awarded 19 CIHR grants worth more than $12 million July 20, 2022 - These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, muscle
	New research chair to lead cutting-edge work in liver and pancreatic cancer September 10, 2019 - The Ottawa Hospital and the University of Ottawa are pleased to announce the appointment of Dr. Guillaume Martel as the first Arnie Vered Family Chair in Hepato-Pancreato-Biliary Research.
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	The Ottawa Hospital awarded $12.7M for research, double the national CIHR success rate January 30, 2018 - Sixteen research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded $12.7 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). This represents a success r
	Does this liver surgery patient need a blood transfusion? New tool can help doctors decide September 21, 2017 - Health care providers now have a new tool to help decide whether a liver surgery patient needs a blood transfusion, thanks to a study led by Drs. Guillaume Martel and Dean Fergusson. Liver surgery often involves major bleeding, and about one in fou
	Surgeon looks to research to reduce blood transfusions during liver surgery February 3, 2017 - France Todd was part of a pilot study to reduce the amount of blood patients lose during liver surgery and limit their need for blood transfusions.

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Ardolino, Michele PhD	Senior Scientist (CR)	Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma	Basic research, Cancer immunotherapy, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Crawley, Angela Ph.D.	Senior Scientist (ICD)	Cancer, COVID-19, Hepatitis C, HIV, Infectious disease, Liver cancer, Liver disease	Basic research, Cancer immunotherapy, Clinical research, Disease models, Immunization, Immunotherapy, Molecular and cellular biology, RNA sequencing, Translational research
Dennis, Kristopher MD FRCPC PhD	Clinician Investigator (CR)	Cancer, Colorectal cancer, Gastric cancer, Liver cancer, Pain, Pancreatic cancer	Behaviour, Biomarkers, Clinical research, Clinical trials, Cohort studies, Health professional behaviour change, Health services research, Palliative care, Pragmatic trials, Qualitative methods, Quality Improvement, Systematic reviews
Gage, Blair PhD	Scientist (RM)	Bleeding disorders, Diabetes, Liver cancer, Liver disease, Vascular, heart and metabolic disease	Basic research, Bioinformatics, Cell therapy, Disease models, Gene expression, Gene therapy, Genetics, Genomics, Model organisms, Molecular and cellular biology, Regenerative medicine, Stem cells, Translational research, Transplantation
Martel, Guillaume MD, MSc (Epi), FRCSC, FACS	Senior Scientist (ACR)	Anemia, Bleeding disorders, Colorectal cancer, Liver cancer, Liver disease, Pancreatic cancer	Anesthesiology, Clinical research, Clinical trials, Peri-operative medicine, Surgery, Systematic reviews, Transfusions
McInnes, Matthew MD PhD FRCPC	Scientist (MIR)	Cancer, Liver cancer	Clinical research, Epidemiology, Health research methods, Imaging, Journalology, Systematic reviews
Nair, Vimoj MBBS MD MSc FRCPC	Clinician Investigator (CR)	Blood cancer, Brain cancer, Colorectal cancer, Gastric cancer, Liver cancer, Pancreatic cancer	Artificial intelligence and data science, Biostatistics, Cancer biotherapeutics, Clinical research, Clinical trials, Health technology, Imaging, Pragmatic trials, Quality Improvement, Translational research
Sim, Jordan	Clinician Investigator (ICD)	Liver cancer, Liver disease

Related Resources

Ottawa Hospital Research Institute Cancer Research Program

The Ottawa Hospital Cancer Program

Clinical Trials

The following list of clinical trials is pulled from ClinicalTrials.gov using the search terms "(liver cancer OR hepatic cancer OR hepatocellular carcinoma)” and “Ottawa Hospital.” More advanced search options are available. If you find a clinical trial that interests you, you can bring the information to the next appointment with your care team and ask if you are eligible for the study. If so, they may be able to refer you to the study team. Visit ohri.ca/patients to learn more about participating in research and clinical trials.

Note that ClinicalTrials.gov is hosted by the U.S. National Library of Medicine and is only available in English. Please note that we cannot guarantee a response from the person listed in the ‘Contact’ column.

Publications

The following research publications are pulled from PubMed using the search terms "liver cancer OR hepatic cancer OR hepatocellular carcinoma" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

Risk of Bias in Liver Imaging Reporting and Data System Studies Using QUADAS-2.
2025-05-01

Is concurrent LR-5 associated with a higher rate of hepatocellular carcinoma in LR-3 or LR-4 observations? An individual participant data meta-analysis.
2025-04-01

Current State of Evidence for Use of MRI in LI-RADS.
2025-02-21

Canadian Association of Radiologists Cancer Diagnostic Imaging Referral Guideline.
2025-01-22

Management and outcomes in patients with tumor thrombus: a retrospective cohort study.
2025-01-01

Do Risk Factors for HCC Impact the Association of CT/MRI LIRADS Major Features With HCC? An Individual Participant Data Meta-Analysis.
2024-12-29

WAW-TACE: A Hepatocellular Carcinoma Multiphase CT Dataset with Segmentations, Radiomics Features, and Clinical Data.
2024-11-01

Epidemiology, Treatment Patterns and Survival in Canadian Patients With Chronic Hepatitis B-Related Hepatocellular Carcinoma.
2024-11-01

Palliative radiotherapy versus best supportive care in patients with painful hepatic cancer (CCTG HE1): a multicentre, open-label, randomised, controlled, phase 3 study.
2024-10-01

Comparative Performance of 2018 LI-RADS versus Modified LIRADS (mLI-RADS): An Individual Participant Data Meta-Analysis.
2024-09-01

View more on PubMed