Ottawa Hospital Research Institute

Research News

	Vascular development may be at risk in autism July 13, 2020 - A Canadian collaboration led by Dr. Baptiste Lacoste has undertaken the first ever in-depth study of vasculature in the autistic brain. The product of four years of work, a paper published today in Nature Neuroscience lays out several lines of novel
	New mouse model to reveal insights into mild spinal muscular atrophy June 4, 2020 - Dr. Marc-Olivier Deguise from Dr. Rashmi Kothary’s team has developed a new mouse model of mild spinal muscular atrophy (SMA). Until now, researchers only had good animal models of the most severe forms of this disease.
	Chance discovery linking diet to type 1 diabetes started whole new field of research October 22, 2018 - In the early 1980's, Dr. Fraser Scott was conducting nutritional studies on rats that were supposed to develop type 1 diabetes—except they didn't. He discovered that changing the diet of these diabetes-prone rodents had prevented the disease. Making
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	Researchers awarded $1.7 M to tackle stroke and heart attack from multiple angles October 2, 2018 - Five groups from The Ottawa Hospital, affiliated with the University of Ottawa, were successful in the Heart and Stroke Foundation's recent grant competition. Drs. Dar Dowlatshahi, Tim Ramsay and Elizabeth Rochon were awarded $290,000* to test whethe

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Addison, Christina PhD	Senior Scientist (CR)	Bone and joint degeneration, Cancer, Lung cancer, Lung disease, Pancreatic cancer, Prostate cancer, Breast cancer	Basic research, Clinical research, Cohort studies, Disease models, Drug development, Genetics, Imaging, Model organisms, Translational research, Molecular and cellular biology
Ardolino, Michele PhD	Senior Scientist (CR)	Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma	Basic research, Cancer immunotherapy, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Brand, Marjorie PhD	Senior Scientist Affiliate (RM)	Blood cancer, Sickle cell anemia, Thalassemia, Vascular, heart and metabolic disease	Artificial intelligence and data science, Basic research, Bioinformatics, Disease models, Epigenetics, Gene expression, Genomics, Imaging, Model organisms, Molecular and cellular biology, Proteomics, Stem cells, Systems biology, Transgenic/knockout models
Burger, Dylan PhD	Senior Scientist (ICD)	Aging, Diabetes, Heart disease, Hypertension, Kidney disease, Maternal and fetal health, Obesity, Thrombosis / thromboembolism, Type 1 diabetes, Vascular cognitive impairment, Vascular, heart and metabolic disease	Basic research, Biomarkers, Disease models, Exercise, Extracellular vesicles / exosomes, Imaging, Model organisms, Molecular and cellular biology, Pharmacology, Proteomics, Regenerative medicine, Stem cells, Transgenic/knockout models, Translational research
Colavita, Antonio PhD	Senior Scientist (NS)	Spinal cord injury	Genetics, Model organisms, Molecular and cellular biology
Gage, Blair PhD	Scientist (RM)	Bleeding disorders, Diabetes, Liver cancer, Liver disease, Vascular, heart and metabolic disease	Basic research, Bioinformatics, Cell therapy, Disease models, Gene expression, Gene therapy, Genetics, Genomics, Model organisms, Molecular and cellular biology, Regenerative medicine, Stem cells, Translational research, Transplantation
Gray, Douglas PhD	Senior Scientist Emeritus (CR)	Aging, Cancer, Lung cancer, Parkinson's	Basic research, Disease models, Genomics, Imaging, Transgenic/knockout models, Genetics, Model organisms, Molecular and cellular biology
Kothary, Rashmi Ph.D.	Senior Scientist (RM)	Neuromuscular disease, Amyotrophic lateral sclerosis, Multiple sclerosis, Muscular dystrophy, Spinal muscular atrophy	Basic research, Disease models, Drug development, Epigenetics, Epigenetics, Gene therapy, Genetics, Imaging, Lipidomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Transgenic/knockout models, Translational research
Lacoste, Baptiste PhD	Senior Scientist (NS)	Stroke, Vascular cognitive impairment, Autism	Basic research, Disease models, Gene expression, Genomics, Stem cells, Genetics, Imaging, Model organisms, Molecular and cellular biology, Transgenic/knockout models
Lalu, Manoj MD, PhD, FRCPC	Scientist (ACR)	Blood cancer, COVID-19, Heart disease, Stroke, Vascular, heart and metabolic disease	Anesthesiology, Basic research, Cell therapy, Clinical research, Clinical trials, Disease models, Health research methods, Model organisms, Patient engagement, Regenerative medicine, Stem cells, Translational research
Mattar, Pierre PhD	Senior Scientist (RM)	Autism, Autoimmune diseases of the nervous system, Glaucoma, Intellectual disabilities, Macular degeneration, Retinal disease, Vision	Basic research, Bioinformatics, Cell therapy, Epigenetics, Gene expression, Genetics, Genomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Stem cells, Systems biology, Transgenic/knockout models
Ngsee, John Ph.D.	Affiliate Investigator (NS)	Amyotrophic lateral sclerosis, Dementia, Parkinson's	Cell therapy, Drug development, Model organisms, Molecular and cellular biology
Rudnicki, Michael OC, PhD, FRS, FRSC	Program Director and Senior Scientist (RM)	Muscular dystrophy, Neuromuscular disease	Basic research, Bioinformatics, Disease models, Epigenetics, Genetics, Genomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Stem cells, Transgenic/knockout models
Vanderhyden, Barbara PhD	Senior Scientist (CR)	Cancer, Infertility, Ovarian cancer, Women's health	Basic research, Bioinformatics, Biomarkers, Cancer biotherapeutics, Disease models, Drug development, Epigenetics, Gene expression, Genomics, Immunotherapy, Model organisms, Molecular and cellular biology, Oncolytic viruses, Stem cells, Transgenic/knockout models, Translational research, Viral therapy