Blair Gage

Blair Gage

PhD

Scientist, Regenerative Medicine

Ottawa Hospital Research Institute

Assistant Professor, Cellular and Molecular Medicine

University of Ottawa

Contact

613-737-8899, x 70339

Sandy Martino Research Administrative Assistant Tel:613-737-8899x76330 Email: smartino@ohri.ca

Research Groups

Research Group
Gage Lab
We explore what makes the cells that line your blood vessels (endothelium) different and special in each organ, especially the liver. This knowledg...

Bio

Blair K. Gage (PhD) is a Scientist at the Ottawa Hospital Research Institute in the Regenerative Medicine Program. He completed his postdoctoral studies with Dr. Gordon Keller at the McEwen Stem Cell Institute (Toronto, ON) after a PhD in Cell and Developmental Biology with Dr. Timothy Kieffer at the University of British Columbia (Vancouver, BC). His PhD work explored how transcription factors regulate the pancreatic endocrine cell subtypes that are formed from stem cells including human pluripotent stem cells. His postdoctoral work shifted to generate liver endothelium from human pluripotent stem cells to create potential cell-based and cell-informed therapeutics for liver disease and Hemophilia A. Before becoming an independent investigator at the OHRI in December 2023, Dr. Gage acquired numerous competitive funding scholarships and fellowships including those from NSERC, CIHR, Michael Smith Foundation, and Stem Cell Network.


News


Publications

Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells

2024-08-01 Go to publication

Erratum: Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors (Cell Reports (2022) 39(1), (S2211124722003692), (10.1016/j.celrep.2022.110621))

2022-01-01

Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors

2022-01-01

One‐Step Formation of Protein‐Based Tubular Structures for Functional Devices and Tissues

2021-04-01 Go to publication

Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts

2020-08-01 Go to publication

Huge thanks to all our funding sources!

Lab Funding:
2024/10 - 2029/01 Canadian Institutes of Health Research (CIHR) Regulating the Functions of Human Liver Sinusoidal Endothelial Cells to Fight Liver Disease

2024/06 Canadian Foundation for Innovation, John R. Evans Leaders Fund (CFI-JELF)
Designing, creating, and testing hPSC-based endothelial cell therapeutics for liver disease

2023/12 Ottawa Hospital Research Institute (OHRI)
Lab Start-up Funding

Personnel Funding:
2025 MSSRP
2025 BioTalent
2024 BioTalent

Related Research at The Ottawa Hospital