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Researchers at The Ottawa Hospital awarded 14 CIHR grants worth more than $10 million

Researchers at The Ottawa Hospital are leading 14 new projects funded by the Canadian Institutes of Health Research (CIHR) through the most recent operating grant competition.

These projects, worth more than $10 million, will advance science and improve health in diverse areas such as prostate cancer, thrombosis, hemorrhagic stroke, prenatal development, health misinformation, liver disease, subarachnoid hemorrhage, systematic review reproducibility, serotonergic psychedelics, disease reporting, virtual anesthesiology consultations, first-responder suicide, disease detection in pregnancy and language of care.

Our researchers are also co-leading grants administered at other institutions that are worth at least $3 million.

"Success at CIHR underscores the creativity, dedication and collaboration of our researchers and their teams. Funding for these innovative projects paves the way for groundbreaking advancement in biomedical sciences, improved patient care and progress towards better health on a global scale," said Dr. Rebecca Auer, Executive Vice-President, Research and Innovation at The Ottawa Hospital and professor at the University of Ottawa.

The Ottawa Hospital Research Institute (OHRI) had a success rate of 24% percent in this competition compared to the national average of 18% percent. The hospital currently ranks among the top four in the country for CIHR funding.

Successful CIHR Project Grants administered at OHRI

TRIPLE-SWITCH: A Randomized Clinical Trial for the Addition of Docetaxel to Androgen Receptor Pathway Inhibitors (ARPI) and Androgen Deprivation Treatment (ADT) in Patients with Metastatic Castration-Sensitive Prostate Cancer (mCSPC) and Suboptimal PSA Response- $2,487,015

  • Principal Investigator(s): Ong, Michael; Jafri, Mariam
  • Co-Investigator(s): Hotte, Sebastien; Reaume, Martin N; Parulekar, Wendy R; Brundage, Michael D; Wyatt, Alexander W; Soleimani, Maryam; Chi, Kim N; Pouliot, Frédéric; Ding, Keyue

Low-dose direct oral anticoagulant compared to aspirin for the thromboprophylaxis of patients with JAK2-positive myeloproliferative neoplasms- $1,350,226
 

  • Principal Investigator(s): Kimpton, Miriam; Delluc, Aurelien
  • Co-Investigator(s): Villeneuve, Pierre; Cerquozzi, Sonia; Cervi, Andrea L; Gauthier, Karine; Gupta, Vikas; Hayden, Anna; Hillis, Christopher M; Carrier, Marc; Siegal, Deborah M; Lazo-Langner, Alejandro; lee, Stephanie G; Melo Garcia, Luciana; Shivakumar, Sudeep P; Szuber, Natasha; Toupin, Dominique; Wu, Cynthia M; Ramsay, Timothy O; Habib, Laura Anne

 

International Care Bundle Evaluation in Cerebral Hemorrhage (I-CATCHER)- $1,300,500
 

  • Principal Investigator(s): Dowlatshahi, Dariush; Shamy, Michel C; Anderson, Craig S; Demchuk, Andrew M; Ferguson, Emma
  • Co-Investigator(s): Nicholls, Stuart G; Kelly, Michael; Lindsay, Mary Patrice; Thavorn, Kednapa; Singh, Nishita; Graham, Brett; Gioia, Laura C; Hu, Sherry X; Katsanos, Aristeidis; Schaafsma, Joanna D; Shoamanesh, Ashkan; Presseau, Justin; Verreault, Steve; Jalini, Shirin; Field, Thalia S; Swartz, Richard; Khaw, Alexander V; Kate, Mahesh P

Prenatal exposure of low-dose methylmercury causes abnormal neurodevelopment and its underlying mechanisms- $1,151,326
 

  • Principal Investigator(s): Wang, Jing; Chan, Laurie H

Targeting misinformation-associated health behaviours: Using the tools of implementation science - $983,024
 

  • Principal Investigator(s): Brehaut, Jamie C; Presseau, Justin
  • Co-Investigator(s): McCleary, Nicola; Patey, Andrea M; Nicholls, Stuart G; Weijer, Charles E; Graham, Ian D; Taljaard, Monica; Colquhoun, Heather

Regulating the Functions of Human Liver Sinusoidal Endothelial Cells to Fight Liver Disease- $856,800

  • Principal Investigator(s): Gage, Blair K
  • Co-Investigator(s): Andrews, Tallulah S

 

Establishing An International Core Outcome Set for Subarachnoid Hemorrhage (SAH) - What and How to Measure Outcomes in SAH Research- $726,752
 

  • Principal Investigator(s): English, Shane W; Marti, Maria Luisa; Presseau, Justin; Shea, Beverley J; Andersen, Christopher R
  • Co-Investigator(s): Delaney, Anthony; Marshall, Shawn C; Chasse, Michael; Lauzier, François; McIntyre, Lauralyn A; Tugwell, Peter S; Fergusson, Dean A; Niznick, Naomi; Turgeon, Alexis F; Blain-Moraes, Stefanie; Terrett, Luke A; Zha, Xiaohui; Redekop, Gary J; Algird, Almunder; Scales, Damon C; Kramer, Andreas H; Kutsogiannis, Demitrios J; Pickett, Gwynedd E; Sadan, Ofer; Ramsay, Timothy O; Miller, Leslie A; Bulters, Diederik

Reproducibility of systematic reviews with meta-analysis: relevance to clinical practice guidelines- $360,138
 

  • Principal Investigator(s): Moher, David
  • Co-Investigator(s): Sulis, Giorgia; Little, Julian; Bodnaruc, Alexandra M; Munn, Zachary; Page, Matthew J; Tricco, Andrea C; Brouwers, Melissa C

A living systematic review, meta-analysis and dose-response of randomized controlled trials testing serotonergic psychedelics: efficacy, acceptability, tolerability, safety and publication bias within and across health conditions- $348,076
 

  • Principal Investigator(s): Solmi, Marco; Veroniki, Areti Angeliki
  • Co-Investigator(s): Fiedorowicz, Jess G; Hatcher, Simon; Husain, Muhammad I; Fabiano, Nicholas; Rosenblat, Joshua D; Ladha, Karim; Mayo, Leah M; Nicholls, Stuart G; Tanuseputro, Peter; Wong, Stanley K; Myran, Daniel; Shlik, Jakov; White, Tracy; Moher, David; Saraf, Gayatri; Rubaiyat, Arafat R; Yatham, Lakshmi N

Development of reporting guidelines for modelling studies of noncommunicable diseases- $320,536
 

  • Principal Investigator(s): Manuel, Douglas G; Mytton, Oliver
  • Co-Investigator(s): Moher, David; Rahgozar, Arya; Webber, Laura; Amini, Seyed M; Presseau, Justin; Meza, Rafael; van Allen, Zack; Bennett, Carol; Hennessy, Deirdre A; Fisher, Stacey L

VIRTUAL Study: Virtual vs In peRson comparaTive effectiveness evaluation of Anesthesiology consuLtations- $271,576
 

  • Principal Investigator(s): McIsaac, Daniel I; Trivedi, Vatsal; Moloo, Husein; Holst, Patricia A; Wijeysundera, Duminda N
  • Co-Investigator(s): Pelland, Amélie M; Wyand, Anna E; Berrio Valencia, Marta; Gagné, Sylvain; Ke, Xue Chen; Lalu, Manoj M; Breau, Rodney H; Lavallée, Luke T; Martel, Guillaume; Bryson, Gregory L; Beckerleg, Weiwei; Hallet, Julie; McIsaac, Sarah; Flexman, Alana M; Boet, Sylvain; Aucoin, Sylvie D; Van Walraven, Carl; Hladkowicz, Emily; Ip, Vivian; Taljaard, Monica; Talarico, Robert F; Engel, Jake; Kobewka, Daniel M; Martin, Janet; MacDonald, David B

The experience of public safety personnel (PSP) families after a suicide and PSP organizations response to a suicide: A qualitative study and creation of a family-centred response guide to PSP suicides- $267,751
 

  • Principal Investigator(s): Hatcher, Simon; Cramm, Heidi
  • Co-Investigator(s): Campbell, Margaret; Ricciardelli, Rose; Genest, Christine; Wieler, Lisbeth A; MacLean, Sarah


Respiratory Assessment among Pregnant Individuals for Detecting febrile infections in Ottawa, Ontario- $100,000

  • Principal Investigator(s): El-Chaâr, Darine; McGuinty, Michaeline
  • Co-Investigator(s): Wilson, Kumanan; Walker, Mark C; Dunn, Sandra I; Cook, Jocelynn L; Cameron, D.William; Fakhraei, Romina; Rennicks White, Ruth; Clancy, Aisling A; Walker, Heather A; Scremin Souza, Sara

The impact of language on care and outcomes in patients with prostate or breast cancer- $100,000

  • Principal Investigator(s): Wang, Tzu-Fei; Tanuseputro, Peter
  • Co-Investigator(s): Carrier, Marc; Xu, Yan; Backman, Chantal; Webber, Colleen; Kehoe MacLeod, Krystal J; Fisher, Stacey L; Li, Wenshan; Myran, Daniel; Reaume, Michael; Johnston, Sharon E; Patel, Kruti; Bossé, Dominick; Awan, Arif A; Forgues, Eric; Batista, Ricardo; Cheung, Angela; Moledina, Aliza; Cole, Katherine M; Ong, Michael

Successful CIHR Project Grants with OHRI PIs - administered at another institution

Effects of donor-recipient sex-matched versus sex-mismatched red blood cell transfusion on outcomes in critically ill adult patients- $2,084,624

  • Principal Investigator(s): Michelle Paula Zeller, Dean A Fergusson
  • Co-Investigators: Acker, Jason P; Adhikari, Neill K; Arnold, Donald M; Callum, Jeannie L; Cook, Richard J; English, Shane W; Heddle, Nancy M; Lin, Yulia; Pendergrast, Jacob M; Rochwerg, Bram N; Shih, Andrew W; Solh, Ziad; Webert, Kathryn E; Xie, Feng
  • Note: this grant is administered at McMaster University

Altering the gut microbiome in triple-negative breast cancer: a pilot study - $1,510,875

  • Principal Investigator(s): Dr. Mark Basik, Dr. Saman Maleki, Dr. Terry L. Ng
  • Co-Investigators: Dr. Adriana Aguilar, Dr. S. Parvathy, Dr. Jacques Raphael, Dr. Michael Silverman
  • Note: this grant is administered at CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Jewish General

Establishing the Framework for Decentralized Hepatitis C Point-of-Care Testing and Treatment in Canada: An Implementation Science-based Approach - $656,371

  • Principal Investigator(s): Fontaine, Guillaume; Bartlett, Sofia R; Biondi, Mia J; Dickie, Melisa C; Feld, Jordan J; Grebely, Jason; Klein, Marina B; Presseau, Justin
  • Co-Investigators: Barnett, Tamara L; Bruneau, Julie; Dunn, Kate; Elakpa, Daniel N; Etherington, Cole; Gilbert, Mark P; Greenaway, Christina A; Janjua, Naveed Z; Jassem, Agatha N; Mendlowitz, Andrew B; Taylor, Natalie J; Vesnaver, Elisabeth
  • Note: this grant is administered at CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Jewish General

Redéfinir la neuro-imagerie pour les patients âgés/adultes souffrant de traumatisme crâniocérébral léger- $1,189,576

  • Principal Investigator(s): Emond, Marcel; Benhamed, Axel; Blanchard, Pierre-Gilles; D'Astous, Myreille; Malo, Christian; Yadav, Krishan
  • Co-Investigators: Balen, Frederic; Batomen Kuimi, Brice Lionel; Berger Pelletier, Elyse; Brousseau, Audrey-Anne; Brubacher, Jeffrey R; Clark, Greg; de Wit, Kerstin; Ellis, Brittany; Lessard, Justine; Mercier, Eric; Ringuette Goulet, Cassandra; Stiell, Ian G
  • Note: this grant is administered at Université Laval

Renin-Guided Therapy with Mineralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study (RETAME-PA)- $260,000

  • Principal Investigator(s): Remi Goupil, Greg Hundemer, Greg Kline, and Alex Leung
  • Co-Investigators: Agharazii, Mohsen; Bourdeau, Isabelle; Collister, David; Dubrofsky, Lisa; merabtine, amel; Nadeau-Fredette, Annie-Claire; Prebtani, Ally; Tennankore, Karthik K
  • Note: this grant is administered at CIUSSS du Nord-de-l'Ile-de Montréal - Hôpital Sacré Coeur

Accelerating and standardizing assessment of acute lung injury using an artificial intelligence based approach - $100,000

  • Principal Investigator(s): Arvind Mer, Manoj Lalu
  • Principal Knowledge User: Patricia Liaw
  • Co-Investigators: Dean Fergusson, Sean Gill, Majid Komeili, Braedon McDonald, Haibo Zhang
  • Collaborators: Julie Bastarache, Angela Crawley, Claudia Dos Santos, Alison Fox-Robichaud, Arnold Scott Kristof, Christian Lehmann, Arya Rahgozar, Patricia Rocco, Eric Schmidt, Duncan Stewart, Bernard Thebaud
  • Collaborator Patient Partners: Marie-Maxime Bergeron, Laurie Proulx, Sehar Saeed
  • Note: this grant is administered at uOttawa

Network renewals with OHRI PIs - administered at another institution

 Canadian Immunization Research Network (CIRN) Renewal -$15,000,000

  • Principal Investigator(s): Halperin, Scott A; Andrew, Melissa K; Bettinger, Julie A; Bolotin, Shelly; Brisson, Marc; Buchan, Sarah; Cowan, Juthaporn; Dubé, Eve; Greyson, Devon; Hatchette, Todd F; Heffernan, Jane M; Kwong, Jeffrey C; Langley, Joanne M; MacDonald, Shannon E; McNeil, Shelly A; Muller, Matthew P; Parsons Leigh, Jeanna J; Sadarangani, Manish; Top, Karina A
  • Co-Investigators: Abu-Raya, Bahaa H; Alcantara, Joenel; Boivin, Guy; Brousseau, Nicholas; Buchan, Catharine A; Burchell, Ann N; Burton, Catherine; Carazo, Sara; Cheng, Matthew P; Comeau, Jeannette L; Constantinescu, Cora M; Cooper, Curtis L; Deeks, Shelley L; Dionne, Marc; Driedger, S. Michelle; Elsherif, MAY S; Fitzpatrick, Tiffany; Gantt, Soren M; Graham, Janice E; Halperin, Donna M; Isenor, Jennifer; Janjua, Naveed Z; Jardine, Cynthia; Jassem, Agatha N; Jubis, Vanessa; Katz, Kevin C; Kellner, James D; Kiely, Marilou; LeBlanc, Jason J; Loeb, Mark B; McGeer, Allison J; Meier-Stephenson, Vanessa; Meyer, Samantha; Moghadas, Seyed M; Morris, Shaun K; Mulpuru, Sunita; O'Brien, Celine Y; Papenburg, Jesse; Perez, Samara; Pernica, Jeffrey; Pham-Huy, Anne; Quach-Thanh, Caroline; Rizzuti, Francesco A; Rosberger, Zeev; Rouleau, Isabelle; Salter, Katherine; Shapiro, Gilla; Sheffield, Holden; Smith, Stephanie W; Smolarchuk, Christa D; Tremblay, Cécile L; Trottier, Sylvie; Ulanova, Marina; Valiquette, Louis; Vanderkooi, Otto G; Verschoor, Chris P; Vivion, Maryline; Ward, Brian J; Wilson, Sarah; Witteman, Holly M
  • Note: this grant is administered at Dalhousie University (Nova Scotia)

These projects are supported by core resources for research at The Ottawa Hospital, such as the Ottawa Methods Centre.

The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation. Learn more about how research is funded.

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The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation.