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New Canada Research Chairs to advance regenerative medicine, thrombosis and stroke research at The Ottawa Hospital
November 14, 2024
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The federal government announced a new round of Canada Research Chairs this week, including three based at The Ottawa Hospital.
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Honouring our top researchers of 2024
November 7, 2024
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Each year, The Ottawa Hospital and its Research Institute honour a small number of outstanding researchers for discoveries and innovations that are improving patient care at TOH and advancing science around the world.
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$2.8M grant to support Canada-wide trial of cell therapy for preterm babies
September 16, 2024
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“This trial could change the way we care for premature babies. It’s my hope that these tiny patients will have a better chance to thrive, grow up, and have an impact on the world around them."
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Satellos Bioscience wins top company award and rings TSX bell
May 24, 2024
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Satellos Bioscience, a start-up company founded by Dr. Michael Rudnicki, received the prestigious Company of the Year Award from Life Sciences Ontario and opened the Toronto Stock Exchange last week.
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The Ottawa Hospital’s new campus to become a hub for biotherapeutics research and manufacturing thanks to $59M grant
May 6, 2024
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The Ottawa Hospital is receiving $59 million to boost Canada’s capacity to develop and manufacture life-saving biotherapeutics, including vaccines, gene therapies and cell therapies.
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Two decades in the making — world-first trial aims to heal the lungs of preemies
May 1, 2024
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Emmy Cogan entered this world weighing barely more than a pound. This tiny warrior made history by becoming the first baby in North America to receive a world-first cell therapy trial to heal the lungs of preterm babies
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Which cells have the greatest potential to repair the lungs of pre-term babies?
April 23, 2024
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Dr. Bernard Thébaud and his team have uncovered which types of mesenchymal stromal cells (MSCs) are the best at healing lung injury in the lab.
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Are EVs travelling to injured lungs?
March 15, 2024
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Tiny particles called extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have shown clear potential to treat several lung diseases in animal models by reducing inflammation. However, there has been debate about where MSC-EVs end u
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ELEVATE seed grants to help researchers at The Ottawa Hospital improve treatment for inflammatory and immune conditions
February 21, 2024
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The Ottawa Hospital’s Research Institute is awarding four ELEVATE seed grants to help researchers understand the role of inflammation and the immune system in various diseases and develop better treatments.
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Tiny trailblazer: First baby treated in world-first trial for chronic lung disease
January 19, 2024
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Emmy Cogan was the first baby treated in a world-first clinical trial of a cell therapy for bronchopulmonary dysplasia.
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New scientist profile: Dr. Blair Gage uses stem cell biology to build blood vessels and develop new treatments
January 2, 2024
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As a self-proclaimed “cell therapist,” Dr. Blair Gage aims to understand what makes stem cells tick and then gently coax them to realize their full potential.
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Biotherapeutics Manufacturing Centre makes ‘living therapies’ for people in Ottawa and beyond
December 15, 2023
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The Ottawa Hospital’s BMC is a hidden jewel that is helping Ottawa become a leading city for developing new therapies
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Making ‘living therapies’: The Ottawa Hospital’s Biotherapeutics Manufacturing Centre plays critical role in Ontario life sciences sector
October 2, 2023
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Biotherapeutics have enormous potential to improve health and save lives and Ontario has the potential to lead the way in manufacturing these innovative therapies.
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Tiny Cells for Tiny Lungs
September 28, 2023
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“Stem cells used to be something that were grown in a petri dish. They are now game-changing therapies with live-saving potential for even the tiniest of patients.”
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Stem cell treatment banishes disease for MS patient
April 2, 2023
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John Chafe had a job in a bank with the goal of running it one day. But his plans were sidetracked by an aggressive form of multiple sclerosis (MS). In 2001, he became the second person in a world-first clinical trial of its kind that virtually elimi
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After 18 years with MS—“I really feel like I’m cured.”
April 2, 2023
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“It’s now 12 years since my stem cell transplant. I really feel like I’m cured,” said Heather Harris, who has no symptoms of the disease. She works full-time as a school principal, and is back to camping, skiing, running and driving a manual shift ca
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First patient treated in world-first cell therapy trial to heal the lungs of preterm babies
March 23, 2023
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Researchers have treated the first patient in an innovative clinical trial of a cell therapy that aims to prevent very premature babies from developing a chronic lung disease called bronchopulmonary dysplasia (BPD). This is the first trial of its kin
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Moving the needle forward on sepsis research with a world-first clinical trial
March 16, 2023
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The search for the silver bullet for sepsis has been decades in the making. However, The Ottawa Hospital is taking a big step forward in the next phase of a world-first clinical trial using stem cells in patients with septic shock.
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Meet Dr. Manoj Lalu, the clinician-scientist bringing lab discoveries to patients every day
March 16, 2023
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From looking at how we can use stem cells to treat diseases like sepsis to dealing with patients directly in the ICU and OR, Dr. Lalu is making an impact behind the scenes and beyond.
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Meet Dr. Lauralyn McIntyre — sepsis researcher and clinician extraordinaire
March 16, 2023
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Dr. Lauralyn McIntyre’s path to The Ottawa Hospital wasn’t necessarily a direct one — it took her all over Ontario and out west to the mountains — but she couldn’t do her groundbreaking sepsis research anywhere else, or with any other team.
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The Ottawa Hospital, the University of Ottawa, and McMaster University join forces to prepare Canada for future pandemics
March 2, 2023
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Building on the knowledge gained over nearly three years of the COVID-19 pandemic, The Ottawa Hospital (TOH), the University of Ottawa and McMaster University are joining forces with partners to create the Canadian Pandemic Preparedness Hub (CP2H).
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Clinical trial will test promising cell therapy for septic shock
January 19, 2023
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Dr. Lauralyn McIntyre was awarded $1.6 million from the Canadian Institutes of Health Research Clinical Trials Fund to conduct a Phase II clinical trial of mesenchymal stem cells (MSCs) in patients with septic shock.
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Canadian-Led Immunotherapies in Cancer (CLIC) program inspires innovative CAR-T trial in Denmark
December 8, 2022
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CAR-T therapy is a groundbreaking cancer treatment that involves genetically engineering a patient’s own immune cells to attack their cancer. While this therapy is commercially available in many countries, cancer researchers are also developing their
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Huge hope for our smallest patients
November 2, 2022
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Dr. Bernard Thébaud clearly remembers the day he decided to become a doctor—his dad had suggested the soccer-loving teen become a sports physician. But from the first day of his pediatric surgery rotation, Dr. Thébaud knew he wanted to help
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“Dream team” of researchers tackles leading cause of vision loss
July 27, 2022
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Dr. Catherine Tsilfidis has assembled a world-class team to bring discoveries with game-changing potential to patients with retinal disease
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Researchers at The Ottawa Hospital awarded 19 CIHR grants worth more than $12 million
July 20, 2022
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These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, muscle
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First made-in-Canada CAR-T cell therapy for cancer shows promise in clinical trial
June 17, 2022
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More than a dozen people with cancer who had exhausted all treatment options are alive and cancer-free today thanks to a pioneering Canadian clinical trial of a highly personalized kind of immunotherapy.
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Meet brain and eye researcher Dr. Pierre Mattar
April 25, 2022
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Dr. Pierre Mattar is doing the groundwork needed to develop treatments for vision loss
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First made-in-Canada CAR-T therapy gives lymphoma patient a third chance
January 10, 2022
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Faced with the return of his lymphoma for the third time in ten years, Owen Snider was running out of options. But there was new hope when he was accepted into a made-in-Canada CAR-T therapy clinical trial.
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Medicine’s future: living drugs
November 19, 2021
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The Ottawa Hospital’s Biotherapeutics Manufacturing Centre harnessing the life-saving power of biological therapies
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$2.4 M grant to help researchers develop gene and cell therapies for a leading cause of blindness
September 15, 2021
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A team led by Dr. Catherine Tsilfidis has received $2.4 M from the Ontario Research Fund to develop treatments for retinal diseases, a leading cause of blindness.
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Biomanufacturing partnership boosts Canada’s life-saving treatment and vaccine capacity
September 13, 2021
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As Canada seeks to rebuild its biomanufacturing sector and support made-in-Canada solutions to global health challenges, The Ottawa Hospital, the University of Alberta and BioCanRx have collaborated to create Canada’s first full-service, end-to-end b
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Biotherapeutics: the future of medicine
May 25, 2021
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World-class biotherapeutics facility at The Ottawa Hospital uses cells, genes and viruses to create unique life-saving treatments
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Experts on call: Stem cells, gene therapy and biotherapeutics
April 22, 2021
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Could biotherapeutics be the key to the next wave of medical breakthroughs? Join this lively discussion to learn how researchers at The Ottawa Hospital are using biological materials like cells, genes and viruses to heal the body and fight disease.
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Grateful COVID-19 patient gives back by participating in research
April 13, 2021
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Sharon Charlebois doesn’t remember much about the 25 days she spent at The Ottawa Hospital fighting a severe case of COVID-19 in January 2021. Now that she’s recovering at home with her husband, some memories come back to her in flashes.
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The rise of point-of-care cell manufacturing
March 12, 2021
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Decentralized approach represents a paradigm shift in the way Canada studies, commercializes and delivers stem cell treatments for serious diseases
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Cancer team awarded $5M for cell-based immunotherapy research
March 3, 2021
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Researchers at The Ottawa Hospital and the University of Ottawa are partnering with colleagues across the country to expand Canada’s capacity to develop new cell-based immunotherapies for cancer with a $5.2 million grant from the Canada Foundation fo
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One small step for blood cancer patients, one giant step for Canadian cancer patients of all stripes
February 25, 2021
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The Canadian-Led Immunotherapies in Cancer (CLIC) research program is building Canada’s capacity for innovation in CAR-T therapy, with support from BioCanRx, The Ottawa Hospital, BC Cancer and the Ontario Institute for Cancer Research
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Experimental stem cell therapy a potential weapon against COVID-19
February 1, 2021
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Drs. Duncan Stewart, Shane English, Dean Fergusson and colleagues have launched a clinical trial to test MSCs in people with severe COVID-19.
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$1M investment fuels development of new therapies for Duchenne muscular dystrophy
February 1, 2021
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Parent Project Muscular Dystrophy has invested $1M in Satellos Bioscience, a startup company founded by Dr. Michael Rudnicki.
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$1M grant to support manufacturing of COVID-19 treatments and vaccines at The Ottawa Hospital and uOttawa
November 6, 2020
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Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $1,050,000 from the Canada Foundation for Innovation to support facilities for manufacturing innovative treatments and vaccines for COVID-19.
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The Ottawa Hospital and uOttawa launch new cancer immunotherapy research projects with funding from BioCanRx
September 22, 2020
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BioCanRx, Canada’s Immunotherapy Network, today announced funding of $10M for 14 cancer immunotherapy research projects and eight core and biomanufacturing facilities across the country. Researchers at The Ottawa Hospital (TOH) and the University of
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Experimental Stem Cell Therapy a Potential Weapon in COVID-19 Fight
May 28, 2020
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Ottawa-based researchers pivot at lightning speed to launch study on treating related respiratory failure
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COVID-19 research on cell therapy, drug screening and marginalized populations funded through Ontario’s Rapid Research Fund
May 21, 2020
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Researchers from The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded almost $2 million from Ontario’s COVID-19 Rapid Research Fund for three research projects that could help in the fight against the virus. These three pr
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Harnessing stem cells and regenerative medicine to fight COVID-19
April 23, 2020
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Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $490,000 from the Stem Cell Network for two research projects that could help in the fight against COVID-19. These peer-reviewed grants are part of an overall investm
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Researchers join the fight against COVID-19
April 2, 2020
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As hospitals and communities band together to fight COVID-19, researchers at The Ottawa Hospital are harnessing their unique expertise and resources to help.
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Stem cells may heal lungs of premature babies
March 4, 2020
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Premature babies need extra oxygen and mechanical intervention to breathe but this can damage their lungs, causing a chronic lung disease. A stem cell treatment soon to be tested in clinical trials at The Ottawa Hospital may help heal the lungs of pr
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Could umbilical cord cell therapy help premature babies? Dr. Bernard Thébaud awarded $638,000 from Stem Cell Network for clinical trial
March 2, 2020
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Dr. Bernard Thébaud and colleagues received $638,000 from the Stem Cell Network with in-kind matching funds from MDTB Cells GmbH to conduct a phase 1 clinical trial of umbilical cord cell therapy for premature babies.
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Cell therapy for premature babies: new lab study suggests wider treatment window may be possible
February 19, 2020
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Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by the breathing equipment that keeps premature babies alive.
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Acute kidney injury and chronic kidney disease— newfound hope for treatment
September 12, 2019
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Researchers at The Ottawa Hospital are working together to help prevent and treat acute kidney injury and chronic kidney disease.
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The promise of CAR-T therapy for cancer: meta-analysis shows the big picture
August 14, 2019
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CAR-T therapy, which uses a patient’s own genetically modified immune cells, is one of the most exciting advances in cancer treatment. To get a big picture view of the field, Drs. Manoj Lalu and Dean Fergusson led a team that analyzed data from nearl
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Autologous hematopoietic stem cell transplantation recommended as a standard of care for certain kinds of MS in the U.S.
March 13, 2019
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The American Society for Blood and Marrow Transplantation has recommended that stem cell transplantation for MS, which has been pioneered at The Ottawa Hospital, be considered a “standard of care, clinical evidence available” for people with certain
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Patients and clinical trial experts key to upcoming made-in-Canada CAR-T clinical trial
March 1, 2019
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Researchers at The Ottawa Hospital and the University of Ottawa are known around the world for their expertise in designing and leading clinical trials, and they're now applying this knowledge to create a made-in-Canada approach for CAR-T cell cl
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Using stem cells to treat brain cancer: pilot study highlights potential new approach
August 16, 2018
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Stem cells are usually associated with repairing damaged tissue and treating degenerative diseases, but they also have a unique property that may be harnessed to fight cancer. When injected into the body, stem cells naturally migrate to tumours, and
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Experimental stem cell therapy tested for rare lung disease
April 30, 2018
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A Canadian-led research team has launched a clinical trial of an experimental stem cell therapy for pulmonary arterial hypertension. This rare and deadly disease occurs when the arteries that supply blood to the lungs become so damaged that blood can
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Could stem cells repair the heart, fight infections, mend premature lungs, and heal the brain after stroke?
April 11, 2018
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Ottawa researchers closer to finding out, thanks to $999,900 from the Stem Cell Network
Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks
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Pre-treated cells boost blood vessel repair
November 29, 2017
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Endothelial colony-forming cells (ECFCs) are stem-like cells found in umbilical cord blood that help repair damaged blood vessels. They may hold promise for the treatment of stroke, heart attack and blocked leg arteries. However, their rate of bloo
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Stem cells for septic shock: world-first trial establishes safety, sets stage for larger trial
November 2, 2017
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Stem cells are usually thought of as the building blocks of the body – able to give rise to all our cells and organs. But Dr. Lauralyn McIntyre, Dr. Duncan Stewart, Dr. Dean Fergusson and their colleagues are testing the idea that certain stem cells
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Ottawa scientist wins Canada's top stem cell prize for multiple sclerosis trial
September 6, 2017
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Dr. Harold Atkins, stem cell transplant physician and scientist at The Ottawa Hospital and the University of Ottawa, will receive the prestigious Till & McCulloch Award for “exceptional contributions to global stem cell research.” The award will
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Ottawa researchers to play lead role in new cancer immunotherapy studies
February 15, 2017
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BioCanRx funds research into CAR-T and virus-infected cell therapy
Researchers from The Ottawa Hospital and the University of Ottawa will play a lead role in cutting-edge research on cancer immunotherapy, thanks to five new peer-reviewed researc
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