Natasha Kekre

Natasha Kekre

BSc, MD, MPH, FRCPC

Scientist, Cancer Research

Ottawa Hospital Research Institute

Hematologist, Transplant and Cellular Therapy Program

The Ottawa Hospital

Research Chair, Advanced Stem Cell Therapy

Ottawa Hospital Research Institute

Acting Associate Program Director, Cancer Research

Ottawa Hospital Research Institute

Associate Professor, Faculty of Medicine

University of Ottawa

Contact

6137378899 x. 73904

501 Smyth Road CPCR Box 201A Ottawa, ON K1H 8L6

Research Groups

Bio

Dr. Natasha Kekre has been appointed to the Department of Medicine in the Division of Hematology, within the Transplant and Cellular Therapy Program at The Ottawa Hospital, effective October 2015. She is also an associate scientist within the Ottawa Hospital Research Institute and an associate professor of medicine at the University of Ottawa. She completed her Bachelor’s in Science at the University of Windsor then obtained her medical degree from the University of Ottawa. She then trained at the University of Ottawa in Internal Medicine and Hematology. She went on to do a fellowship in stem cell transplantation at Dana Farber Cancer Institute in Boston, MA with a Masters in Public Health from Harvard University

Her research is focused on developing early phase clinical trials and moving home grown therapeutic strategies into patients. She collaborates with a number of local investigators and scientists in Ottawa, studying hematologic malignancies and blood and marrow transplant recipients more specifically. She collaborates with scientists and physicians across Canada to build a Canadian CAR-T cell platform (chimeric antigen receptor T cells are immune cells engineered to kill cancer cells), bringing this exciting therapy to Canadian patients. Her other clinical research interests include improving transplant and CAR-T related outcomes, learning from current and future transplant and CAR-T treatment platforms. 

She also participates with a number of cooperative groups in North America including the Center for International Blood and Marrow Transplant Research and Cell Therapy Transplant Canada. She has built worldwide collaborations with scientists, physicians and regulators to improve access and innovation in the CAR-T and immune therapy space globally.

Research Goals and Interests

Cellular immunotherapy (CAR-T cells)
Hematopoietic Stem Cell Transplantation
Leukemia
Lymphoma
Clinical Epidemiology 

1) Translational Medicine: Collaborating with laboratory scientists, students, and technicians to translate bench-side cancer research into clinical trials for patients.

2) Cellular Immunotherapy: Partnering with physicians and researchers across Canada to advance Chimeric Antigen Receptor T-cell (CAR-T) therapy through the Canadian-Led Immunotherapies in Cancer (CLIC) program, making innovative treatments accessible to Canadian patients.

3) Hematologic Malignancies: Focused on improving outcomes for recipients of stem cell transplants and CAR-T therapies, with an emphasis on long-term recovery and disease management.

4) Clinical Epidemiology: Applying statistical methods in health economics, patient-reported outcomes, engagement strategies, and systematic reviews to enhance care for patients with hematologic cancers, particularly those undergoing transplantation.


News


Publications

Daratumumab for Posttransplant Autoimmune Hemolytic Anemia

2025-06-01 Go to publication

Impact of Day 11 Methotrexate Dose Adjustments due to Mucositis on the Outcomes Following Allogeneic Stem Cell Transplant in the Setting of Anti Thymocyte Globulin (ATG) Based GVHD Prophylaxis

2025-05-01 Go to publication

Point-of-care CAR T manufacturing solutions: can 1 model fit all?

2024-12-10 Go to publication

Engaging Patients and Caregivers in an Early Health Economic Evaluation: Discerning Treatment Value Based on Lived Experience

2022-11-01 Go to publication

Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia

2019-10-22 Go to publication

Related Research at The Ottawa Hospital