David Cook

David Cook

PhD

Scientist, Cancer Research

Ottawa Hospital Research Institute

Assistant Professor, Department of Cellular and Molecular Medicine

University of Ottawa

Contact

613-737-7700 ext 70335

Ottawa Hospital Research Institute Centre for Cancer Therapeutics 501 Smyth Road Box 926 Ottawa, ON K1H 8L6

Research Groups

Research Group
Cook Lab
Treatment options for ovarian cancer are limited, and while tumours often respond to initial treatments, many recur and become resistant to therapy...

Bio

Dr. Cook obtained his PhD with Dr. Barbara Vanderhyden from the University of Ottawa, combining high-throughput screening and single-cell genomics to study epithelial-mesenchymal plasticity in cancer. This phenomenon describes the capacity of malignant cells to dedifferentiate, increasing their ability to invade surrounding tissue, evade immune detection, and resist therapeutics. During this period, he also worked on preclinical models of ovarian cancer to study disease biology and therapeutic testing. For his postdoctoral studies, Dr. Cook worked with Dr. Jeff Wrana (Lunenfeld-Tanenbaum Research Institute, Toronto, ON) to study how cellular phenotypes and tissue structure influence one another.

Dr. Cook is a recipient of the CIHR Banting Fellowship, the OICR Rising Star Award, and the Worton Researcher in Training Award.


News


Publications

Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets

2025-12-03 Go to publication

Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension

2025-10-28 Go to publication

LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs

2025-01-01

Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells

2024-01-01

The Drosophila adult midgut progenitor cells arise from asymmetric divisions of neuroblast-like cells

2024-01-01

Related Research at The Ottawa Hospital