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Lung cancer

Researchers at The Ottawa Hospital are investigating promising new approaches to prevent, diagnose and treat lung cancer. This page includes selected news stories about our lung cancer research, links to researchers working in this area and related resources.

Research News

Capturing immunotherapy response in a blood drop
October 26, 2023 - A clinical trial published in Nature Medicine suggests that using a “liquid biopsy” to measure tiny bits of tumour DNA in blood could determine if immunotherapy drugs are working in patients with advanced non-small cell lung cancer.
How a lung cancer survivor advocate is helping advance research that will lead to early detection
February 7, 2020 - In September of 2013, Jill Hamer-Wilson caught something many of us tend to catch this time of year – a cold. While the cold eventually went away, a cough remained, and lingered for quite some time. Little did Jill know that this was an early sign of
3D gel helps researchers find potential drugs for lung cancer, other diseases
March 15, 2019 - Researchers in Ottawa and Toronto have created a spongy 3D gel that mimics lung tissue, allowing them to quickly screen hundreds of potential drugs for lung cancer and other diseases.
Show more news stories


Name Scientific appointment Diseases, conditions and populations of interest Research and clinical approaches
Addison, Christina
Senior Scientist
(Cancer Therapeutics)
Bone and joint degeneration, Cancer, Lung cancer, Lung disease, Pancreatic cancer, Prostate cancer, Breast cancer Basic research, Clinical research, Cohort studies, Disease models, Drug development, Genetics, Imaging, Model organisms, Translational research, Molecular and cellular biology
Ardolino, Michele
Senior Scientist
(Cancer Therapeutics)
Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma Basic research, Cancer immunotherapy, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Gilbert, Sebastien
Clinician Investigator
(Clinical Epidemiology)
Cancer, Gastric cancer, Gastrointestinal disease, Gastrointestinal stromal tumours (GIST), Lung cancer, Lung disease Artificial intelligence and data science, Clinical research, Epidemiology, Health technology, Quality Improvement
Gray, Douglas
Senior Scientist Emeritus
(Cancer Therapeutics)
Aging, Cancer, Lung cancer, Parkinson's Basic research, Disease models, Genomics, Imaging, Transgenic/knockout models, Genetics, Model organisms, Molecular and cellular biology
Islam, Shahidul
Clinician Investigator
(Cancer Therapeutics)
Cancer, Endometrial cancer, Lung cancer, Ovarian cancer, Thyroid cancer
Ramsay, Timothy
Senior Scientist
(Clinical Epidemiology)
Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, Dystonia, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Stanford, William
Senior Scientist
(Regenerative Medicine)
Aging, Blood cancer, Cancer, COVID-19, Lung cancer, Lymphangioleiomyomatosis (LAM), Vascular, heart and metabolic disease Artificial intelligence and data science, Molecular and cellular biology, Regenerative medicine, Stem cells, Systems biology

Clinical Trials

The following list of clinical trials is pulled from using the search terms "Lung cancer” and “Ottawa Hospital.” More advanced search options are available. If you find a clinical trial that interests you, you can bring the information to the next appointment with your care team and ask if you are eligible for the study. If so, they may be able to refer you to the study team. Visit to learn more about participating in research and clinical trials.

Note that is hosted by the U.S. National Library of Medicine and is only available in English. Please note that we cannot guarantee a response from the person listed in the ‘Contact’ column.

NCT05199272A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies (NCT05199272)Solid Tumor, Clear Cell Renal Cell Carcinoma, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Neuroendocrine Tumors, MSI-H Cancer, Cancer With A High Tumor Mutational Burden, Extensive-stage Small-cell Lung CancerRecruiting 
NCT05488314A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer (NCT05488314)Carcinoma, Non-Small-Cell LungRecruiting 
NCT05571839A Study of SGN-BB228 in Advanced Melanoma and Other Solid Tumors (NCT05571839)Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, MesotheliomaRecruiting 
NCT05775289A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer (NCT05775289)Non-small Cell Lung CancerRecruiting 
NCT04260802A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802)Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder
NCT04449874A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874)Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid TumorsRecruiting 
NCT05538130A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130)Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal CancerRecruiting 
NCT05355701A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors. (NCT05355701)Melanoma, Colorectal Cancer, Non-Small-Cell Lung Cancer, Thyroid Cancer, GliomaRecruiting 
NCT03924869Efficacy and Safety Study of Stereotactic Body Radiotherapy (SBRT) With or Without Pembrolizumab (MK-3475) in Adults With Unresected Stage I or II Non-Small Cell Lung Cancer (NSCLC) (MK-3475-867/KEYNOTE-867) (NCT03924869)Non-Small Cell Lung CancerRecruiting 
NCT02468024JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024)Non-Small Cell Lung,
NCT02906943Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943)Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary,
NCT04335292Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer With Osimertinib Third-line Rechallenge (NCT04335292)Non-Small Cell Lung CancerRecruiting 
NCT05184712Phase 3 Clinical Study of AK112 for NSCLC Patients (NCT05184712)Non-Squamous Non-small Cell Lung CancerRecruiting 
NCT04871412The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage II (NCT04871412)Lung Cancer, Gastric Cancer, Esophageal
NCT04894591To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC) (NCT04894591)Extensive-stage Small-cell Lung CancerRecruiting 


The following research publications are pulled from PubMed using the search terms "Lung cancer" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

Unveiling the anticancer mechanism of 1,2,3-triazole-incorporated thiazole-pyrimidine-isoxazoles: insights from docking and molecular dynamics simulations.

Pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in Canada, Italy, and France: a phase 3, open-label, randomised controlled trial.

Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts.

Prediction of Acute Radiation-Induced Lung Toxicity After Stereotactic Body Radiation Therapy Using Dose-Volume Parameters From Functional Mapping on Gallium 68 Perfusion Positron Emission Tomography/Computed Tomography.

Previous Ischemic Stroke Significantly Alters Stroke Risk in Newly Diagnosed Cancer Patients.

A 20-Year Update on the Practice of Thoracic Surgery in Canada: A Survey of the Canadian Association of Thoracic Surgeons.

ctDNA response after pembrolizumab in non-small cell lung cancer: phase 2 adaptive trial results.

Appraising publicly available online resources to support patients considering decisions about medical assistance in dying in Canada: an environmental scan.

4D Monte Carlo dose reconstructions using surface motion measurements.

The Inherited KRAS-variant as a Biomarker of Cetuximab Response in NSCLC.

View more on PubMed