Ottawa Hospital Research Institute

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Lung cancer

Researchers at The Ottawa Hospital are investigating promising new approaches to prevent, diagnose and treat lung cancer. This page includes selected news stories about our lung cancer research, links to researchers working in this area and related resources.

Research News

	Reinvigorating immunotherapy: clinical trial provides new hope for lung cancer patients February 23, 2024 - The Ottawa Hospital played a key role in an international clinical trial that is providing new hope for people with advanced non-small cell lung cancer (NSCLC).
	Immunotherapy improves survival with mesothelioma lung cancer January 4, 2024 - An international clinical trial published in The Lancet shows that immunotherapy improves survival in people with an aggressive type of lung cancer called pleural mesothelioma.
	Capturing immunotherapy response in a blood drop October 26, 2023 - A clinical trial published in Nature Medicine suggests that using a “liquid biopsy” to measure tiny bits of tumour DNA in blood could determine if immunotherapy drugs are working in patients with advanced non-small cell lung cancer.
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	How a lung cancer survivor advocate is helping advance research that will lead to early detection February 7, 2020 - In September of 2013, Jill Hamer-Wilson caught something many of us tend to catch this time of year – a cold. While the cold eventually went away, a cough remained, and lingered for quite some time. Little did Jill know that this was an early sign of
	3D gel helps researchers find potential drugs for lung cancer, other diseases March 15, 2019 - Researchers in Ottawa and Toronto have created a spongy 3D gel that mimics lung tissue, allowing them to quickly screen hundreds of potential drugs for lung cancer and other diseases.
	Report suggests tobacco smoking rates will drop to below 10% in about 20 years July 17, 2018 - Ontario will achieve "single digit" tobacco smoking rates (under 10 per cent) by 2023 for women, and 2040 for men, according to a new big data report conducted jointly by the Institute for Clinical Evaluative Sciences (ICES) and The Ottawa
	Dr. Glen Goss recognized for lifetime achievement in lung cancer March 29, 2018 - Dr. Glen Goss recently received the Lifetime Achievement Award at the Canadian Lung Cancer Conference in Vancouver. This award recognizes his leadership in improving care for people with lung cancer, both as an oncologist and as a researcher. Dr. G
	Could old drugs target lung cancer in a new way? February 23, 2017 - Dr. Doug Gray received a $196,000 grant from a partnership of the Canadian Cancer Society Research Institute and Canadian Institutes of Health Research to investigate new ways to prevent lung cancer from spreading. By the time most patients with lu
	Lung cancer breakthrough: 70% of patients with specific mutation respond to new therapy November 2, 2016 - A clinical trial led by Dr. Glen Goss has helped make a new kind of personalized therapy available for some patients with non-small cell lung cancer. Over the last 15 years, many of these patients have benefited greatly from drugs that target can
	$2-million project aims to bring personalized medicine to lung cancer care October 11, 2016 - A team led by Dr. David Stewart, Dr. Bryan Lo, Dr. Pearl Campbell and Craig Ivany has received $2 million from Genome Canada and partners to develop a test that can better deliver personalized care for patients with non-small cell lung cancer. So

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Addison, Christina PhD	Senior Scientist (Cancer Therapeutics)	Bone and joint degeneration, Cancer, Lung cancer, Lung disease, Pancreatic cancer, Prostate cancer, Breast cancer	Basic research, Clinical research, Cohort studies, Disease models, Drug development, Genetics, Imaging, Model organisms, Translational research, Molecular and cellular biology
Ardolino, Michele PhD	Senior Scientist (Cancer Therapeutics)	Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma	Basic research, Cancer immunotherapy, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Gilbert, Sebastien MD FRCSC	Clinician Investigator (Clinical Epidemiology)	Cancer, Gastric cancer, Gastrointestinal disease, Gastrointestinal stromal tumours (GIST), Lung cancer, Lung disease	Artificial intelligence and data science, Clinical research, Epidemiology, Health technology, Quality Improvement
Gray, Douglas PhD	Senior Scientist Emeritus (Cancer Therapeutics)	Aging, Cancer, Lung cancer, Parkinson's	Basic research, Disease models, Genomics, Imaging, Transgenic/knockout models, Genetics, Model organisms, Molecular and cellular biology
Islam, Shahidul MD, PhD, FRCPC, FCAP	Clinician Investigator (Cancer Therapeutics)	Cancer, Endometrial cancer, Lung cancer, Ovarian cancer, Thyroid cancer
Patino, Paula MD	Clinician Investigator (Clinical Epidemiology)	Lung cancer
Ramsay, Timothy PhD	Senior Scientist (Clinical Epidemiology)	Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, Dystonia, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury	Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Stanford, William PhD	Senior Scientist (Regenerative Medicine)	Aging, Blood cancer, Cancer, COVID-19, Lung cancer, Lymphangioleiomyomatosis (LAM), Vascular, heart and metabolic disease	Artificial intelligence and data science, Molecular and cellular biology, Regenerative medicine, Stem cells, Systems biology

Related Resources

Ottawa Hospital Research Institute Cancer Therapeutics Program

The Ottawa Hospital Cancer Program

Clinical Trials

The following list of clinical trials is pulled from ClinicalTrials.gov using the search terms "Lung cancer” and “Ottawa Hospital.” More advanced search options are available. If you find a clinical trial that interests you, you can bring the information to the next appointment with your care team and ask if you are eligible for the study. If so, they may be able to refer you to the study team. Visit ohri.ca/patients to learn more about participating in research and clinical trials.

Note that ClinicalTrials.gov is hosted by the U.S. National Library of Medicine and is only available in English. Please note that we cannot guarantee a response from the person listed in the ‘Contact’ column.

NCT	Title	Condition	Status	Contact
NCT05488314	A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer (NCT05488314)	Carcinoma, Non-Small-Cell Lung	RECRUITING
NCT04895709	A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors (NCT04895709)	Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms	RECRUITING
NCT05571839	A Study of SGN-BB228 in Advanced Melanoma and Other Solid Tumors (NCT05571839)	Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, Mesothelioma	RECRUITING
NCT04260802	A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802)	Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder Cancer	RECRUITING
NCT04449874	A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874)	Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors	RECRUITING
NCT05538130	A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130)	Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer	RECRUITING
NCT05355701	A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701)	Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma	RECRUITING
NCT04609566	Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors (NCT04609566)	Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck	RECRUITING
NCT02468024	JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024)	Non-Small Cell Lung Cancer	RECRUITING	sgilbert@toh.ca; afazekas@toh.ca
NCT05714891	Neoadjuvant Platform Trial in Non-Small Cell Lung Cancer (NCT05714891)	NSCLC	RECRUITING
NCT02906943	Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943)	Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary Cancer	RECRUITING
NCT04335292	Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer With Osimertinib Third-line Rechallenge (NCT04335292)	Non-Small Cell Lung Cancer	RECRUITING
NCT05184712	Phase 3 Clinical Study of AK112 for NSCLC Patients (NCT05184712)	Non-Squamous Non-small Cell Lung Cancer	RECRUITING
NCT04093167	Study of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC (NCT04093167)	Non-Small Cell Lung Cancer	RECRUITING
NCT04871412	The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage II (NCT04871412)	Lung Cancer, Gastric Cancer, Esophageal Cancer	RECRUITING
NCT04894591	To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC) (NCT04894591)	Extensive-stage Small-cell Lung Cancer	RECRUITING

Publications

The following research publications are pulled from PubMed using the search terms "Lung cancer" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

Epidemiology of Cancer in Kidney Transplant Recipients.
2024-03-28

Population Survival Kinetics Derived from Clinical Trials of Potentially Curable Lung Cancers.
2024-03-27

Involvement of Palliative Care in Malignant Pleural Mesothelioma Patients and Associations with Survival and End-of-Life Outcomes.
2024-02-23

Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial.
2024-02-14

Decision aids for people facing health treatment or screening decisions.
2024-01-29

Prognostic significance of lymph nodes assessment during pulmonary metastasectomy: a systematic review and meta-analysis.
2024-01-22

FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models.
2024-01-09

2023 Canadian Surgery Forum: Sept. 20-23, 2023.
2024-01-04

Internal Standards for Limit Controls and Absolute Abundance Measurement of Oncogenic Fusions and Mutations.
2024-01-04

Canadian Consensus Recommendations for the Management of Operable Stage II/III Non-Small-Cell Lung Cancer: Results of a Modified Delphi Process.
2023-12-22

View more on PubMed