Ottawa Hospital Research Institute

Pulmonary hypertension

The Ottawa Hospital is conducting cutting-edge research to improve our understanding of pulmonary hypertension and develop better approaches for treatment and prevention. This page includes selected news stories about our pulmonary hypertension research, links to researchers working in this area and related resources. Learn more below.

Research News

	Pioneering biotherapeutics trial paves the way for innovative approaches to treat pulmonary arterial hypertension June 20, 2025 - Pulmonary arterial hypertension (PAH) is a rare and deadly disease that involves progressive damage to the tiny blood vessels that feed the lungs. In most cases, the cause is unknown and treatments are limited.
	Researchers at The Ottawa Hospital awarded three grants for high risk, high reward and interdisciplinary research June 18, 2024 - The New Frontiers in Research Fund (NFRF) 2023 Exploration competition has awarded $33 million to support 133 research teams across Canada that bring diverse disciplines together in pursuit of breakthrough ideas and high-reward outcomes.
	Study could lead to new treatments for pulmonary hypertension and right heart failure February 28, 2023 - The human heart has a remarkable ability to adapt and compensate in the face of injury and disease, but unfortunately this isn’t universal.
Show more news stories
	Tiny particles hold promise for treating acute and chronic lung disease February 17, 2022 - A meta-analysis of lab studies found that tiny particles called extracellular vesicles (EVs) released by mesenchymal stem/stromal cells (MSCs) have clear potential for treating acute lung injury,
	New research could explain why cells grow out of control in rare lung disease May 9, 2018 - When cells grow out of control in the body, most people think of cancer, but this phenomenon also occurs in pulmonary arterial hypertension (PAH), a rare and deadly disease characterized by very high pressure in the arteries that supply blood to th
	Experimental stem cell therapy tested for rare lung disease April 30, 2018 - A Canadian-led research team has launched a clinical trial of an experimental stem cell therapy for pulmonary arterial hypertension. This rare and deadly disease occurs when the arteries that supply blood to the lungs become so damaged that blood can
	How to trick your heart into thinking you exercise: cardiotrophin improves heart health and repairs damage in lab models August 4, 2017 - Researchers have discovered that a protein called cardiotrophin 1 (CT1) can trick the heart into growing in a healthy way and pumping more blood, just as it does in response to exercise and pregnancy. They show that this good kind of heart growth i
	Researchers get $558K boost from Heart and Stroke Foundation June 15, 2017 - Two scientists from The Ottawa Hospital and the University of Ottawa were successful in the Heart and Stroke Foundation’s recent grant-in-aid grant competition. Dr. Baptiste Lacoste was awarded $259,000* to test whether drugs that are already used
	Stem cell therapy shows promise in small clinical trial for rare lung disease July 20, 2015 - Canadian researchers have published promising results of the first clinical trial in the world of a genetically-enhanced stem cell therapy for pulmonary arterial hypertension (PAH). This rare and deadly disease mainly affects young women, and i

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Ramsay, Timothy PhD	Senior Scientist (Methodological and Implementation Research)	Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury	Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Stewart, Duncan MD, FRCPC	Senior Scientist (Regenerative Medicine)	COVID-19, Heart disease, Pulmonary hypertension, Septic shock, Vascular, heart and metabolic disease	Extracellular vesicles / exosomes, Stem cells, Cell therapy, Clinical trials, Molecular and cellular biology, Regenerative medicine, Translational research

Related Resources

Search for clinical trials at The Ottawa Hospital related to this disease or condition.