Ottawa Hospital Research Institute

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Septic shock

Septic shock is a life-threatening condition that can occur when an infection spreads throughout the body. Researchers at The Ottawa Hospital are leading cutting-edge studies to improve our understanding of septic shock and develop better treatments. This page includes selected news stories about our septic shock research, links to researchers working in this area and related resources. Learn more below.

Research News

	ELEVATE seed grants to help researchers at The Ottawa Hospital improve treatment for inflammatory and immune conditions February 21, 2024 - The Ottawa Hospital’s Research Institute is awarding four ELEVATE seed grants to help researchers understand the role of inflammation and the immune system in various diseases and develop better treatments.
	Moving the needle forward on sepsis research with a world-first clinical trial March 16, 2023 - The search for the silver bullet for sepsis has been decades in the making. However, The Ottawa Hospital is taking a big step forward in the next phase of a world-first clinical trial using stem cells in patients with septic shock.
	Meet Dr. Manoj Lalu, the clinician-scientist bringing lab discoveries to patients every day March 16, 2023 - From looking at how we can use stem cells to treat diseases like sepsis to dealing with patients directly in the ICU and OR, Dr. Lalu is making an impact behind the scenes and beyond.
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	Meet Dr. Lauralyn McIntyre — sepsis researcher and clinician extraordinaire March 16, 2023 - Dr. Lauralyn McIntyre’s path to The Ottawa Hospital wasn’t necessarily a direct one — it took her all over Ontario and out west to the mountains — but she couldn’t do her groundbreaking sepsis research anywhere else, or with any other team.
	Clinical trial will test promising cell therapy for septic shock January 19, 2023 - Dr. Lauralyn McIntyre was awarded $1.6 million from the Canadian Institutes of Health Research Clinical Trials Fund to conduct a Phase II clinical trial of mesenchymal stem cells (MSCs) in patients with septic shock.
	Intravenous vitamin C treatment does not help sepsis patients December 14, 2022 - A randomized controlled trial published in the New England Journal of Medicine has quashed the theory that intravenous vitamin C could prevent death and organ damage in patients with sepsis.
	Researchers at The Ottawa Hospital awarded 19 CIHR grants worth more than $12 million July 20, 2022 - These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, muscle
	Ottawa Hospital researchers awarded $1.85M from Stem Cell Network May 12, 2022 - Four research teams at The Ottawa Hospital have been awarded a total of $1.85 million to harness stem cells and regenerative medicine to develop new therapies for septic shock, bone and joint conditions, and newborn lung damage, while also advancing
	Biomanufacturing partnership boosts Canada’s life-saving treatment and vaccine capacity September 13, 2021 - As Canada seeks to rebuild its biomanufacturing sector and support made-in-Canada solutions to global health challenges, The Ottawa Hospital, the University of Alberta and BioCanRx have collaborated to create Canada’s first full-service, end-to-end b
	Researchers at The Ottawa Hospital awarded three grants for high risk, high reward and interdisciplinary research May 31, 2021 - The New Frontiers in Research Fund (NFRF) 2020 Exploration competition brings diverse disciplines together in pursuit of breakthrough ideas and high-reward outcomes.
	Sepsis costs Ontario healthcare system $1 billion per year February 22, 2021 - A study published in Critical Care Medicine led by researchers at The Ottawa Hospital, the University of Ottawa, and ICES shows that severe sepsis is linked with higher mortality, increased hospital readmission and higher healthcare costs. In Ontario
	The Ottawa Hospital awarded six CIHR grants worth $2.6 million September 7, 2020 - Could a common diabetes drug help prevent ovarian cancer? Can a tailored screening program help prevent eye disease in immigrants? Is sepsis different in females versus males, and if so, can this help us develop better treatments? These are just a fe
	$950,000 to help develop stem cell treatments for septic shock, lung injury and muscle degeneration May 17, 2019 - Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks to four new peer-reviewed research grants from the Ontario Institute for Regenerative Medici
	New scientist profile: Dr. Kwadwo Kyeremanteng aims to improve care for the critically ill September 25, 2018 - As a critical care and palliative care physician at The Ottawa Hospital, Dr. Kwadwo Kyeremanteng cares for the sickest of the sick patients in the intensive care unit (ICU). As a researcher, he’s interested in using ICU resources more efficiently an
	$870,000 to help develop stem cell treatments for septic shock, glaucoma, lung injury and muscle degeneration May 9, 2018 - Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks to five new peer-reviewed research grants from the Ontario Institute for Regenerative Medi
	Could stem cells repair the heart, fight infections, mend premature lungs, and heal the brain after stroke? April 11, 2018 - Ottawa researchers closer to finding out, thanks to $999,900 from the Stem Cell Network Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks
	Stem cells for septic shock: world-first trial establishes safety, sets stage for larger trial November 2, 2017 - Stem cells are usually thought of as the building blocks of the body – able to give rise to all our cells and organs. But Dr. Lauralyn McIntyre, Dr. Duncan Stewart, Dr. Dean Fergusson and their colleagues are testing the idea that certain stem cells
	New treatment for our sickest patients comes closer to reality June 30, 2017 - The Ottawa Hospital was one of the top sites for enrolling patients in an international clinical trial of a promising new treatment for shock. The study, published in the New England Journal of Medicine, shows that a naturally-occurring protein calle
	Could stem cells heal premature lungs, fight infections, build muscles and strengthen bones? May 25, 2017 - Ottawa researchers closer to finding out, thanks to $1.5 million from the Ontario Institute for Regenerative Medicine Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to huma
	The Ottawa Hospital awarded 18 research grants from the Canadian Institutes of Health Research, worth $10.7 million May 19, 2017 - Eighteen research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded nearly $11 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). This represents a suc

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Clark, Edward MD MSc FRCPC	Associate Scientist (Clinical Epidemiology)	Kidney disease, Septic shock	Clinical research, Clinical trials, Epidemiology
English, Shane MD	Senior Scientist (Clinical Epidemiology)	COVID-19, Septic shock, Subarachnoid hemorrhage, Traumatic brain injury	Clinical research, Critical care, Patient engagement
Fergusson, Dean PhD, MHA, FCAHS	Program Director and Senior Scientist (Clinical Epidemiology)	Cancer, COVID-19, Kidney disease, Septic shock, Vascular, heart and metabolic disease	Clinical trials, Health services research, Health technology, Patient engagement, Pragmatic trials, Surveys, Translational research, Biostatistics, Clinical research, Cluster randomized trials, Cohort studies, Critical care, Health research methods, Qualitative methods, Quality Improvement, Systematic reviews, Transfusions
Maqsood, Muhammad MD	Clinician Investigator (Chronic Disease)	Newborn and child health, Septic shock
McIntyre, Lauralyn MD, MHSc, FRCPC	Senior Scientist (Clinical Epidemiology)	Septic shock	Cell therapy, Clinical research, Clinical trials, Critical care, Patient engagement, Pragmatic trials, Stem cells, Transfusions, Translational research
Mei, Shirley PhD, MSc	Investigator (Regenerative Medicine)	COVID-19, Septic shock	Basic research, Biomarkers, Cell therapy, Critical care, Disease models, Epigenetics, Gene therapy, Knowledge translation and implementation research, Molecular and cellular biology, Regenerative medicine, Stem cells
Ramsay, Timothy PhD	Senior Scientist (Clinical Epidemiology)	Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, Dystonia, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury	Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Stewart, Duncan MD, FRCPC	Senior Scientist (Regenerative Medicine)	COVID-19, Heart disease, Pulmonary hypertension, Septic shock, Vascular, heart and metabolic disease	Extracellular vesicles / exosomes, Stem cells, Cell therapy, Clinical trials, Molecular and cellular biology, Regenerative medicine, Translational research
Thavorn, Kednapa BPharm, MPharm, PhD	Senior Scientist (Clinical Epidemiology)	Cancer, COVID-19, Diabetes, Gastrointestinal disease, Glaucoma, Global health, Health equity, Health in disadvantaged peoples, Health in older peoples, HIV, Immigrant and refugee health, Population health, Septic shock, Stroke, Thrombosis / thromboembolism, Vision	Clinical research, Cohort studies, Epidemiology, Health economics, Health research methods, Health services research, Knowledge translation and implementation research, Patient engagement, Pharmacy, Public health, Quality Improvement, Systematic reviews

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