Ottawa Hospital Research Institute

Research News

	When the hangman isn't hanging: how cell death proteins might protect against ALS August 18, 2023 - For more than 30 years, caspases have been known as tiny cellular executioners, just waiting for a signal to chop up a cell’s proteins and initiate what is known as “programmed cell death.”
	Melding mind and machine: Ottawa trial could lead to new technologies to help people with paralysis June 16, 2021 - Researchers at The Ottawa Hospital and the University of Ottawa are launching a world-first clinical trial that could lead to a new kind of brain computer interface, paving the way for advanced technologies to help people with paralysis.
	The Ottawa Hospital opens one-of-a-kind neuromuscular research centre May 1, 2018 - You can help!The Ottawa Hospital needs crucial equipment for neuromuscular research, including:An ultracentrifuge that separates cells into different components by spinning themat very high speed.This crucial piece of equipment can exert a force that
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	New worm model sheds light on ALS October 11, 2017 - Dr. Johnny Ngsee’s team has created the first worm model of a genetic form of ALS called ALS8 that can be used to learn more about the disease and test possible therapies. ALS, or Amyotrophic Lateral Sclerosis, is caused by the gradual death of the

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Chakraborty, Santanu MBBS, MRCP, DMRD, FRCR, FRCP(C)	Senior Clinician Investigator (NS)	Amyotrophic lateral sclerosis, Brain cancer, Concussion, Dementia, Head and neck cancer, Multiple sclerosis, Parkinson's, Spinal cord injury, Stroke, Traumatic brain injury	Bioinformatics, Clinical research, Health economics, Health professional behaviour change, Imaging, Immunization, Patient safety, Quality Improvement, Risk assessment
Kothary, Rashmi Ph.D.	Senior Scientist (RM)	Neuromuscular disease, Amyotrophic lateral sclerosis, Multiple sclerosis, Muscular dystrophy, Spinal muscular atrophy	Basic research, Disease models, Drug development, Epigenetics, Epigenetics, Gene therapy, Genetics, Imaging, Lipidomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Transgenic/knockout models, Translational research
Mestre, Tiago MSc MD	Scientist (NS)	Amyotrophic lateral sclerosis, Huntington's, Parkinson's	Clinical trials, Imaging
Ngsee, John Ph.D.	Affiliate Investigator (NS)	Amyotrophic lateral sclerosis, Dementia, Parkinson's	Cell therapy, Drug development, Model organisms, Molecular and cellular biology
Ramsay, Timothy PhD	Senior Scientist (MIR)	Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury	Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Sachs, Adam MD, MA, FRCSC	Associate Scientist (NS)	Amyotrophic lateral sclerosis, Spinal cord injury, Parkinson's	Artificial intelligence and data science, Clinical trials, Imaging, Neuro-stimulation, Surgery
Warman Chardon, Jodi MD, PhD FRCPC (Neurology)	Associate Scientist (NS)	Amyotrophic lateral sclerosis, Genetic myopathy, Muscular dystrophy, Neuromuscular disease, Spinal muscular atrophy, Stiff person syndrome	Artificial intelligence and data science, Clinical research, Clinical trials, Exome sequencing analysis, Genetics, Imaging, MRI muscle imaging, Next generation sequencing, RNA sequencing, Genetics

Related Resources

Neuroscience Program at the Ottawa Hospital Research Institute

Search for clinical trials at The Ottawa Hospital related to this disease or condition.

Publications

The following research publications are pulled from PubMed using the search terms "Amyotrophic lateral sclerosis" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

A stress-dependent TDP-43 SUMOylation program preserves neuronal function.
2025-03-28

Qualitative Analysis of Initial Palliative Care Consultations in Amyotrophic Lateral Sclerosis.
2024-07-01

Neurofilaments as biomarkers in neurological disorders - towards clinical application.
2024-05-01

Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth.
2023-10-31

A Randomized Controlled Clinical Trial of Lung Volume Recruitment in Adults with Neuromuscular Disease.
2023-10-01

Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates.
2023-08-07

Respiratory Management of Patients With Neuromuscular Weakness: An American College of Chest Physicians Clinical Practice Guideline and Expert Panel Report.
2023-08-01

Systematic overviews of partnership principles and strategies identified from health research about spinal cord injury and related health conditions: A scoping review.
2023-07-01

Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function.
2023-05-01

Motor Band Sign in Motor Neuron Disease: A Marker for Upper Motor Neuron Involvement.
2023-05-01

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