Transgenic/knockout models

Research News


Lab-grown “mini-kidneys” unlock secrets of a rare disease Lab-grown “mini-kidneys” unlock secrets of a rare disease
July 21, 2022 - Researchers have solved a medical mystery in a poorly understood disease by uncovering which cells cause tumours in patients with tuberous sclerosis complex (TSC).
Nerve cell structure plays a major role in kidney function Nerve cell structure plays a major role in kidney function
July 24, 2018 - Dr. Chris Kennedy’s team has found that the nervous system controls how quickly the kidneys filter blood, and one protein is essential to this process. In the first study of its kind, the team found that a lack of the protein ubiquitin C-terminal hyd


Researchers


Name Scientific appointment Diseases, conditions and populations of interest Research and clinical approaches
Albert, Paul
PhD
Senior Scientist
(Neuroscience) 		Mental health, Vascular cognitive impairment, Anxiety, Depression, Intellectual disabilities, Parkinson's, Schizophrenia, Stroke, Suicide Basic research, Epigenetics, Exercise, Gene expression, Translational research, Disease models, Epigenetics, Genetics, Imaging, Molecular and cellular biology, Optogenetics, Transgenic/knockout models
Ardolino, Michele
PhD
Senior Scientist
(Cancer Research) 		Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma Basic research, Cancer immunotherapy, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Brand, Marjorie
PhD
Senior Scientist Affiliate
(Regenerative Medicine) 		Blood cancer, Sickle cell anemia, Thalassemia, Vascular, heart and metabolic disease Artificial intelligence and data science, Basic research, Bioinformatics, Disease models, Epigenetics, Gene expression, Genomics, Imaging, Model organisms, Molecular and cellular biology, Proteomics, Stem cells, Systems biology, Transgenic/knockout models
Burger, Dylan
PhD
Senior Scientist
(Inflammation and Chronic Disease) 		Aging, Diabetes, Heart disease, Hypertension, Kidney disease, Maternal and fetal health, Obesity, Thrombosis / thromboembolism, Type 1 diabetes, Vascular cognitive impairment, Vascular, heart and metabolic disease Basic research, Biomarkers, Disease models, Exercise, Extracellular vesicles / exosomes, Imaging, Model organisms, Molecular and cellular biology, Pharmacology, Proteomics, Regenerative medicine, Stem cells, Transgenic/knockout models, Translational research
Burns, Kevin
MD CM, FRCPC
Senior Scientist
(Inflammation and Chronic Disease) 		Diabetes, Kidney disease, Vascular, heart and metabolic disease Basic research, Biomarkers, Cell therapy, Clinical research, Disease models, Extracellular vesicles / exosomes, Gene expression, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models, Translational research
Chen, Hsiao-Huei
PhD
Senior Scientist
(Neuroscience) 		Aging, Autism, Dementia, Depression, Heart disease, Maternal and fetal health, Mental health, Tourette's, Alzheimer's, Alzheimer's, Anxiety, Diabetes, Obesity, Schizophrenia, Stroke, Vascular, heart and metabolic disease Disease models, Drug development, Gene expression, Neuro-stimulation, Optogenetics, Transgenic/knockout models, Basic research, Molecular and cellular biology, Translational research
Coutu, Daniel
PhD
Scientist
(Regenerative Medicine) 		Aging, Arthritis, Autoimmune disease, Bleeding disorders, Blood cancer, Bone and joint degeneration, Bone and joint injuries, Musculoskeletal conditions, Osteoporosis Basic research, Bioinformatics, Biomaterials, Cell therapy, Gene expression, Gene therapy, Genetics, Genomics, Imaging, Immunotherapy, Molecular and cellular biology, Proteomics, Regenerative medicine, Stem cells, Surgery, Systems biology, Transgenic/knockout models, Translational research
Gray, Douglas
PhD
Senior Scientist Emeritus
(Cancer Research) 		Aging, Cancer, Lung cancer, Parkinson's Basic research, Disease models, Genomics, Imaging, Transgenic/knockout models, Genetics, Model organisms, Molecular and cellular biology
Habibi, Ehsan
Ph.D.
Scientist
(Regenerative Medicine) 		Artificial intelligence and data science, Basic research, Big data, Bioinformatics, Epigenetics, Gene expression, Genetics, Imaging, Model organisms, Molecular and cellular biology, Next generation sequencing, Optogenetics, Proteomics, Qualitative methods, RNA sequencing, Systems biology, Transgenic/knockout models
Kothary, Rashmi
Ph.D.
Senior Scientist
(Regenerative Medicine) 		Neuromuscular disease, Amyotrophic lateral sclerosis, Multiple sclerosis, Muscular dystrophy, Spinal muscular atrophy Basic research, Disease models, Drug development, Epigenetics, Epigenetics, Gene therapy, Genetics, Imaging, Lipidomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Transgenic/knockout models, Translational research
Lacoste, Baptiste
PhD
Senior Scientist
(Regenerative Medicine) 		Stroke, Vascular cognitive impairment, Autism Basic research, Disease models, Gene expression, Genomics, Stem cells, Genetics, Imaging, Model organisms, Molecular and cellular biology, Transgenic/knockout models
Mattar, Pierre
PhD
Senior Scientist
(Regenerative Medicine) 		Autism, Autoimmune diseases of the nervous system, Glaucoma, Intellectual disabilities, Macular degeneration, Retinal disease, Vision Basic research, Bioinformatics, Cell therapy, Epigenetics, Gene expression, Genetics, Genomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Stem cells, Systems biology, Transgenic/knockout models
McBurney, Michael
PhD
Program Director and
Senior Scientist Emeritus
(Cancer Research) 		Aging, Diabetes, Cancer Molecular and cellular biology, Transgenic/knockout models, Basic research
Picketts, David
Ph.D.
Senior Scientist
(Regenerative Medicine) 		Autism, Brain and neuromuscular disease, Intellectual disabilities, Multiple sclerosis, Stroke, Vision Basic research, Disease models, Epigenetics, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models
Rudnicki, Michael
OC, PhD, FRS, FRSC
Program Director and
Senior Scientist
(Regenerative Medicine) 		Muscular dystrophy, Neuromuscular disease Basic research, Bioinformatics, Disease models, Epigenetics, Genetics, Genomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Stem cells, Transgenic/knockout models
Sabourin, Luc
PhD
Senior Scientist
(Cancer Research) 		Breast cancer, Muscular dystrophy, Skin cancer Basic research, Disease models, Drug development, Gene expression, Genetics, Molecular and cellular biology, Proteomics, Stem cells, Transgenic/knockout models
Schlossmacher, Michael
MD, DABPN, FRCPC
Program Director and
Senior Scientist
(Neuroscience) 		Aging, Brain and neuromuscular disease, Crohn's, Dementia, Inflammatory bowel syndrome, Dementia, Parkinson's Basic research, Biomarkers, Cohort studies, Disease models, Drug development, Genetics, Lipidomics, Molecular and cellular biology, Proteomics, Risk assessment, Transgenic/knockout models, Translational research
Vanderhyden, Barbara
PhD
Senior Scientist
(Cancer Research) 		Cancer, Infertility, Ovarian cancer, Women's health Basic research, Bioinformatics, Biomarkers, Cancer biotherapeutics, Disease models, Drug development, Epigenetics, Gene expression, Genomics, Immunotherapy, Model organisms, Molecular and cellular biology, Oncolytic viruses, Stem cells, Transgenic/knockout models, Translational research, Viral therapy
Wang, Jing
Ph.D.
Senior Scientist
(Regenerative Medicine) 		Alzheimer's, Multiple sclerosis, Stroke Cell therapy, Disease models, Epigenetics, Imaging, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models