David Picketts

David Picketts

Ph.D.

Senior Scientist, Regenerative Medicine

Ottawa Hospital Research Institute

Deputy Scientific Director, Basic Science

Ottawa Hospital Research Institute

Professor, Department of Medicine, Department of Biochemistry, Microbiology and Immunology and Department of Cellular and Molecular Medicine

University of Ottawa

Contact

613-737-8989

Heidi Hickey (Research Administrative Assistant) 613-737-8899 x72794, hhickey@ohri.ca

Research Groups

Research Group
Picketts Lab
Epigenetic Regulation in Brain Development and Disease Pathology Disease gene identification for neurodevelopmental disorders has demonstrated tha...

Bio

Dr. Picketts completed a PhD at Queen's University (Kingston) in 1993 with Dr. David Lillicrap studying Hemophilia B and the transcriptional regulation of the Factor IX gene. He then pursued postdoctoral research in Oxford, England with Dr. Douglas Higgs at the Weatherall Institute of Molecular Medicine. Here he began studies with a clinical research fellow, Dr. Richard Gibbons to identify the causative gene of the ATR-X syndrome, a severe neurodevelopmental disorder. In 1995, they identified the ATRX gene establishing the paradigm that dysfunctional chromatin remodeling proteins cause human disease. In 1997, Dr. Picketts joined the OHRI as an independent investigator to continue defining the role of epigenetic regulators in brain development and intellectual disability disorders. In his spare time, Dr. Picketts is an avid ice hockey enthusiast, playing several times a week. He is a former member of the Oxford Ice Hockey Team and devoted 18 years to the Russell Minor Hockey Association as both a coach and a board member. Dr. Picketts has three grown children and resides with his wife of 30 years on a small hobby farm south of Ottawa.


News


Publications

Interferon dependent immune memory during HSV-1 neuronal latency via increased H3K9me3 and restriction by ATRX

2025-12-01 Go to publication

The SMARCA5–DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development

2025-10-08 Go to publication

It Takes a Village of Chromatin Remodelers to Regulate rDNA Expression

2025-02-19 Go to publication

The chromatin remodeler ADNP regulates neurodevelopmental disorder risk genes and neocortical neurogenesis

2025-01-21 Go to publication

PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS

2024-01-01

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