Ottawa Hospital Research Institute

Research News

	Can a blood test predict if MS attacks will come back after stopping treatment? March 15, 2024 - Some people prefer to stop immune-suppressing treatment if their disease has been stable for years, but there’s no way to know whether their symptoms will return.
	Capturing immunotherapy response in a blood drop October 26, 2023 - A clinical trial published in Nature Medicine suggests that using a “liquid biopsy” to measure tiny bits of tumour DNA in blood could determine if immunotherapy drugs are working in patients with advanced non-small cell lung cancer.
	The Ottawa Hospital Joins Michael J. Fox Foundation’s Expansion of the Parkinson’s Progression Markers Initiative (PPMI), Landmark Study toward Better Treatments and Prevention of Disease March 3, 2022 - The Ottawa Hospital aims to enroll people recently diagnosed with Parkinson’s who are not yet taking medication and individuals over age 60 with certain risk factors in the Parkinson’s Progression Markers Initiative (PPMI),
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	Researcher blazes a trail in ovarian cancer November 12, 2021 - Dr. Meshach Asare-Werehene is receiving the Worton Researcher in Training Award from The Ottawa Hospital in recognition of his cutting-edge discoveries and extraordinary leadership
	Tiny bits of blood vessel may warn of newborn complications November 4, 2021 - A study published in Biomarker Research co-led by Drs. Dylan Burger and Denice Feig found that extracellular vesicles may be able to predict newborn outcomes, at least in pregnant people with diabetes.
	Does Parkinson’s start in the nose? International team awarded US$9 million ASAP grant to find out October 26, 2021 - More than 80 percent of people with Parkinson’s disease suffer from a reduced sense of smell, something that often occurs years before the onset of typical movement-related symptoms. Now, thanks to a US$9 million grant from the Aligning Science Acros
	New scientist profile: Dr. Angela Cheung’s patients inspire her to investigate rare liver diseases January 27, 2021 - Dr. Angela Cheung understands why her patients with autoimmune liver diseases are frustrated. Little is known about these rare diseases, and treatments can often only delay, but not prevent, a liver transplant.
	Acute kidney injury and chronic kidney disease— newfound hope for treatment September 12, 2019 - Researchers at The Ottawa Hospital are working together to help prevent and treat acute kidney injury and chronic kidney disease.
	Researchers discover new kind of brain tumour July 8, 2019 - Dr. John Woulfe and his colleagues have identified a new kind of brain tumour. It was removed during a young woman’s treatment, and did not match any existing tumour classifications.
	Precision medicine approach for leukemia awarded $1.5M May 1, 2019 - Acute myeloid leukemia (AML) is one of the deadliest forms of cancer. A team of researchers from The Ottawa Hospital and uOttawa is hoping to revolutionize treatment for AML by developing a “precision medicine” approach.
	Simple blood test could determine preterm birth rate in low resource countries March 19, 2019 - Preterm birth is a leading cause of death among children under the age of five, with low resource countries facing the greatest challenge. But before solutions c­­an be tested­­, researchers first need to be able to accurately mea
	New scientist profile: Dr. Hanns Lochmüller investigates rare neuromuscular disorders March 15, 2019 - Dr. Hanns Lochmüller, a neurologist and senior scientist recently recruited to CHEO Research Institute from the U.K., has now also been appointed as an associate scientist in the Neuroscience Program at the Ottawa Hospital Research Institute.
	New drug combination destroys chemo-resistant blood cancer October 22, 2018 - Researchers from The Ottawa Hospital and the University of Ottawa have developed a promising targeted strategy to treat chemotherapy-resistant acute myeloid leukemia (AML) and a diagnostic test to determine which AML patients would most likely benefi
	Using big data to help the smallest babies – Canadian researchers use newborn blood tests to identify preterm children in low-resource countries March 23, 2018 - Researchers from The Ottawa Hospital, the Children’s Hospital of Eastern Ontario and the University of Ottawa have received nearly US $1 million from the Bill & Melinda Gates Foundation to find out how often babies are born preterm in low-resource co
	Lung cancer breakthrough: 70% of patients with specific mutation respond to new therapy November 2, 2016 - A clinical trial led by Dr. Glen Goss has helped make a new kind of personalized therapy available for some patients with non-small cell lung cancer. Over the last 15 years, many of these patients have benefited greatly from drugs that target can
	$2-million project aims to bring personalized medicine to lung cancer care October 11, 2016 - A team led by Dr. David Stewart, Dr. Bryan Lo, Dr. Pearl Campbell and Craig Ivany has received $2 million from Genome Canada and partners to develop a test that can better deliver personalized care for patients with non-small cell lung cancer. So

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Aviv, Richard MBChB, FRCR (UK), FRCPC, dABR	Clinician Investigator (Neuroscience)	Brain and neuromuscular disease, Brain cancer, Head and neck cancer, Multiple sclerosis, Stroke, Subarachnoid hemorrhage, Traumatic brain injury, Vascular cognitive impairment, Vascular, heart and metabolic disease	Artificial intelligence and data science, Basic research, Big data, Bioinformatics, Biomarkers, Clinical research, Cluster randomized trials, Disease models, Health economics, Health technology, Imaging, Patient safety, Quality Improvement, Translational research
Berardi, Philip MD, PhD, FRCPC	Clinician Investigator (Cancer Research)	Aging, Anemia, Bleeding disorders, Blood cancer, Cancer, COVID-19, Health equity, Health in older peoples, Sickle cell anemia, Thalassemia, Thrombosis / thromboembolism	Artificial intelligence and data science, Basic research, Bioinformatics, Biomarkers, Cancer biotherapeutics, Cell therapy, Epigenetics, Gene expression, Genetics, Genomics, Immunotherapy, Molecular and cellular biology, Stem cells, Translational research
Bose, Gauruv MD, FRCPC	Associate Scientist (Neuroscience)	Autoimmune diseases of the nervous system, Multiple sclerosis	Artificial intelligence and data science, Biomarkers, Clinical decision rules, Clinical trials, Cohort studies, Health economics
Burger, Dylan PhD	Senior Scientist (Inflammation and Chronic Disease)	Aging, Diabetes, Heart disease, Hypertension, Kidney disease, Maternal and fetal health, Obesity, Thrombosis / thromboembolism, Type 1 diabetes, Vascular cognitive impairment, Vascular, heart and metabolic disease	Basic research, Biomarkers, Disease models, Exercise, Extracellular vesicles / exosomes, Imaging, Model organisms, Molecular and cellular biology, Pharmacology, Proteomics, Regenerative medicine, Stem cells, Transgenic/knockout models, Translational research
Burns, Kevin MD CM, FRCPC	Senior Scientist (Inflammation and Chronic Disease)	Diabetes, Kidney disease, Vascular, heart and metabolic disease	Basic research, Biomarkers, Cell therapy, Clinical research, Disease models, Extracellular vesicles / exosomes, Gene expression, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models, Translational research
Cook, David PhD	Scientist (Cancer Research)	Cancer, Ovarian cancer	Artificial intelligence and data science, Basic research, Big data, Bioinformatics, Biomarkers, Cancer biotherapeutics, Cancer immunotherapy, Cell therapy, Drug development, Epigenetics, Gene expression, Genomics, Imaging, Immunotherapy, Molecular and cellular biology, RNA sequencing, Systems biology, Translational research
Dargel, Aroldo M.D., Ph.D.	Associate Scientist (Neuroscience)	Anxiety, Bipolar, Dementia, Depression, Diabetes, Hypertension, Mental health, Obesity, Population health, Suicide, Vascular, heart and metabolic disease	Artificial intelligence and data science, Behaviour, Big data, Biomarkers, Biostatistics, Clinical research, Clinical trials, Digital and mobile health, Epidemiology, Health technology, Prevention, Psychology, Quality Improvement, Rapid reviews, Systematic reviews, Translational research
Dennis, Kristopher MD FRCPC PhD	Clinician Investigator (Cancer Research)	Cancer, Colorectal cancer, Gastric cancer, Liver cancer, Pain, Pancreatic cancer	Behaviour, Biomarkers, Clinical research, Clinical trials, Cohort studies, Health professional behaviour change, Health services research, Palliative care, Pragmatic trials, Qualitative methods, Quality Improvement, Systematic reviews
Fadda, Giulia MD	Associate Scientist (Neuroscience)	Autoimmune diseases of the nervous system, Multiple sclerosis	Bioinformatics, Biomarkers, Biostatistics, Clinical research, Imaging, Immunotherapy, Molecular and cellular biology, Patient engagement, Translational research
Hawken, Steven PhD	Senior Scientist (Methodological and Implementation Research)	Population health, Global health, Newborn and child health, Pregnancy	Artificial intelligence and data science, Big data, Biomarkers, Health services research, Immunization, Biostatistics, Epidemiology, Health research methods
Hundemer, Gregory MD, MPH	Scientist (Inflammation and Chronic Disease)	Heart disease, Hypertension, Kidney disease, Vascular, heart and metabolic disease	Biomarkers, Clinical research, Cohort studies
Ito, Caryn PhD	Senior Investigator (Regenerative Medicine)	Blood cancer, Cancer	Basic research, Bioinformatics, Biomarkers, Drug development, Epigenetics, Molecular and cellular biology, Proteomics, Regenerative medicine, Stem cells, Systems biology, Translational research
Klein, Ran PhD	Clinician Investigator (Methodological and Implementation Research)	Cancer, Heart disease, Kidney disease, Lung disease, Vascular, heart and metabolic disease	Artificial intelligence and data science, Basic research, Bioinformatics, Biomarkers, Biostatistics, Clinical decision rules, Health technology, Imaging
Mei, Shirley PhD, MSc	Investigator (Regenerative Medicine)	COVID-19, Infectious disease, Influenza, Lung disease, Septic shock	Basic research, Biomarkers, Cell therapy, Critical care, Disease models, Drug development, Epigenetics, Gene therapy, Knowledge translation and implementation research, Molecular and cellular biology, Regenerative medicine, Stem cells, Translational research
Morgan, Scott MD, MSc, FRCPC	Clinician Investigator (Cancer Research)	Bladder cancer, Breast cancer, Cancer, Prostate cancer	Biomarkers, Clinical research, Clinical trials, Cohort studies, Imaging, Systematic reviews
Nessim, Carolyn MD, MSc, FRCSC, FACS	Clinician Investigator (Cancer Research)	Cancer, Colorectal cancer, Gastric cancer, Gastrointestinal disease, Gastrointestinal stromal tumours (GIST), Soft tissue sarcoma, Skin cancer	Biomarkers, Clinical trials, Gene expression, Immunotherapy, Surgery, Translational research, Viral therapy, Clinical research, Immunotherapy
Perkins, Theodore PhD	Senior Scientist (Regenerative Medicine)	Brain and neuromuscular disease, Cancer, Muscular dystrophy, Musculoskeletal conditions, Neuromuscular disease	Artificial intelligence and data science, Basic research, Big data, Bioinformatics, Biomarkers, Biostatistics, Epigenetics, Gene expression, Genetics, Genomics, Proteomics, Regenerative medicine, Stem cells, Systems biology, Translational research
Poulin, Patricia C. Psych.	Associate Scientist (Neuroscience)	Addiction, Anxiety, Cancer, Chronic pain, Depression, Health equity, Musculoskeletal conditions, Pain	Anesthesiology, Behaviour, Biomarkers, Clinical research, Clinical trials, Emergency medicine, Epidemiology, Health professional behaviour change, Health services research, Knowledge translation and implementation research, Palliative care, Patient decision aids, Patient safety, Peri-operative medicine, Pragmatic trials, Psychology, Qualitative methods, Quality Improvement, Systematic reviews
Sabloff, Mitchell MSc, MDCM, FRCPC	Clinician Investigator (Cancer Research)	Blood cancer	Biomarkers, Clinical research, Clinical trials, Translational research
Schlossmacher, Michael MD, DABPN, FRCPC	Program Director and Senior Scientist (Neuroscience)	Aging, Brain and neuromuscular disease, Crohn's, Dementia, Inflammatory bowel syndrome, Dementia, Parkinson's	Basic research, Biomarkers, Cohort studies, Disease models, Drug development, Genetics, Lipidomics, Molecular and cellular biology, Proteomics, Risk assessment, Transgenic/knockout models, Translational research
Scott, Fraser PhD	Senior Scientist Emeritus (Inflammation and Chronic Disease)	Autoimmune disease, Gastrointestinal disease	Basic research, Biomarkers, Disease models, Molecular and cellular biology, Translational research
Shaw, Joseph MD MSc FRCPC DRCPSC	Associate Scientist (Inflammation and Chronic Disease)	Cancer, Thrombosis / thromboembolism	Biomarkers, Clinical research, Epidemiology, Peri-operative medicine, Pharmacology
Thornhill, Rebecca PhD	Clinician Investigator (Methodological and Implementation Research)	Cancer, Heart disease, Stroke, Vascular, heart and metabolic disease	Artificial intelligence and data science, Biomarkers, Biostatistics, Imaging, Patient safety
Trudel, Guy MD	Senior Scientist (Inflammation and Chronic Disease)	Anemia, Bone and joint degeneration, Musculoskeletal conditions	Basic research, Biomarkers, Molecular and cellular biology, Regenerative medicine, Rehabilitation
Vanderhyden, Barbara PhD	Senior Scientist (Cancer Research)	Cancer, Infertility, Ovarian cancer, Women's health	Basic research, Bioinformatics, Biomarkers, Cancer biotherapeutics, Disease models, Drug development, Epigenetics, Gene expression, Genomics, Immunotherapy, Model organisms, Molecular and cellular biology, Oncolytic viruses, Stem cells, Transgenic/knockout models, Translational research, Viral therapy
Walker, Lisa PhD, C.Psych	Clinician Investigator (Neuroscience)	Anxiety, Autoimmune disease, Autoimmune diseases of the nervous system, Brain and neuromuscular disease, Dementia, Depression, Mental health, Multiple sclerosis	Behaviour, Biomarkers, Clinical research, Exercise, Imaging, Psychology, Psychometrics, Rehabilitation, Stem cells, Systematic reviews, Translational research
Wilson, Kumanan MD, MSc, FRCPC	Senior Scientist (Methodological and Implementation Research)	COVID-19, Global health, Infectious disease, Newborn and child health, Population health	Artificial intelligence and data science, Big data, Biomarkers, Clinical research, Digital and mobile health, Epidemiology, Health services research, Health technology, Immunization, Public health, Transfusions, Translational research
Yogendrakumar, Vignan MD, PhD, FRCPC	Associate Scientist (Neuroscience)	Stroke	Biomarkers, Clinical trials, Cluster randomized trials, Cohort studies, Imaging, Pragmatic trials, Translational research
Allen, Matti MD, PhD	Clinician Investigator (Neuroscience)	Aging, Amyotrophic lateral sclerosis, Brain and neuromuscular disease, Genetic myopathy, Muscular dystrophy, Myasthenia gravis, Neuromuscular disease, Spinal muscular atrophy	Biomarkers, Clinical research, Exercise, Neuro-stimulation, Rehabilitation, Systems biology, Translational research