Alzheimer's

The Ottawa Hospital is conducting cutting-edge research to improve our understanding of Alzheimer's disease and develop better treatments. This page includes selected news stories about our research on Alzheimer's disease, links to researchers working in this area and related resources. Learn more below.

Research News


Could a drug that controls appetite also treat schizophrenia and Alzheimer’s? Mouse studies show promise. Could a drug that controls appetite also treat schizophrenia and Alzheimer’s? Mouse studies show promise.
September 8, 2021 - Two recent studies suggest that the drug trodusquemine has the potential to treat symptoms of both schizophrenia and Alzheimer’s disease. This is because the drug targets an enzyme called PTP1B, which plays a role in both diseases
Diabetes drug corrects some symptoms of Alzheimer’s disease in mice Diabetes drug corrects some symptoms of Alzheimer’s disease in mice
June 4, 2020 - A study in mice led by Dr. Jing Wang suggests that the diabetes drug metformin may be able to reverse some of the symptoms of Alzheimer's disease.
New Frontiers in Research Fund supports trailblazing research on autism, Alzheimer’s, Parkinson’s New Frontiers in Research Fund supports trailblazing research on autism, Alzheimer’s, Parkinson’s
June 3, 2020 - Researchers from The Ottawa Hospital are involved in four new projects funded through the Exploration stream of Canada’s New Frontiers in Research Fund. The fund is designed to support high-risk, high-reward and interdisciplinary research.
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Researchers


Name Scientific appointment Diseases, conditions and populations of interest Research and clinical approaches
Chen, Hsiao-Huei
PhD
Senior Scientist
(NS)
Aging, Autism, Dementia, Depression, Heart disease, Maternal and fetal health, Mental health, Tourette's, Alzheimer's, Alzheimer's, Anxiety, Diabetes, Obesity, Schizophrenia, Stroke, Vascular, heart and metabolic disease Disease models, Drug development, Gene expression, Neuro-stimulation, Optogenetics, Transgenic/knockout models, Basic research, Molecular and cellular biology, Translational research
Manuel, Douglas
MD, MSc, FRCPC
Senior Scientist
(MIR)
Aging, Alzheimer's, Cancer, COVID-19, Dementia, Diabetes, Frailty, Global health, Health equity, Health in disadvantaged peoples, Health in older peoples, Immigrant and refugee health, Infectious disease, Obesity, Parkinson's, Population health, Stroke, Vascular cognitive impairment, Vascular, heart and metabolic disease Artificial intelligence and data science, Big data, Bioinformatics, Biostatistics, Digital and mobile health, Epidemiology, Health research methods, Health services research, Prevention, Public health
Rahgozar, Arya
PhD
Scientist
(MIR)
Aging, Alzheimer's, Brain and neuromuscular disease, Dementia, Parkinson's Artificial intelligence and data science, Digital and mobile health
Ramsay, Timothy
PhD
Senior Scientist
(MIR)
Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, Dystonia, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Santos, Marlise
MD (FRCPC), MSc, MPH
Clinician Investigator
(NS)
Alzheimer's, Anxiety, Ataxia, Autoimmune disease, Autoimmune diseases of the nervous system, Blood cancer, Brain and neuromuscular disease, Brain cancer, Cancer, Concussion, Dementia, Depression, Global health, Head and neck cancer, Health equity, Health in disadvantaged peoples, Infectious disease, Intellectual disabilities, Multiple sclerosis, Parkinson's, Population health, Sickle cell anemia, Spinal cord injury, Stroke, Subarachnoid hemorrhage, Thrombosis / thromboembolism, Traumatic brain injury, Traumatic injuries, Vascular cognitive impairment, Vascular, heart and metabolic disease Artificial intelligence and data science, Basic research, Behaviour, Biostatistics, Cancer biotherapeutics, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Epidemiology, Health economics, Health research methods, Health services research, Health technology, Imaging, Patient safety, Pragmatic trials, Prevention, Public health, Qualitative methods, Quality Improvement, Shared decision making, Surgery, Surveys, Systematic reviews
Thake, Miriam
MD
Clinician Investigator
(ICD)
Aging, Alzheimer's, Health in older peoples, Vascular cognitive impairment
Wang, Jing
Ph.D.
Senior Scientist
(RM)
Alzheimer's, Multiple sclerosis, Stroke Cell therapy, Disease models, Epigenetics, Imaging, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models


Related Resources

Neuroscience Program at the Ottawa Hospital Research Institute

Search for clinical trials at The Ottawa Hospital related to this disease or condition.





Publications

The following research publications are pulled from PubMed using the search terms "Alzheimer's" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases.
2024-07-04

Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19.
2024-05-03

Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study.
2024-03-16

Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative.
2023-12-18

Promising use of metformin in treating neurological disorders: biomarker-guided therapies.
2023-10-20

A Markov constraint to uniquely identify elementary flux mode weights in unimolecular metabolic networks.
2023-10-08

Rare neurovascular genetic and imaging markers across neurodegenerative diseases.
2023-06-05

Men Are at Higher Risk of Screening Positive for Vascular Cognitive Impairment Compared to Women after Stroke and Transient Ischemic Attack.
2023-05-22

Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases.
2023-03-28

Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer's disease.
2023-02-22

View more on PubMed