Ottawa Hospital Research Institute

Research News

	Could a drug that controls appetite also treat schizophrenia and Alzheimer’s? Mouse studies show promise. September 8, 2021 - Two recent studies suggest that the drug trodusquemine has the potential to treat symptoms of both schizophrenia and Alzheimer’s disease. This is because the drug targets an enzyme called PTP1B, which plays a role in both diseases
	Diabetes drug corrects some symptoms of Alzheimer’s disease in mice June 4, 2020 - A study in mice led by Dr. Jing Wang suggests that the diabetes drug metformin may be able to reverse some of the symptoms of Alzheimer's disease.
	New Frontiers in Research Fund supports trailblazing research on autism, Alzheimer’s, Parkinson’s June 3, 2020 - Researchers from The Ottawa Hospital are involved in four new projects funded through the Exploration stream of Canada’s New Frontiers in Research Fund. The fund is designed to support high-risk, high-reward and interdisciplinary research.
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	Study in mice reveals a new target to treat Alzheimer’s disease January 23, 2020 - A new study has found that PTP1B, an enzyme that counteracts insulin and plays an important role in obesity and diabetes, is also a target for treating Alzheimer’s disease. Blocking PTP1B in mouse models of Alzheimer’s restored their spatial memory t
	Ottawa researcher plays key role in $53-million Alzheimer’s research project September 24, 2019 - Dr. Monica Taljaard is playing a major role in a $53-million project funded by the U.S. National Institute of Aging to improve health care and quality of life for people living with Alzheimer’s disease, as well as for their caregivers.
	Brain Health Awareness Week: October 15-19 October 10, 2018 - Researchers, clinicians, patients and members of the general public are invited to take part in Brain Health Awareness Week from October 5-19, hosted by the University of Ottawa Brain and Mind Research Institute, in collaboration with The Ottawa Hosp
	Chaos in the nucleus: research on eye cells could provide insight into degenerative diseases August 22, 2018 - The nucleus of a cell is usually a highly organized structure, with more than a metre of DNA packaged very carefully into a tiny volume. A number of degenerative diseases, including Alzheimer’s, SCA7 and progeria are associated with a breakdown in n
	Award-winning scientist challenges medical dogma in quest to prevent, treat neurodegenerative disease October 25, 2017 - Dr. Michael Schlossmacher grew up in Austria, trained at Harvard and now leads The Ottawa Hospital’s neuroscience research program. His research helped establish a key concept in Alzheimer’s disease and led to a clinical trial of an experimental ther
	$530,000 grant to find Canadians’ most important risk factors for dementia March 30, 2016 - Drs. Doug Manuel and Peter Tanuseputro have been awarded a $530,000 grant from the Canadian Institutes of Health Research (CIHR) to build models that will predict dementia incidence and the future burden of the disease on the Canadian population.

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Chen, Hsiao-Huei PhD	Senior Scientist (NS)	Aging, Autism, Dementia, Depression, Heart disease, Maternal and fetal health, Mental health, Tourette's, Alzheimer's, Alzheimer's, Anxiety, Diabetes, Obesity, Schizophrenia, Stroke, Vascular, heart and metabolic disease	Disease models, Drug development, Gene expression, Neuro-stimulation, Optogenetics, Transgenic/knockout models, Basic research, Molecular and cellular biology, Translational research
Manuel, Douglas MD, MSc, FRCPC	Senior Scientist (MIR)	Aging, Alzheimer's, Cancer, COVID-19, Dementia, Diabetes, Frailty, Global health, Health equity, Health in disadvantaged peoples, Health in older peoples, Immigrant and refugee health, Infectious disease, Obesity, Parkinson's, Population health, Stroke, Vascular cognitive impairment, Vascular, heart and metabolic disease	Artificial intelligence and data science, Big data, Bioinformatics, Biostatistics, Digital and mobile health, Epidemiology, Health research methods, Health services research, Prevention, Public health
Rahgozar, Arya PhD	Scientist (MIR)	Aging, Alzheimer's, Brain and neuromuscular disease, Dementia, Parkinson's	Artificial intelligence and data science, Digital and mobile health
Ramsay, Timothy PhD	Senior Scientist (MIR)	Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury	Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Santos, Marlise MD (FRCPC), MSc, MPH	Clinician Investigator (NS)	Alzheimer's, Anxiety, Ataxia, Autoimmune disease, Autoimmune diseases of the nervous system, Blood cancer, Brain and neuromuscular disease, Brain cancer, Cancer, Concussion, Dementia, Depression, Global health, Head and neck cancer, Health equity, Health in disadvantaged peoples, Infectious disease, Intellectual disabilities, Multiple sclerosis, Parkinson's, Population health, Sickle cell anemia, Spinal cord injury, Stroke, Subarachnoid hemorrhage, Thrombosis / thromboembolism, Traumatic brain injury, Traumatic injuries, Vascular cognitive impairment, Vascular, heart and metabolic disease	Artificial intelligence and data science, Basic research, Behaviour, Biostatistics, Cancer biotherapeutics, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Epidemiology, Health economics, Health research methods, Health services research, Health technology, Imaging, Patient safety, Pragmatic trials, Prevention, Public health, Qualitative methods, Quality Improvement, Shared decision making, Surgery, Surveys, Systematic reviews
Thake, Miriam MD	Clinician Investigator (ICD)	Aging, Alzheimer's, Health in older peoples, Vascular cognitive impairment
Wang, Jing Ph.D.	Senior Scientist (RM)	Alzheimer's, Multiple sclerosis, Stroke	Cell therapy, Disease models, Epigenetics, Imaging, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models

Related Resources

Neuroscience Program at the Ottawa Hospital Research Institute

Search for clinical trials at The Ottawa Hospital related to this disease or condition.

Publications

The following research publications are pulled from PubMed using the search terms "Alzheimer's" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

Estimates of intra-cluster correlation coefficients from 2018 USA Medicare data to inform the design of cluster randomized trials in Alzheimer's and related dementias.
2024-10-31

Beta-Amyloid Related Neurodegenerative and Neurovascular Diseases: Potential Implications for Transfusion Medicine.
2024-10-17

Roncoroni Re-Visited: The Neuronal Intranuclear Rodlet Comes of Age.
2024-08-13

Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases.
2024-07-04

Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19.
2024-05-03

Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study.
2024-03-16

Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative.
2023-12-18

Promising use of metformin in treating neurological disorders: biomarker-guided therapies.
2023-10-20

A Markov constraint to uniquely identify elementary flux mode weights in unimolecular metabolic networks.
2023-10-08

Rare neurovascular genetic and imaging markers across neurodegenerative diseases.
2023-06-05

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