Ottawa Hospital Research Institute

Research News

	3D gel helps researchers find potential drugs for lung cancer, other diseases March 15, 2019 - Researchers in Ottawa and Toronto have created a spongy 3D gel that mimics lung tissue, allowing them to quickly screen hundreds of potential drugs for lung cancer and other diseases.
	Discovery points to innovative new way to treat Duchenne muscular dystrophy January 31, 2019 - Researchers at The Ottawa Hospital and the University of Ottawa have discovered a new way to treat the loss of muscle function caused by Duchenne muscular dystrophy in animal models of the disease. As reported in Cell Stem Cell, the team restored mus
	Could leaky blood vessels be a target for treating migraines? Study opens up promising new area of research August 30, 2018 - Migraine headaches are often accompanied by electrical waves that slowly move across the brain, causing flashes of light and other visual disturbances. Referred to as “migraine aura”, this phenomenon also affects the brain’s blood vessels, allowing
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	Exploiting the Achilles’ heel of a severe form of childhood leukemia March 19, 2018 - Drs. Marjorie Brand and Jean-François Couture were awarded $588,000 from the Canadian Institutes of Health Research to investigate a new treatment approach for one of the most aggressive forms of childhood leukemia. The current treatment for T-cell
	Pre-treated cells boost blood vessel repair November 29, 2017 - Endothelial colony-forming cells (ECFCs) are stem-like cells found in umbilical cord blood that help repair damaged blood vessels. They may hold promise for the treatment of stroke, heart attack and blocked leg arteries. However, their rate of bloo
	How to trick your heart into thinking you exercise: cardiotrophin improves heart health and repairs damage in lab models August 4, 2017 - Researchers have discovered that a protein called cardiotrophin 1 (CT1) can trick the heart into growing in a healthy way and pumping more blood, just as it does in response to exercise and pregnancy. They show that this good kind of heart growth i

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Addison, Christina PhD	Senior Scientist (CR)	Bone and joint degeneration, Cancer, Lung cancer, Lung disease, Pancreatic cancer, Prostate cancer, Breast cancer	Basic research, Clinical research, Cohort studies, Disease models, Drug development, Genetics, Imaging, Model organisms, Translational research, Molecular and cellular biology
Chen, Hsiao-Huei PhD	Senior Scientist (NS)	Aging, Autism, Dementia, Depression, Heart disease, Maternal and fetal health, Mental health, Tourette's, Alzheimer's, Alzheimer's, Anxiety, Diabetes, Obesity, Schizophrenia, Stroke, Vascular, heart and metabolic disease	Disease models, Drug development, Gene expression, Neuro-stimulation, Optogenetics, Transgenic/knockout models, Basic research, Molecular and cellular biology, Translational research
Cook, David PhD	Scientist (CR)	Cancer, Ovarian cancer	Artificial intelligence and data science, Basic research, Big data, Bioinformatics, Biomarkers, Cancer biotherapeutics, Cancer immunotherapy, Cell therapy, Drug development, Epigenetics, Gene expression, Genomics, Imaging, Immunotherapy, Molecular and cellular biology, RNA sequencing, Systems biology, Translational research
Diallo, Jean-Simon PhD	Senior Scientist (CR)	Cancer, COVID-19, Infectious disease	Artificial intelligence and data science, Basic research, Cancer biotherapeutics, Cancer immunotherapy, Drug development, Gene therapy, Immunization, Immunotherapy, Molecular and cellular biology, Oncolytic viruses, Translational research, Viral therapy
Ito, Caryn PhD	Senior Investigator (RM)	Blood cancer, Cancer	Basic research, Bioinformatics, Biomarkers, Drug development, Epigenetics, Molecular and cellular biology, Proteomics, Regenerative medicine, Stem cells, Systems biology, Translational research
Kothary, Rashmi Ph.D.	Senior Scientist (RM)	Neuromuscular disease, Amyotrophic lateral sclerosis, Multiple sclerosis, Muscular dystrophy, Spinal muscular atrophy	Basic research, Disease models, Drug development, Epigenetics, Epigenetics, Gene therapy, Genetics, Imaging, Lipidomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Transgenic/knockout models, Translational research
Liu, Johné PhD	Senior Scientist (ICD)	Aging, Cancer, Infertility, Maternal and fetal health, Pregnancy, Women's health	Basic research, Clinical research, Clinical trials, Disease models, Drug development, Translational research
Megeney, Lynn PhD	Senior Scientist (RM)	Heart disease, Muscular dystrophy	Stem cells, Disease models, Proteomics, Drug development
Ngsee, John Ph.D.	Affiliate Investigator (NS)	Amyotrophic lateral sclerosis, Dementia, Parkinson's	Cell therapy, Drug development, Model organisms, Molecular and cellular biology
Quizi, Jennifer PhD	Investigator (CR)	Cancer, Infectious disease	Cancer biotherapeutics, Cancer immunotherapy, Cell therapy, Drug development, Gene therapy, Immunization, Immunotherapy, Molecular and cellular biology, Oncolytic viruses, Translational research, Viral therapy
Ramsay, Timothy PhD	Senior Scientist (MIR)	Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury	Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Sabourin, Luc PhD	Senior Scientist (CR)	Breast cancer, Muscular dystrophy, Skin cancer	Basic research, Disease models, Drug development, Gene expression, Genetics, Molecular and cellular biology, Proteomics, Stem cells, Transgenic/knockout models
Schlossmacher, Michael MD, DABPN, FRCPC	Program Director and Senior Scientist (NS)	Aging, Brain and neuromuscular disease, Crohn's, Dementia, Inflammatory bowel syndrome, Dementia, Parkinson's	Basic research, Biomarkers, Cohort studies, Disease models, Drug development, Genetics, Lipidomics, Molecular and cellular biology, Proteomics, Risk assessment, Transgenic/knockout models, Translational research
Tanphaichitr, Nongnuj PhD	Senior Scientist Emeritus (ICD)	HIV, Infectious disease, Infertility, Men's health, Sexually transmitted infections, Women's health	Basic research, Contraceptive development, Drug development, Imaging, Lipidomics, Molecular and cellular biology, Proteomics
Tiberi, Mario PhD	Senior Scientist (NS)	Parkinson's, Schizophrenia, Stroke	Basic research, Drug development, Molecular and cellular biology, Proteomics, Translational research
Vanderhyden, Barbara PhD	Senior Scientist (CR)	Cancer, Infertility, Ovarian cancer, Women's health	Basic research, Bioinformatics, Biomarkers, Cancer biotherapeutics, Disease models, Drug development, Epigenetics, Gene expression, Genomics, Immunotherapy, Model organisms, Molecular and cellular biology, Oncolytic viruses, Stem cells, Transgenic/knockout models, Translational research, Viral therapy