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Researchers at The Ottawa Hospital awarded 17 CIHR grants worth $7.5 million

Researchers at The Ottawa Hospital are playing a lead role in 17 new projects funded by the Canadian Institutes of Health Research (CIHR).

These projects will advance science and improve health in areas such as blood cancer, blood clots, palliative care, pregnancy, hypertension, prehabilitation, stem cells, Parkinson's, spinal muscular atrophy, stroke, cannabis and fainting.

"Research projects such as these will help us provide the best care possible for our patients and community, while advancing science and improving health on a global scale," said Dr. Duncan Stewart, Executive Vice-President of Research at The Ottawa Hospital and professor at the University of Ottawa.

The Ottawa Hospital's success rate in this competition was 23 percent compared to a national average of 19 percent. Over the last three years The Ottawa Hospital held an average rank of #3 among hospitals for CIHR funding.

The new grants include:

Understanding the mechanism of TLX1-induced T-cell acute lymphoblastic leukemia - $937,125

Primary thromboprophylaxis with rivaroxaban in patients with malignancy and central venous catheters: TRIM-Line - $1,383,745

  • Principal Investigators: Carrier, Marc; Ikesaka, Rick T
  • Co-investigators: Le Gal, Grégoire; Mallick, Ranjeeta; Siegal, Deborah M; Tagalakis, Vicky; Shivakumar, Sudeep P; Delluc, Aurelien; Wang, Tzu-Fei; Wells, Philip S; Lazo-Langner, Alejandro; Wu, Cynthia M

Use of an automated prospective clinical surveillance tool to drive screening for unmet palliative needs among patients in the final year of life - $719,101

  • Principal Investigators: Downar, James; Graves, Elan; Kutty, Sudha; Wegier, Pete
  • Co-investigators: Munene, Peter; Murphy, Rebekah J; Tanuseputro, Peter; Lapenskie, Julie; Caraiscos, Valerie B; Ailon, Jonathan; Rowan, Declan; Mersmann, Sabine; Barwick, Melanie A; Gratton, Valerie; Halligan, Rachael; Gupta, Melini; Webber, Colleen; Chasen, Martin R; Cargill, Darren C; Kennette, Wendy A ; Lawlor, Peter G; Isenberg, Sarina R; Kobewka, Daniel M; Bhimji, Khadija; Buchman, Stephen (Sandy) H; Herx, Leonie; Jamieson, Trevor

Connection to Perinatal Care for the Management of Maternal Non-Communicable Diseases: The CONNECT Project - $100,000

  • Principal Investigators: El-Chaar, Darine; Fell, Deshayne B
  • Co-investigators: Guo, Yanfang; Manuel, Douglas G; Presseau, Justin; Dayan, Natalie; Muldoon, Katherine A; Walker, Mark C; Edwards, Wesley J; Wise, Lauren; Hawken, Steven; Wen, Shi Wu; Corsi, Daniel J; Keely, Erin J; Pham-Huy, Anne; D'Souza, Rohan D

Characterizing Cardiovascular Outcomes in Subclinical Primary Aldosteronism - $443,701

  • Principal Investigators: Hundemer, Gregory; Goupil, Remi Madore, François Agharazii, Mohsen
  • Co-investigators: Crean, Andrew M; Shaw, Julie; Ramsay, Timothy O; Leung, Alexander; Kline, Gregory

An umbrella review of prehabilitation interventions in surgery to inform policy and practice - $103,275

  • Principal Investigators: McIsaac, Daniel I; Gill, Marlyn; Boland, Laura S; Hutton, Brian E 
  • Co-investigators: Gillis, Chelsia A ; Aucoin, Sylvie D ; Fiore Jr, Julio F; Carli, Francesco Eskander, Antoine ; Fergusson, Dean A ; Forster, Alan J ; McCartney, Colin J ; Moloo, Husein ; Grudzinski, Alexa L ; Khadaroo, Rachel ; Lalu, Manoj M ; Martel, Guillaume ; Nantel, Julie ; Scheede-Bergdahl, Celena ; Taljaard, Monica ; Wijeysundera, Duminda N ; Poitras, Stéphane

Caspase 3 stimulation of dystrophic muscle stem cell differentiation- $810,900

ICarePD: a feasibility controlled trial to investigate the addition of an Integrated Care Network to usual physician-centered care to address complex care needs in Parkinson disease -$432,225

  • Principal Investigators: Mestre, Tiago 
  • Co-investigators: Liddy, Clare E; Kessler, Dorothy E; Taljaard, Monica; Thavorn, Kednapa; Grimes, David A

Extracellular vesicles as a biomarker and therapeutic for Spinal Muscular Atrophy -$100,000

  • Principal Investigator: Parks, Robin J 
  • Co-investigators: Kothary, Rashmi K; Warman Chardon, Jodi; Vacratsis, Panayiotis

Oxidation of Parkin is Linked to Neuroprotection in Adult Mammalian Brain - $879,750

Feasibility of Advanced Consent for ParticipaTION in Acute Stroke Trials (ACTION) - $100,000

  • Principal Investigator: Shamy, Michel C; Dowlatshahi, Dariush 
  • Co-investigators: Fahed, Robert; Gocan, Sophia; Swartz, Richard; Fedyk, Mark; Perry, Jeffrey J ; Menon, Bijoy K; Hill, Michael D; Brehaut, Jamie C; Poppe, Alexandre Y

Post-Bleed Management of Antithrombotic Therapy after Gastrointestinal Bleeding (PANTHER-GI): A Mixed-Methods Study of Patient Values and Preferences- $179,776

  • Principal Investigator: Siegal, Deborah M 
  • Co-investigators: Holbrook, Anne M; Xenodemetropoulos, Ted; Deal, Kenneth R; Little, Derek H; Douketis, James D; Dionne, Joanna C; Carrier, Marc; Stacey, Dawn; Skeith, Leslie; Forbes, Nauzer; Xie, Feng

Investigating the Impact of Cannabis Retail Policies on Health Harms and Benefits - $382,500

  • Principal Investigators: Tanuseputro, Peter; Perlman, Christopher M; Taljaard, Monica; Pinto, Andrew D
  • Co-investigators: Brown, Catherine R; Hobin, Erin P; Manuel, Douglas G; Myran, Daniel; Wilson, Kumanan

Validation of the Canadian Prehospital Syncope Risk Score - $397,800

  • Principal Investigator: Thiruganasambandamoorthy, Venkatesh 
  • Co-investigators: Buick, Jason; Grunau, Brian E; Drennan, Ian; Yan, Justin; Taljaard, Monica; Cheskes, Sheldon; Vaillancourt, Christian; Leduc, Shannon

PEITHO-3. Reduced-dose thrombolytic treatment for patients with higher-intermediate risk acute pulmonary embolism - $478,125

  • Principal Investigators: Kerstin de Wit, Lana Castellucci, Jeffrey Joseph Perry 
  • Co-investigators: J. Douketis, A. Fox-Robichaud, A. Hirsch, S. Kahn, A. Lazo-Langner, M. Rodger, S. Schulman, S. Shivakumar, L. Skeith, J. Weatherald, F. Xie, J. Yan
  • Note: this grant is administered at Queen's University

Effects of dexmedetomidine in patients with agitated delirium in palliative care: an open-label phase 1/2 proof-of-concept, feasibility, and dose-finding clinical trial - $100,000

  • Principal Investigators: James Downar, Salmaan Kanji, Debi Lascelle, Peter G. Lawlor, Henrique Afonseca Parsons
  • Co-investigators: S. Bush, L. Cohen, R. Doctorow, L. Herx, J. Hughes, M. Iqbal, J. Lapenskie, J. Lau, N. Lelievre, J. Simon, A. Sinnarajah, B. Vanderspank, A. Wolfe, C. Zimmermann
  • Note: this grant is administered at Bruyère Research Institute

Supporting Canadians making emergent health decisions to focus on what matters most to them: establishing, testing, and scaling patient-oriented interventions - $100,000

  • Principal Investigators: Stacey, Dawn; Archambault, Patrick; Beaudet, Nicolas; Ethier, Jean-Francois; Ludwig, Claire
  • Co-investigators: N. Bansback, L. Boland, C. Chabot, J. Curran, A. Côté, P. Després, A. Giguère, A. Gogovor, I. Graham, A. Groulx, L. Juneau, D. Kobewka, M. Laberge, K. Lewis, F. Légaré, R. McLean, M. Nelson, L. Sikora, M. Smith, M. Taljaard, B. Vanderspank
  • Note: this grant is administered at uOttawa

These projects are supported by core research resources at The Ottawa Hospital, such as the Ottawa Methods Centre.

About The Ottawa Hospital 

The Ottawa Hospital is one of Canada's top learning and research hospitals, where excellent care is inspired by research and driven by compassion. As the third-largest employer in Ottawa, our support staff, researchers, nurses, physicians, and volunteers never stop seeking solutions to the most complex health-care challenges. Our multi-campus hospital, affiliated with the University of Ottawa, attracts some of the most influential scientific minds from around the world. Backed by generous support from the community, we are committed to providing the world-class, compassionate care we would want for our loved ones. www.ohri.ca

About the University of Ottawa

The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada's top 10 research universities--our professors and researchers explore new approaches to today's challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca

Media contact

Amelia Buchanan
Senior Communication Specialist
Ottawa Hospital Research Institute
Cell: 613-297-8315
ambuchanan@ohri.ca

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The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation.