Team Leader

Ian Stiell

Ian Stiell

Senior Scientist, Acute Care Research

What We Do


Dr. Stiell's research group is a team of diverse individuals with various backgrounds and skill sets that facilitate practice changing research for both pre-hospital and in-hospital emergency medicine settings. As a part of the Emergency Medicine Research Group led by Dr. Stiell himself, his research projects are conducted within the most active and productive emergency medicine research program in Canada. Dr. Stiell's current research focus has been on developing clinical decision rules and on clinical trials involving acutely ill patients treated by pre-hospital services and emergency departments. Past research includes internationally recognized clinical decision rules, and a focus on pre-hospital care for cardiac arrest and trauma victims. Additionally, as 1 of 3 founding Canadian sites in the Canadian Resuscitation Outcomes Consortium (CanROC), the team will directly participate in CanROC's various future multi-centre, multi-year emergency health services research projects. 

For more information on the talented Emergency Medicine Research Group, please view the group's individual profiles here.
 

Research Activities

Clinical Decision Rules and Scales

The Ottawa Rules App
The Ottawa Rules App is now available for iPhone or Android and currently contains the Canadian C-Spine Rule, The Ottawa Ankle Rules, and the Ottawa Knee Rule. The app provides an easy mobile, on the go reference to the Ottawa Rules for physicians and nurses. 

Canadian C-Spine Rule 
The Canadian C-Spine Rule is a validated set of rules to determine necessary radiography in alert and stable trauma patients with a potential cervical spine injury. Through a series of risk-factor determining questions, the highly sensitive rule provides clinicians a simple and clear tool for considering x-ray. Additionally, the C-Spine rule has been a successful tool to train Registered Nurses to safely remove the C-spine collar on patients and ambulate to less urgent care areas if applicable. The C-Spine Rule is internationally recognized and helps in patient comfort the reduction of unnecessary radiography, which cuts costs as well as emergency department wait times.

Ottawa Ankle Rules 
The Ottawa Ankle Rules were derived and validated for alert ED patients (>2 years) with a recent blunt trauma to the ankle or mid-foot. Radiography is recommended if the patient meets the criteria for any of the questions listed. The Ankle Rules are internationally recognized and their high sensitivity helps clinicians determine whether the injury is a sprain, or a fracture which requires radiography without jeopardizing patient safety. Emergency department costs and patient flow are improved by using the Ottawa Ankle Rules.

Ottawa Knee Rule 
The Ottawa Knee Rule provides physicians with a simple guideline to aid in radiography decisions for alert patients (>18 years) with recent minor knee trauma. The simple “yes or no” risk criteria provide a valid and highly sensitive scale to determine the need for x-ray without compromising patient satisfaction. The Ottawa Knee Rule can be safely used by physicians in many countries, and reduces the use of imaging and wait times. 

Canadian CT Head Rule 
The Canadian CT Head Rule safely limits use of imaging for patients (>16 years) with minor head injuries ensuring those who do need imaging receive CT in a timely manner. The validated rule consists of 5 high risk factors and 2 medium risk factors to provide physicians with a standardized care of head injury patients in the emergency department. This highly sensitive rule provides improvement in patient management by reducing unnecessary imaging, improving patient flow and reducing costs. 

HEARTRISK6 Heart Failure Risk Score
We have clinically validated and revised the HEARTRISK6 tool which now consists of six simple variables and which estimates the short-term risk of SSOs (Short-term Serious Outcomes) in acute heart failure patients treated in the ED. The Revised HEARTRISK6 will assist physicians in making rational disposition plans in the ED. This should improve and standardize admission practices, diminishing both unnecessary admissions for low-risk patients and unsafe discharge decisions for high-risk patients, ultimately leading to improved safety for patients and more efficient use of precious hospital resources.

Ottawa COPD Risk Scale (OCRS)
We have clinically validated the OCRS tool and are now in the analysis process to refine the tool which estimates the short-term risk of SAEs (Serious Adverse Events) in COPD (Chronic Obstructive Pulmonary Disease) patients treated in the ED. The OCRS will assist physicians in making rational disposition plans in the ED by improving and standardizing admission practices, diminishing both unnecessary admissions for low-risk patients and unsafe discharge decisions for high-risk patients, ultimately leading to improved safety for patients and more efficient use of precious hospital resources. 
 


Current In-Hospital Research Studies

 RAFF 4 Study:  Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department (Stiell) 
Weekend Discharges Study:  A Study to Decrease Emergency Department Crowding by Creating and Implementing Interventions to Increase Weekend Discharges of Admitted Patients (Stiell) 
HEARTRISK6:  Validation of the HEARTRISK6 Risk Scale (Stiell) 

TIA-4 Study:  Revised Clinical Score for High Risk TIA Patients in the ED (Perry) COBRRA-AF Study: Comparison of Bleeding Risk between Rivaroxaban & Apixaban in Patients with Atrial Fibrillation (Perry)   Right Care Right Place: Right Patient, Right Place, Right Time, etc. (Perry)
VALUE Study:  The right care, for the right patient, at the right time, by the right provider: A value-based comparison of the management of ambulatory patients in walk-in clinics, primary care physician practices and EDs (Perry) 
PEITHO-3:  Pulmonary Embolism International Thrombolysis trial: A reduced dose of thrombolytic treatment for patients with intermediate high-risk acute pulmonary embolism: a randomized controlled trial (Perry) FIND-UM Study:  Understanding Delirium Pathophysiology using Urine Metabolomics from Older People with Hip Fractures (Perry)
Vitamin C Study: Impact of Vitamin C on the Reduction of Opioid Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain: A Double-Blind Randomized Control Trial Protocol (Perry) 

Can SCAHn:  Selective Neuroimaging for Head-injured Emergency Patients Who take Anticoagulant Medication (Eagles) 
Frailty:  Frailty Evaluation in the Emergency Department (Eagles) 

HI-DOCC:  High-Dose Cephalexin for Cellulitis (HI-DOCC): A Randomized Controlled Trial (Yadav) EMPET Study: Emergency Medicine Pulmonary Embolism Testing Multicentre Study (Yadav) 
QueBIC: Prospective Multicenter Validation & Refinement of the Quebec Brain Injury Categories for Patients with Complicated Mild Traumatic Brain Injury (Yadav)





 

 




 


 


 

 

Selected Publications

Stiell IG, Sivilotti MLA, Taljaard M, Birnie D, Vadeboncoeur A, Hohl CM, McRae AD, Rowe BH, Brison RJ, Thiruganasambandamoorthy V, Macle L, Borgundvaag B, Morris J, Mercier E, Clement CM, Brinkhurst J, Sheehan C, Brown E, Nemnom, M-J, Wells GA, Perry JJ.  Electrical versus pharma cological cardioversion for emergency department patients with acute atrial fibrillation (RAFF2): a partial factorial randomised trial. The Lancet. 2020 February 01 Vol. 395, No. 10221, p339–349 View abstract

Stiell IG, Perry JJ, Clement CM, Brison RJ, Rowe BH, Aaron SD, McRae AD, Borgundvaag B, Calder LA, Forster AJ, Brinkhurst J, Wells GA. Clinical validation of a risk scale for serious outcomes among patients with chronic obstructive pulmonary disease managed in the emergency department. CMAJ. 2018 Dec 3;190(48):E1406-E1413.  View abstract 
  
Stiell IG, Brown SP, Nichol G, Cheskes S, Vaillancourt C, Callaway CW, Morrison LJ, Christenson J, Aufderheide TP, Davis DP, Free C, Hostler D, Stouffer JA, Idris A, and the ROC Investigators. What is the Optimal Chest Compression Depth during Out-of-Hospital Cardiac Arrest Resuscitation of Adult Patients? Circulation, 2014 Nov 25;130(22):1962-70. View abstract  

Stiell IG, Clement CM, Brison RJ, Rowe BH, Borgundvaag B, Aaron SD, Lang E, Calder LA, Perry JJ, Forster AJ, Wells GA. Clinical Characteristics Associated with Adverse Events in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: Prospective Cohort Study. CMAJ 2014 Apr 1;186(6):E193-204. View abstract 

Stiell IG, Nichol G, Leroux B, Rea TD, Ornato JP, Powell J et al. Resuscitation Outcomes Consortium ROC PRIMED Trial of Early Rhythm Analysis versus Later Analysis in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2011 Sep 1;365(9):787-97. View abstract 

Stiell IG, Clement CM, Grimshaw JM, Brison RJ, Rowe BH, Lee JS, Shaw A, Brehaut J, Holroyd BR, Schull MJ, McKnight D, Eisenhauer MA, Dreyer J, Letovsky E, Rutledge T, MacPhail I, Ross S, Perry JJ, Ip U, Lesiuk H, Bennett C, Wells GA. A Prospective 12-Centre Cluster Randomized Trial to Implement the Canadian CT Head Rule in Emergency Departments. CMAJ.2010;182(14) Oct 1527-1531. View abstract

Stiell IG, Clement CM, O’Connor A, Davies B, Leclair C, Sheehan P, Clavet T, Beland C, MacKenzie T, Wells GA. Multicenter Prospective Validation of the Canadian C-Spine Rule by Emergency Department Triage Nurses. CMAJ 2010;Aug 10;182(11):1173-9. View abstract

Stiell IG, Clement CM, Grimshaw J, Brison R, Rowe BH, Schull MJ, Lee J, Brehaut J, McKnight D, Eisenhauer MA, Dreyer J, Letovsky E, Rutledge T, MacPhail I, Ross S, Perry JJ, Holroyd BR, Ip U, Lesiuk H, Wells GA. Implementation of the Canadian C-Spine Rule: A Prospective 12-Centre Cluster Randomized Trial. British Medical Journal 2009. BMJ. 2009 Oct 29;339:b4146. View abstract        

Stiell IG, Nesbitt LP, Pickett W, Munkley D, Spaite DW, Banek J, Field B, Luinstra-Toohey L, Maloney J, Dreyer J, Lyver M, Campeau T, Wells GA, for the OPALS Study Group. The OPALS Major Trauma Study: impact of advanced life support on survival and morbidity. Can Med Assoc J 2008;178:1141-1152. View abstract