Duane Hickling profile picture

Contact Information

Duane Hickling, M.D.,M.SCI., FRCSC

Ms. Terri van Gulik
613-737-8899 x 72807

ORCID logo https://orcid.org/0000-0002-7282-6763

Duane Hickling

Clinician Investigator, Clinical Epidemiology Program
Ottawa Hospital Research Institute
Greta and John Hansen Chair in Men's Health and Basic Science Research, Division of Urology, Department of Surgery
Ottawa Hospital Research Institute
Assistant Professor, Divison of Urology, Department of Surgery
University of Ottawa

Research Interests

Research Interests:

 1.  Host Defense Mechanisms in Urinary Tract Infection The overall goal of our research is to better understand UTI pathogenesis as it relates to the host.  Specifically, we are interested in studying constitutive and inducible expression of antimicrobial peptides/host defense proteins in the lower urinary tract.   At the present time, our program integrates in vitro, in vivo and clinical approaches to better understand the roles of LL-37 in UTI pathogenesis.   This important work will lay the foundation for future translational projects pertaining to the UTI and catheter biofilm prevention.  

 2. Recurrent Urinary Tract Infections This research program is focused primarily on uncovering those clinical factors that make some individuals prone to recurrent UTI.  By studying patient demographics and select biomarkers we hope to gain a better understanding of susceptibility to UTI in certain at risk populations and in those who are otherwise seemingly healthy.

Brief Biography

Dr. Duane Hickling has recently joined the Ottawa Hospital Research Institute as an Associate Scientist in the Chronic Disease Program. His research focuses on urinary tract infections and understanding how the body defends against these at the molecular level. Dr. Hickling is also a urologist at The Ottawa Hospital and Assistant Professor in the Division of Urology, Department of Surgery, Faculty of Medicine at the University of Ottawa. After obtaining his MD at Western University, he completed his residency training at The Ottawa Hospital/University of Ottawa and then went on to do a three-year combined clinical and research fellowship at New York University. There he trained in female pelvic medicine and reconstructive surgery, receiving a Master’s degree in Clinical Investigation – Translational Research. 

Selected Publications

1.  Predictors of sling revision after mid-urethral sling procedures: a case-control study. Clancy AA, Gauthier I, Ramirez FD, Hickling D, Pascali D. BJOG. 2018 Sep 16. doi: 10.1111/1471-0528.15470. [Epub ahead of print] 

2. A pilot randomized-controlled trial of the urodynamic efficacy of mirabegron for patients with neurogenic lower urinary tract dysfunction. Welk B, Hickling D, McKibbon M, Radomski S, Ethans K. Neurourol Urodyn. 2018 Aug 31. doi: 10.1002/nau.23774. [Epub ahead of print] 

3.  Editorial Comment. Hickling DR. J Urol. 2018 Oct;200(4):813-814. doi: 10.1016/j.juro.2018.03.170. Epub 2018 Jul 9. No abstract available.  

4. Do Urodynamic Findings Other Than Outlet Obstruction Influence the Decision to Perform a Transurethral Resection of Prostate? Welk B, McGarry P, Baverstock R, Carlson K, Hickling D. Urology. 2018 Jul;117:120-125. doi: 10.1016/j.urology.2018.04.010. Epub 2018 Apr 25. 

5. Complications after minimally invasive sacrocolpopexy with and without concomitant incontinence surgery: A National Surgical Quality Improvement Program (NSQIP) database study. Clancy AA, Mallick R, Breau RH, Khalil H, Hickling DR. Neurourol Urodyn. 2018 Sep;37(7):2234-2241. doi: 10.1002/nau.23574. Epub 2018 Apr 10. 

6.  Urinary function following radical cystectomy and orthotopic neobladder urinary reconstruction. Nayak AL, Cagiannos I, Lavallée LT, Morash C, Hickling D, Mallick R, Breau RH. Can Urol Assoc J. 2018 Jun;12(6):181-186. doi: 10.5489/cuaj.4877. Epub 2018 Feb 23. 

7. Thermal Bladder Injury at Laparoscopic Hysterectomy. Clancy AA, Hickling D. J Minim Invasive Gynecol. 2018 May - Jun;25(4):562-564. doi: 10.1016/j.jmig.2017.08.010. Epub 2017 Aug 10. No abstract available.  

8. Patient-targeted websites on overactive bladder: What are our patients reading? Clancy AA, Hickling D, Didomizio L, Sanaee M, Shehata F, Zee R, Khalil H. Neurourol Urodyn. 2018 Feb;37(2):832-841. doi: 10.1002/nau.23359. Epub 2017 Aug 1.