• Determine how risk factors contribute to ovarian cancer initiation and progression
• Single cell analyses and bioinformatics to investigate various aspects of ovarian cancer
• Design, develop and test novel immune therapies for ovarian cancer
• Evaluate the contributions of target genes in ovarian cancer progression and the immune microenvironment
  

For information regarding individual projects, please see the Lab Members section

Cook DP, Galpin KJC, Rodriguez GM, Shakfa N, Wilson-Sanchez J, Echaibi M, Pereira M, Matuszewska K, Haagsma J, Murshed H, Cudmore AO, Macdonald E, Tone A, Shepherd TG, Petrik JP, Koti M, and BC Vanderhyden (2023). Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancer. Commun. Biol. 6: 1152. https://doi.org/10.1038/s42003-023-05529-z.

Landry DA, Yakubovich E, Cook DP, Fasih S, Upham J and Vanderhyden BC (2022). Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. Science Advances 8(35):eabq1475. doi: 10.1126/sciadv.abq1475

Rodriguez GM, Galpin KJC, Cook DP, Yakubovich E, Maranda V, Macdonald E, Wilson-Sanchez J, Thomas AL, Burdette JE, and BC Vanderhyden (2022). The tumor immune profile of murine ovarian cancer models: An essential tool for ovarian cancer immunotherapy research. Cancer Res. Commun. 2: 417-433.

Cook DP and BC Vanderhyden (2022). Transcriptional census of epithelial-mesenchymal plasticity in cancer. Science Advances 8(1):eabi7640. doi: 10.1126/sciadv.abi7640.

Abedini A, Landry DA, Macaulay AD, Vaishnav H, Parbhakar A, Ibrahim D, Salehi R, Maranda V, Macdonald E and BC Vanderhyden (2022). SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility. Biol Reprod. 108(2):279-291. doi: 10.1093/biolre/ioac209.

David S, Plante A, Dallaire F, Tremblay J-P, Sheehy G, Macdonald E, Forrest L, Daneshmand M, Trudel D, Wilson BC, Hopkins L, Murugkar S, Vanderhyden B, and F Leblond (2022). Multispectral label-free Raman spectroscopy can detect ovarian and endometrial cancer with high accuracy. J. Biophotonics 15(2): e202100198. doi.org/10.1002/jbio.202100198.

Carter LE, DP Cook, CW McCloskey, MA Grondin, DA Landry, T Dang, O Collins, LF Gamwell, HA Dempster, BC Vanderhyden (2021). Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium. Communications Biology, 4(1): 527. doi: 10.1038/s42003-021-02045-w.

Landry DA, HT Vaishnav, BC Vanderhyden (2020). The significance of ovarian fibrosis. Oncotarget 11: 4366-4370. doi: 10.18632/oncotarget.27822.

Robineau-Charette P, Grynspan D, Benton SJ, Gaudet J, Cox BJ, Vanderhyden BC, Bainbridge SA (2020). Fibrinogen-like protein 2-associated transcriptional and histopathological features of immunological preeclampsia. Hypertension 76: 910-921.

Abedini A, C Sayed, LE Carter, D Boerboom, BC. Vanderhyden (2020). Non-canonical WNT5a regulates epithelial-to-mesenchymal transition in the mouse ovarian surface epithelium. Sci. Reports 10: 9695.

Cook DP and BC Vanderhyden (2020). Context specificity of the EMT transcriptional response. Nat. Commun. 11: 2142. doi: 10.1038/s41467-020-16066-2.