Christopher Kennedy

Christopher Kennedy

PhD

Senior Scientist, Inflammation and Chronic Disease

Ottawa Hospital Research Institute

Professor, Medicine / Cellular & Molecular Medicine

University of Ottawa

Contact

613-562-5800 x8529

Research Administrative Coordinator: Jennifer Brownrigg | jebrownrigg@ohri.ca | 613-737-8899 x73810

Bio

Christopher Kennedy is a Senior Scientist within the Inflammation and Chronic Disease Program and Kidney Research Centre at the Ottawa Hospital Research Institute and a Full Professor in the Faculty of Medicine / Department of Medicine at the University of Ottawa. He is the Director of Awards & Prizes in the Faculty of Medicine, a position he has held since 2018.

Dr. Kennedy served as Chair and Scientific Officer of the CIHR Hematology Digestive Diseases and Kidney open operating grant peer review committee as well as Chair of the Advisory Board for the CIHR’s Institute of Nutrition, Metabolism and Diabetes (2017-2021). He chaired the Kidney Foundation of Canada’s Biomedical Research Grants Committee and is a member of the CIHR College of Reviewers.

Dr. Kennedy has provided years of service to the Canadian Council on Animal Care, where he was the representative for the Association of Faculties of Medicine to the Canadian Council of Animal Care, served on the CCAC’s Standards Committee and has over 10 years served on the University of Ottawa’s Animal Care Committee.  Most recently he was Chair of the CCAC Board of Directors, a position he assumed in 2019 after a year as Vice-Chair and is currently a member of the council’s Finance and Strategic Taskforce Planning committees and Ethics subcommittee.

Dr. Kennedy’s research program is a fertile training environment for undergraduates, graduates and postgraduates and is funded by the Canadian Institutes for Health Research (CIHR), the Kidney Foundation of Canada (KFOC), and the Canada Foundation for Innovation.  Employing state-of-the-art animal models, his research seeks to identify how the kidney’s filtration system and vasculature are damaged in diabetes and high blood pressure – the two leading causes of kidney disease in Canada, with the goal of translating his work into novel therapies that would slow down or prevent kidney disease progression.

Research Goals and Interests

Dr. Kennedy’s research program has been funded by the Canadian Institutes for Health Research (CIHR), the Kidney Foundation of Canada (KFOC), and the Canada Foundation for Innovation. He was a CIHR New Investigator Scholar. He has held CIHR operating grants continuously since 2001, seeking to identify factors such as prostaglandins and reactive oxygen species responsible for mediating damage to cells within the kidney’s filtration barrier – known as podocytes. Such injury results in abnormal leakage of protein into the urine. Identifying the specific factors responsible for filtration barrier injury may reveal a novel therapeutic target for the prevention of glomerular diseases. Most recently, his work defined a critical role for a novel NADPH oxidase isoform (Nox5) in diabetic kidney disease. Dr. Kennedy’s KFOC-funded research has shed light on how mutations in the alpha-actinin-4 gene lead to an inherited form of a common kidney disease - focal segmental glomerulosclerosis (FSGS). This research project employs transgenic technology to reproduce this disease state in mice so that its progression can be better studied and novel therapies developed.

The Kennedy Lab focuses on the following areas:

1) Renal prostaglandin biology with emphasis on hemodynamic regulation and glomerular filtration barrier function.

2) Novel mouse models of diabetic kidney disease.

3) NADPH oxidase induced oxidative stress in the kidney and vasculature in disease states (diabetes, hypertension).


News


Publications

Extracellular Vesicle Mitochondrial DNA Reflects Podocyte Mitochondrial Stress and Is Associated with Relapse in Nephrotic Syndrome

2025-07-01 Go to publication

The Proteome of Circulating Large Extracellular Vesicles in Diabetes and Hypertension

2023-03-01 Go to publication

Parkin coregulates glutathione metabolism in adult mammalian brain

2023-01-01

High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury

2023-01-01

Comparative analysis of hypertensive nephrosclerosis in animal models of hypertension and its relevance to human pathology. Glomerulopathy

2022-01-01

Related Research at The Ottawa Hospital