Chen Lab

Identifying Structural Variants and Their Contribution to Cardiovascular Disease Risk: The Long and the Short of It

Revisiting the MMTV Zoonotic Hypothesis to Account for Geographic Variation in Breast Cancer Incidence

Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice

Hyperactivated PTP1B phosphatase in parvalbumin neurons alters anterior cingulate inhibitory circuits and induces autism-like behaviors

Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care

Loss of IRF2BP2 in microglia increases inflammation and functional deficits after focal ischemic brain injury

Interferon regulatory factor 2 binding protein 2: A new player of the innate immune response for stroke recovery

Transcriptomic Signature of Atherosclerosis in the Peripheral Blood: Fact or Fiction?

Making sense of genome-wide association studies: Integrating genetic variation with gene expression to derive functional mechanisms underlying disease risk

IRF2BP2 reduces macrophage inflammation and susceptibility to atherosclerosis