Labs and Groups
Angel HIV Lab
Angel HIV Lab
Team Leader
Jonathan Angel
Senior Scientist, Inflammation and Chronic DiseaseWhat We Do
The Angel Lab conducts basic science and translational research to investigate mechanisms of immune dysfunction during HIV infection, and evaluates the effects of antiretroviral, immune-mediated, or oncolytic virus-based treatments as potential approaches to a cure for HIV. Our research is led by Dr. Jonathan Angel, a clinician scientist and Infectious Diseases specialist, who has played leadership roles on investigator-lead clinical studies, the Canadian HIV Cure Enterprise (CanCURE), and the CIHR Pan-Canadian Network for HIV and STBBI Clinical Trials Research.
Research Activities
Basic science
- Mechanisms of HIV induced immune dysfunction
Translational research
- The impact of antiretrovial and immune-based therapies on immune function in patients with HIV infection
- Investigation of oncolytic viruses as a potential foundation for an HIV cure
Clinical Trials
- Studies on immune based therapies and vaccines in HIV infection
Selected Publications
- N. Ranganath, T.S. Sandstrom, S.C. Burke Schinkel, S.C. Cote, J.B. Angel. “The Oncolytic Virus MG1 Targets and Eliminates Cells Latently Infected with HIV-1: Implications for an HIV Cure.” J Infect Dis. 217(5):721-730, Feb 2018.
- T.S. Sandstrom, N. Ranganath, S.C. Burke Schinkel, S. Salahuddin, O. Meziane, S.C. Coté, C. Costiniuk, M-A. Jenabian, J.B. Angel. “HIV-Infected Macrophages Are Infected and Killed by the Interferon-Sensitive Rhabdovirus MG1.” J. Virol. 95(9):e01953-20, Apr 2021.
- A. Vera-Cruz, N. Tanphaichitr, J.B. Angel. “Antimicrobial Peptide, LL-37, and its Potential as an Anti-HIV Agent.” Clin Invest Med. 44(3):E64-71, Oct 2021.
- B. Molyer, A. Kumar, J.B. Angel. “SMAC Mimetics as Therapeutic Agents in HIV infection.” Front Immunol. 12:780400, Nov 2021.
- S.G. Lee, W. Kiattiburut, S.C. Burke Schinkel, J.B. Angel, N. Tanphaichitr. "Safety of multiple administrations of spermicidal LL-37 antimicrobial peptide into the mouse female reproductive tract." Mol Hum Reprod. 2023 Jun 30;29(7):gaad023, June 2023.
- T.S. Sandstrom, N. Ranganath, S.C. Burke Schinkel, S. Salahuddin, O. Meziane, S.C. Coté, C. Costiniuk, M-A. Jenabian, J.B. Angel. “HIV-Infected Macrophages Are Infected and Killed by the Interferon-Sensitive Rhabdovirus MG1.” J. Virol. 95(9):e01953-20, Apr 2021.
- A. Vera-Cruz, N. Tanphaichitr, J.B. Angel. “Antimicrobial Peptide, LL-37, and its Potential as an Anti-HIV Agent.” Clin Invest Med. 44(3):E64-71, Oct 2021.
- B. Molyer, A. Kumar, J.B. Angel. “SMAC Mimetics as Therapeutic Agents in HIV infection.” Front Immunol. 12:780400, Nov 2021.
- S.G. Lee, W. Kiattiburut, S.C. Burke Schinkel, J.B. Angel, N. Tanphaichitr. "Safety of multiple administrations of spermicidal LL-37 antimicrobial peptide into the mouse female reproductive tract." Mol Hum Reprod. 2023 Jun 30;29(7):gaad023, June 2023.