"Regulating hepatobiliary identity during development and regeneration"

Seminar details

We study two gastrointestinal epithelial tissues with distinct functional characteristics: the intestine and liver. While the intestinal epithelium is rapidly proliferative and replaced regularly by intestinal stem cells (ISCs) throughout adult life, the biliary epithelial cells (BECs) and hepatocytes that make up the liver epithelium are largely quiescent in the absence of injury. While both tissues exhibit remarkable potential for cellular plasticity, repair, and regeneration, the liver accomplishes these processes without a dedicated stem cell pool. We seek to advance mechanistic understanding of the gene regulatory networks required for epithelial development, renewal, and regeneration in functionally distinct tissues. Our long-term goal is to identify gene regulatory relationships that may improve the diagnosis and treatment of developmental disorders, chronic inflammatory disease, and cancer.

Hosted by: Dr. William Stanford

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