Researchers
Dariush Dowlatshahi

Dariush Dowlatshahi

MD PhD FRCP(C)

Senior Scientist, Neuroscience

Ottawa Hospital Research Institute

Professor, Medicine

School of Epidemiology and Public Health

Stroke Neurologist, Medicine

Neurology

Vice Chair of Research, Department of Medicine

University of Ottawa

ORCID, https://orcid.org/0000-0003-1379-3612

Contact

ddowlat@toh.ca

Wendy Lamont Clinical Administrative Assistant 613-761-4709 FAX: 613-761-5360 Patient related inquiries PLEASE NOTE: Prospective graduate students: I offer supervision for MSc and PhD candidates only through the School of Epidemiology and Public Health and the Clinical and Translational Medicine graduate programs. Applications from clinical residents enrolling into the Royal College Clinician Investigator Program are encouraged.

ORCID 0000-0003-1379-3612

Bio

Dr. Dar Dowlatshahi obtained his MD and PhD from McMaster University (Hamilton, Canada), completed a residency in Neurology at the University of Ottawa, Canada, followed by a Stroke Fellowship at the University of Calgary, Canada. He is a Professor of Medicine and Epidemiology at the University of Ottawa, a Senior Scientist at the Ottawa Hospital Research Institute, the Vice Chair Research of the Department of Medicine, and a Stroke Neurologist at the Ottawa Hospital. Dr. Dowlatshahi has over 300 peer-review publications on the topic of stroke and intracerebral hemorrhage and holds a Tier 1 Clinical Research Chair at the University of Ottawa. His research focuses on early hematoma expansion.

Research Goals and Interests

1) Intracerebral Hemorrhage (ICH). I am interested in how acute ICH behaviour relates to clinical symptoms and recovery, and how volume, location & morphology can influence early hematoma expansion, ventricular rupture, and final outcome.

2) Neuroimaging & hyper-acute stroke. I believe multi-modal imaging can optimize acute stroke therapy; findings on CTA and CTP can guide therapeutic decision-making, and expand our current treatment windows.

3) Acute stroke therapy. Our group actively participates in multicentre trials of novel therapies for both ischemic stroke and ICH.

Dr. Dowlatshahi clinical research achievements are as follows:

1) Identifying and measuring ongoing bleeding in acute cerebral hemorrhage. This work led to several publications and a Heart & Stroke Foundation of Canada grant, a 3-year renewal of the grant, and a Heart & Stroke New Investigator award.

2) Defining the minimal clinically important difference for hematoma expansion. This ongoing work has already led to a landmark publication (Neurology 2011) is cited 45 times (Aug 2014) and used for sample size calculations for several clinical trials.

3) Clinician Scientist-Research Chair Award, New Investigator. This inaugural $750K Dept of Medicine award is awarded to the most productive clinician-scientist who is within their first 5-years of appointment for his research in stroke, hemorrhage and anticoagulation.


ONGOING CLINICAL TRIALS & STUDIES that Dr. Dowlatshahi is involved with:

Evaluation of Blood Product Utilization, Healthcare Resource Consumption and Patient Outcomes in New Oral Anticoagulant-Related Hemorrhage

International observational study looking at the Importance of Conventional and Emerging Risk Factors for Stroke in Different Regions of the World and in Different Ethnic Groups

Embrace, A randomized controlled trial of 30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation After a Cerebral Ischemic Event

Multicentre CanPro Registry, Prothrombin Complex Concentrate for anticoagulant-associated intracerebral hemorrhage

Dynamic CTA-ICH study, Predicting intracerebral hemorrhage expansion using the dynamic CTA spot sign

STOP-IT trial, Multicentre RCT of Recombinant FactorVII therapy for CTA spot-positive patient with intracerebral hemorrhage, USA-based RCT

SPOTLIGHT trial, Multicentre RCT of Recombinant FactorVII therapy for CTA spot-positive patient with intracerebral hemorrhage, Canada-based RCT

ICH-ADAPT trial, Multicentre RCT of aggressive blood pressure control with CT-perfusion correlate of perihematoma blood flood in intracerebral hemorrhage

INTERSECT study, Prospective cohort study using post-tPA CT-angiography to determine predictors of re-canalization in acute stroke

PREDICT study, Prospective cohort study to validate the CTA “spot sign” as a predictor of hematoma expansion in intracerebral hemorrhage

News

Publications

Revised intracerebral hemorrhage expansion definitions: Relationship with care limitations

2021-08-01 Go to publication

Ticagrelor vs Clopidogrel in addition to Aspirin in minor ischemic stroke/ transient ischemic attack-Protocol for a systematic review and network meta-analysis.

2021-04-28 Go to publication

The Story of Intracerebral Hemorrhage: From Recalcitrant to Treatable Disease.

2021-04-08 Go to publication

Identifying sex-specific differences in the carotid revascularisation literature: findings from a scoping review.

2021-03-29 Go to publication

Predicting long-term outcomes in acute intracerebral haemorrhage using delayed prognostication scores.

2021-03-23 Go to publication
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