We are investigating the regulation of SLK downstream of migration signaling and characterizing SLK downstream signaling systems. Various approaches such as proteomics, gene knock-outs and transgenics, molecular biology and biochemistry are used to understand SLK signaling.

P. O'Reilly, D. J. Franks, R. Braun and L.A. Sabourin (2005). The Ste20-like kinase SLK is required for cell cycle progression through G2/M. J Biol Chem. 280(51):42383-90.

Z. Chaar, P. O'Reilly, K. Hume and L.A. Sabourin (2006). v-src-Dependent Downregulation of the Ste20-like Kinase SLK by Casein KinaseII. J Biol Chem, 281(38):28193-28199.

S. Wagner, Z.Y. Chaar, K. Roovers, C. J. Storbeck, P. Kolodziej, M. McKay and L.A. Sabourin (2007). FAK/c-src family-dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration. PLoS ONE, 3(4): e1868.

K. Roovers, S. Wagner, M. McKay, P. O'Reilly, V. Lo, J. Northey, J. Chmielecki, W.J. Muller, P. Siegel and L. Sabourin (2009). The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. Oncogene, 28(31):2839-48.

C. Storbeck, K. Hume, S. Wagner, M. McKay, R. Parks, H. Westphal and L.A. Sabourin (2009). The Ldb1 and Ldb2 transcriptional co-factors interact with the Ste20-like kinase SLK and regulate cell migration. Mol Biol Cell, 2009 Oct;20(19):4174-82.